林 慶波
生醫技術平台
姓名 林 慶波
電子郵件 cplin@ym.edu.tw
聯絡電話 +886-2-2826-7338
研究專長 Application of diffusion MRI and functional imaging techniques to interdisciplinary research
簡介

研究簡介

磁振造影技術(MRI),因其非侵入性的優點,使其得以在各相關領域蓬勃發展,本實驗室則是利用更新穎的擴散磁振造影(diffusion MRI)技術,不但將其應用在心理、生理、醫學方面,並著重於技術的發展,以期將傳統MRI及dMRI技術,更廣泛地應用在更多領域。

在心理學領域的研究中,我們將MRI與TMS、MEG、EEG等技術整合,探索不同情境下的人體反應與行為,所對應的大腦功能區為何。MRI不僅可以非侵入性的方式,得取高解析度的解剖影像,並可利用dMRI技術,顯示組織中的微小結構。藉由TMS,不同的大腦功能區因此可加以定位,而透過MEG及EEG對大腦信號傳遞的紀錄,我們更可瞭解大腦在活化後,如何將訊號傳遞到相對應的反應區。結合以上技術,將更有助我們對大腦功能及其結構的深刻瞭解。
在生理結構的研究上,我們採用dMRI技術,來突顯組織的微細結構,如大腦中的神經纖維網路。利用dMRI中的FA及ADC參數,將其與病人的病症作統計分析,這有助於病症的判斷。
在醫學的研究上,dMRI可用於腫瘤病人的術前診斷,並預測術後的回復狀況。同時,透過正常受試者及ADHD病人間的差異比較,不需藉由測定或醫師經驗的診斷,就能輕易發現病人的變化。此外,由dMRI發展出的神經纖維追蹤(Tractography / Fiber Tracking)技術,則有助觀察神經纖維的復原,及幹細胞在大腦中的作用。其他如中風、大腦的創傷與此技術的結合,也在進行中。
在工程研究上,我們發展了神經纖維追蹤(Tractography / Fiber Tracking)技術、擴散譜磁振造影(DSI)技術。DSI,相對於傳統的dMRI技術,又提供了更多組織結構上的資訊。其他如大腦影像的自動化分割(Automatic Segmentation)技術、建立蒙地卡羅模型(Monte-Carlo Simulation Model)在擴散現象的應用、DSI在神經纖維密度的研究、以及dMRI與反應時間的相關研究結合、虛擬實境及其他工具軟體的發展也如火如荼的進行中。相信未來能夠對醫學以及生物領域有更大的幫助。
年度 論文名稱
2010 Chun-Yi Lo, Pei-Ning Wang, Kun-Hsien Chou, Jinhui Wang, Yong He*, Ching-Po Lin*. 2010 “Diffusion tensor tractography reveals abnormal topological organization in structural cortical networks in Alzheimer’s disease” Journal of Neuroscience (In press).
2010 Kun-Hsien Chou, Yawei Cheng, I-Yun Chen, Ching-Po Lin*, Woei-Chyn Chu *. 2010 “Sex-Linked White Matter Microstructure of the Social and the Analytic Brain” NeuroImage (In press).
2010 Kuen-Jer Tsai, Chun-Hung Yang, Yen-Hsin Fang, Kuan-Hung Cho, Wei-Lin Chien, Wei-Ting Wang, Tzu-Wei Wu, Ching-Po Lin, Wen-Mei Fu, Che-Kun James Shen. 2010 “Elevated expression of TDP-43 in the forebrain of mice is sufficient to cause neurological and pathological phenotypes mimicking FTLD-U” Journal of Experimental Medicine (In press).
2010 Wei-Ta Chen, Shuu-Jiun Wang, Jong-Ling Fuh, Ching-Po Lin, Yu-Chieh Ko, Yung-Yang Lin. 2010 “Persistent ictal-like visual cortical excitability in chronic migraine” Pain (In press).
2010 Yawei Cheng, Chen-Yi Chen, Ching-Po Lin, Kun-Hsien Chou, Jean Decety. 2010 “Love hurts: an fMRI study” NeuroImage 51(2): 923-929.
