鄭 菡若
基礎神經研究團隊
姓名 鄭 菡若
電子郵件 hjcheng@ym.edu.tw
聯絡電話 (02)2826-7905
POSITION TITLE/AFFILIATIONS 2013- 陽明交通大學腦科學研究所 專任副教授
2007-2012 陽明大學腦科學研究所 專任助理教授
2002-2007 美國加州大學舊金山分校Gladstone神經退化疾病研究所 博士後研究員
2002 美國康乃爾大學分子生物暨遺傳學系 助教
EDUCATION/TRAINING 2002 美國 康乃爾大學 分子生物暨遺傳學 博士
1996 國立台灣大學 農業化學系 學士
研究專長 Biochemical, cellular, and animal studies of Alzheimer's disease
研究概況 阿茲海默症是造成老年人致認知功能衰退的主因,可惜迄今未見有效的預防及治療方式。本實驗室目前。諸多研究成果顯示,類澱粉乙型蛋白(Aβ)不正常的聚集累積為導致阿茲海默症主因之一。Aβ為類澱粉前驅蛋白(amyloid precursor proteins, APP) 之裂解產物,會聚集成許不同有毒的結構。本實驗室研究主旨,在於理解造成阿茲海默症患者記憶喪失及神經功能退化的原因,以期找出可能用於治療此疾病的新目標。本實驗室目前的研究方向有三個:
1. 利用生化與細胞學的方法,研究在台灣家族中會造成早發性阿茲海默症家族中 ,所發現的APP與PSEN1基因突變,所造成的致病分子機轉。
2. 利用APP基因轉殖鼠,探討不同環境或基因的調控,對神經退化及記憶缺失是否有影響,及評估新的治療或預防認知功能退化策略之有效性和安全性。
3. 與臨床團隊合作,尋找血液中可協助診斷的生物標誌。
年度 論文名稱
2015 Cheng WH, Chen MC, Cheng IH*. Antroquinonol Lowers Brain Amyloid-β Levels and Improves Spatial Learning and Memory in a Transgenic Mouse Model of Alzheimer’s Disease. Scientific Reports 2015 Oct 15;5:15067. doi: 10.1038/srep15067 (Impact factor: 5.578;Rank: 8.93%)
2014 ChenWT, Hsieh YF, Huang YJ, Lin CC, Lin YT, Liu YC, Lien CC and Cheng IH*.. G206D mutation of Presenilin-1 reduces Pen2 interaction, increases Aβ42/Aβ40 ratio and elevates ER Ca2+ accumulation. MOLECULAR NEUROBIOLOGY 2014; accept:. (Impact factor: 5.286;Rank: 15.94%)
2014 Lin YC, Wang JY, Wang KC, Liao JY, Cheng IH (2014) Differential regulation of amyloid precursor protein sorting with pathological mutations results in a distinct effect on amyloid-β production. J Neurochem (accept) (IF :4.244)
2014 Fang YS, Tsai KJ, Chang YJ, Kao P, Woods R, Kuo PH, Wu CC, Liao JY, Chou SC, Lin V, Jin LW, Yuan H, Cheng IH, Tu PH, and Chen YR (2014) Full-Length TDP-43 Forms Toxic Amyloid Oligomers that are Present in Frontotemporal Lobar Dementia-TDP Patients. Nature Communication (Accept)(IF :10.742)
2013 Wu P-Y, Huang Y-Y, Chen C-C, Hsu T-T, Lin Y-C, Weng J-Y, Chien T-C, Cheng IH, Lien C-C (2013) Acid-Sensing Ion Channel-1a Is Not Required for Normal Hippocampal LTP and Spatial Memory. The Journal of Neuroscience 33:1828-1832.
2013 Huang C-W, Wang S-J, Wu S-J, Yang C-C, Huang M-W, Lin C-H, Cheng IH* (2013) Potential Blood Biomarker for Disease Severity in the Taiwanese Population With Alzheimer’s Disease. American Journal of Alzheimer's Disease and Other Dementias 28:75-83z
2012 Chen W-T, Hong C-J, Lin Y-T, Chang W-H, Huang H-T, Liao J-Y, Chang Y-J, Hsieh Y-F, Cheng C-Y, Liu H-C, Chen Y-R, Cheng IH* (2012) Amyloid-Beta (Aβ) D7H Mutation Increases Oligomeric Aβ42 and Alters Properties of Aβ-Zinc/Copper Assemblies. PLoS ONE 7:e35807
2012 Chu Y-F, Chen Y, Brown PH, Lyle BJ, Black RM, Cheng IH, Ou B, Prior RL (2012) Bioactivities of crude caffeine: Antioxidant activity, cyclooxygenase-2 inhibition, and enhanced glucose uptake. Food Chemistry 131:564-568.
2012 Chu Y, Chang W, Black R, Liu J, Sompol P, Chen Y, Wei H, Zhao Q, Cheng IH* (2012) Crude caffeine reduces memory impairment and amyloid β(1-42) levels in an Alzheimer's mouse model. Food Chemistry 135:2095-2102.
2011 Cheng IH*, Lin YC, Hwang E, Huang HT, Chang WH, Liu YL, Chao CY (2011) Collagen VI protects against neuronal apoptosis elicited by ultraviolet irradiation via an Akt/Phosphatidylinositol 3-kinase signaling pathway. Neuroscience 183:178-188.
2011 Chen W-T, Liao Y-H, Yu H-M, Cheng IH, Chen Y-R (2011) Distinct Effects of Zn2+, Cu2+, Fe3+, and Al3+ on Amyloid-β Stability, Oligomerization, and Aggregation. Journal of Biological Chemistry 286:9646-9656
2011 Wu Y-Y, Cheng IH, Lee C-C, Chiu M-J, Lee M-J, Chen T-F, Hsu J-L (2011) Clinical Phenotype of G206D Mutation in the Presenilin 1 Gene in Pathologically Confirmed Familial Alzheimer's Disease. Journal of Alzheimer's Disease 25:145-150.
2010 Hong C-J, Tsai P-J, Cheng C-Y, Chou C-K, Jheng H-F, Chuang Y-C, Yang C-N, Lin Y-T, Hsu C-W, Cheng IH, Chen S-Y, Tsai S-J, Liou Y-J, Tsai Y-S (2010) ENU Mutagenesis Identifies Mice with Morbid Obesity and Severe Hyperinsulinemia Caused by a Novel Mutation in Leptin. PLoS ONE 5:e15333.
2009 Cheng JS, Dubal DB, Kim DH, Legleiter J, Cheng IH, Yu G-Q, Tesseur I, Wyss-Coray T, Bonaldo P, Mucke L (2009) Collagen VI protects neurons against A[beta] toxicity. Nat Neurosci 12:119-121.
2009 Chu Y-F, Brown PH, Lyle BJ, Chen Y, Black RM, Williams CE, Lin Y-C, Hsu C-W, Cheng IH* (2009) Roasted Coffees High in Lipophilic Antioxidants and Chlorogenic Acid Lactones Are More Neuroprotective than Green Coffees. Journal of Agricultural and Food Chemistry 57:9801-9808.
2009 Meilandt WJ, Cisse M, Ho K, Wu T, Esposito LA, Scearce-Levie K, Cheng IH, Yu G-Q, Mucke L (2009) Neprilysin Overexpression Inhibits Plaque Formation But Fails to Reduce Pathogenic Aβ Oligomers and Associated Cognitive Deficits in Human Amyloid Precursor Protein Transgenic Mice. The Journal of Neuroscience 29:1977-1986.
2008 Sanchez-