2010 B. B. Biswal, M. Mennes, X. Zuo, S. Gohel, C. Kelly, S. M. Smith, C. F. Beckmann, J. S. Adelstein, R. L. Buckner, S. Colcombe, A. Dogonowski, M. Ernst, D. Fair, M. Hampson, M. J. Hoptman, J. S. Hyde, V. J. Kiviniemi, R. K尒ter, S. Li, C. P. Lin, M. J. Lowe, C. Mackay, D. J. Madden, K. H. Madsen, D. S. Margulies, H. S. Mayberg, K. McMahon, C. S. Monk, S. H. Mostofsky, B. J. Nagel, J. J. Pekar, S. J. Peltier, S. E. Petersen, V. Riedl, S. A. Rombouts, B. Rypma, B. L. Schlaggar, S. S. Seidler, G. J. Siegle, C. Sorg, G. Teng, J. Veijola, A. Villringer, M. Walter, L. Wang, X. Weng, S. Whitfield-Gabrieli, P. Williamson, C. Windischberger, Y. Zang, H. Zhang, F. X. Castellanos, M. P. Milham, 2010 “Towards discovery science of human brain function” Proceedings of the National Academy of Sciences 107:4734-4739.
2010 Chun-Hung Yeh, J.-Donald Tournier, Kuan-Hung Cho, Ching-Po Lin*, Fernando Calamante, Alan Connelly. 2010 “The Effect of Finite Diffusion Gradient Pulse Duration on Fibre Orientation Estimation in Diffusion MRI” NeuroImage 51: 743-751.
2010 Yawei Cheng, Kun-Hsien Chou, I-Yun Chen, Yang-Teng Fan, Jean Decety, Ching-Po Lin*. 2010 “Atypical Development of Frontal Fractional Anisotropy in Adolescents with Autism Spectrum Disorder” NeuroImage, Apr; 50(3): 873-882.
2010 Erick Jorge Canales-Rodríguez+, Ching-Po Lin+, Yasser Iturria-Medina, Chun-Hung Yeh, Kuan-Hung Cho, Lester Melie-Garcia. 2010 “Diffusion Orientation Transform Revisited” NeuroImage, Jan 15; 49(2): 1326-39.
2010 Cheng-Ta Li, Ching-Po Lin*, Kun-Hsien Chou, I-Yun Chen, Jen-Chuen Hsieh, Chia-Liang Wu, Wei-Chen Lin, Tung-Ping Su*. 2010 “Structural and cognitive deficits in remitted and non-remitted recurrent depression: A voxel based morphometric study” NeuroImage, 50: 347–356.
2010 Ke-Hsin Chen, Hsin-Ya Fan, Su-Ping Tsao, Yi-Ping Chao, Ching-Po Lin*. 2010 “Probabilistic Language Pathways Based HARDI Tractography” Chinese Journal of Magnetic Resonance, 27(3):1-8.
2010 Yu-Ming Chuang, Wanyuo Guo, Ching-Po Lin. 2010 “Appraising the Plasticity of the Circle of Willis: A Model of Hemodynamic Modulation in Cerebral Arteriovenous Malformations” European Neurology, 63: 295–301.
2009 Yi-Ping Chao, Kuan-Hung Cho, Chun-Hung Yeh, Kun-Hsien Chou, Jyh-Horng Chen, Ching-Po Lin*. 2009 “Probabilistic topography of human corpus callosum using cytoarchitectural parcellation and HARDI-tractography” Human Brain Mapping, Oct; 30(10): 3172-87.
2009 Kuan-Hung Cho, Chun-Hung Yeh, Jyh-Horng Chen, Ching-Po Lin*. 2009 “Potential in reducing scan times of HARDI by accurate correction of the cross-term in a hemi-spherical encoding scheme” Journal of Magnetic Resonance Imaging, Jun; 29(6): 1386-94.
2009 Wei-Che Lin, Cheng-Hsien Lu, Yu-Chang Lee, Hung-Chen Wang, Chun-Chung Lui, Yu-Fan Cheng, Yi-Ting Shih, Ching-Po Lin*. 2009 “White matter damage in carbon monoxide intoxication assessed in vivo using diffusion tensor MRI” American Journal of Neuroradiology, Jun; 30(6): 1248-55.
2009 Meng-Rui Lee, Yu-Ming Chuang, Wen-Jone Chen, Ching-Po Lin. 2009 “Meticulous blood pressure control is mandatory for symptomatic primitive trigeminal artery” Am J Emerg Med, 27 (5) pp. 634.e5-7.
2009 Wei-Ta Chen, Shuu-Jiun Wang, Jong-Ling Fuh, Ching-Po Lin, Yu-Chieh Ko, Yung-Yang Lin. 2009 “Peri-ictal Normalization of Visual Cortex Excitability in Migraine: an MEG Study” Cephalalgia, 29: 1202-1211.
2009 Xiujuan Geng, Thomas J. Ross, Wang Zhan, Hong Gu, Yi-Ping Chao, Ching-Po Lin, Gary E. Christensen, Norbert Schuff, Yihong Yang. 2009 “Diffusion MRI registration using orientation distribution functions” Inf Process Med Imaging 21: 626-37.
2009 Yu-Ming Chuang, Ching-Po Lin, Ho-Fai Wong, Yeu-Jhy Chang, Chien-Hung Chang, Ting-Yu Chang, Tai-Cheng Wu, Hsiu-Chuan Wu, Tsong-Hai Lee. 2009 “Plasticity of Circle of Willis: A longitudinal Observation of Flow Patterns in the circle of Willis One Week After Stenting for Severe Internal Carotid Artery Stenosis” Cerebrovascular Diseases, Apr 24; 27(6): 572-578.
2009 Yu-Ming Chuang, Chien-Chih Chen, Ching-Po Lin. 2009 “Vertebral artery hypoplasia may contribute to abnormal vestibular evoked myogenic potential” Acta Neurol Taiwan, Jun; 18(2): 113-7.
2009 Ya Mei Bai, Kun-Hsien Chou, Ching-Po Lin*, I-Yun Chen, Cheng-Ta Li, Yang Kai Chun, Tung-Ping Su*. 2009 “White Matter Abnormalities in Schizophrenia Patients with Tardive Dyskinsia: A Diffusion Tensor Image Study” Schizophrenia Research, Apr; 109(1-3): 167-181.
2009 Yawei Cheng, Kun-Hsien Chou, Jean Decety, I-Yun Chen, Daisy Hung, Ovid Jyh-Lang Tzeng, Ching-Po Lin*. 2009 “Sex Differences in the Neuroanatomy of Human Mirror-Neuron System: a Voxel-Based Morphometric Investigation” Neuroscience, Jan; 158(2): 713–720.
2008 Kuan-Hung Cho, Chun-Hung Yeh, Jacques-Donald Tournier, Yi Ping Chao, Jyh-Horng Chen*, Ching-Po Lin*. 2008 “Evaluation of the accuracy and angular resolution of Q-ball imaging” NeuroImage, Aug 1; 42(1): 262-271.
2008 J-Donald Tournier, Chun-Hung Yeh, Fernando Calamante, Kuan-Hung Cho, Alan Connelly, Ching-Po Lin*. 2008 “Resolving crossing fibres using constrained spherical deconvolution: validation using diffusion weighted imaging phantom data” NeuroImage, Aug 15; 42(2): 617-625.
2008 Chun-Hung Yeh, Kuan-Hung Cho, Hsuan-Cheng Lin, Jiun-Jie Wang, Ching-Po Lin*. 2008 “Reduced Encoding Diffusion Spectrum Imaging Implemented with a Bi-Gaussian Model” IEEE Transactions on Medical Imaging, Oct; 27(10): 1415-24.
2008 Yi-Ping Chao, Jyh-Horng Chen, Kuan-Hung Cho, Chun-Hung Yeh, Kun-Hsien Chou, Ching-Po Lin*. 2008 “A Multiple Streamline Approach to High Angular Resolution Diffusion Tractography” Medical Engineering & Physics, Oct; 30(8): 989–996.
2008 Yu-Ming Chuang, Chih-Yang Liu, Po-Jung Pan, Ching-Po Lin*. 2008 “Posterior Communicating Artery Hypoplasia might Contribute to Acute Ischemic Stroke in the Absence of Carotid Artery Occlusion” Journal of Clinical Neuroscience, Dec; 15(12): 1376-1381.
2008 Ching-Po Lin, Wan-Yuo Guo, Kun-Hsien Chou, Ming-Teh Chen, Min-Hsiung Chen, Yu-Shu Yen, Yi-Ping Chao, Donald Ming-Tak Ho. 2008 “Peri-tumoral Fractional Anisotropy Mapping as a Prognosticator and Treatment Guidance of Brain Tumors: A Feasibility Study” Journal of Medical and Biological Engineering, Sep; 28 (3): 139-145.
2008 Yawei Cheng, Po-Lei Lee, Chia-Yen Yang, Ching-Po Lin, Jean Decety. 2008 “Gender Differences in the Mu Rhythm of the Human Mirror Neuron System” PLoS ONE, May 7; 3(5): e2113, 1-7.
2008 Yawei Cheng, Chia-Yen Yang, Ching-Po Lin, Po-Lei Lee, Jean Decety. 2008 “The Perception of Pain in Others Suppresses Somatosensory Oscillations: A Magnetoencephalography Study” NeuroImage, May 1; 40(4): 1833-1840.
2008 Erick J. Canales-Rodríguez, Yasser Alemán-Gómez, Ching-Po Lin, Yasser Iturria-Medina, Pedro A. Valdés-Hernández, Lester Melie-García. 2008 “A Bayesian framework to identify principal intravoxel diffusion profiles based on Diffusion-Weighted MR Imaging” NeuroImage, Aug 15; 42(2): 750-770.
2008 Erick Jorge Canales-Rodríguez, Lester Melie-García, Yasser Iturria-Medina, Eduardo Martínez-Montes, Yasser Alemán-Gómez, Ching-Po Lin. 2008 “Inferring Multiple Maxima in Intravoxel White Matter Fiber Distribution” Magnetic Resonance in Medicine, Sep; 60(3): 616-630.
2008 Jiun-Jie Wang, Yu-Chun Lin, Yau-Yau Wai, Hao-Li Liu, Ching-Po Lin, Ying-Zu Huang. 2008 “Visualization of the coherence of the principal diffusion orientation: an eigenvector-based approach” Magnetic Resonance in Medicine, 59(4): 764-70.
2008 Yu-Ming Chuang, Yuan-Chung Hwang, Ching-Po Lin*, Chih-Yang Liu. 2008 “Toward A Further Elucidation: Role of Vertebral Artery Hypoplasia in Migraine with Aura” European Neurology, 59(3-4): 148-151.
2008 林慶波,大腦神經網路:凡走過必留下痕跡,2008,科學人四月刊
2008 林慶波、江品儀、趙一平,擴散磁振造影之發展與應用,2008,科儀新知四月刊
2007 Yu-Ming Chuang, Chih-Yang Liu, Po-Jung Pan, Ching-Po Lin*. 2007 “Anterior Cerebral Artery A1 Segment Hypoplasia May Contribute to A1 Hypoplasia Syndrome” European Neurology, Jan 19; 57(4): 208-211.
2007 Yawei Cheng, Ching-Po Lin, Ho-Ling Liu, Yuan-Yu Hsu, Kun-Eng Lim, Daisy Hung, Jean Decety. 2007 “Expertise Modulates Pain Perception in Others” Current Biology, Oct 9; 17(19): 1708-1713.
2007 Yawei Cheng, Jean Decety, Ching-Po Lin, Jen-Chuen Hsieh, Daisy Hung, Ovid J.L. Tzeng. 2007 “Sex differences in spinal excitability during observation of bipedal locomotion” Neuroreport, 18(9): 887-890.
2006 Shih-Hwa Chiou, Chung-Lan Kao, Han-Tso Lin, Wen-Ser Tseng, Ren-Shyan Liu, Chen-Fun Chung, Hung-Hai Ku, Ching-Po Lin, Tai-Tong Wong. 2006 “Monitoring the Growth Effect of Xenotransplanted Human Medulloblastoma in Immunocompromised Mice Model Using In Vitro and Ex Vivo Green Fluorescent Protein Imaging” Childs Nervous System, 22: 485-490.
2003 Ching-Po Lin, Van J. Wedeen, Ching Yao, Jyh-Horng Chen, Wen-Yih I. Tseng. 2003. “Validation of Diffusion Spectrum Magnetic Resonance Imaging with Registered Manganese-enhanced Optic Tracts and Phantom” NeuroImage, Jul; 19(3): 482-495.
2001 Ching-Po Lin, Wen-Yih Isaac Tseng, Hui-Cheng Cheng, Jyh-Horng Chen. 2001. “Validation of Diffusion Tensor Magnetic Resonance Axonal Fiber Imaging with Registered Manganese-enhanced Optic Tracts” NeuroImage, Nov; 14(5): 1035-1047.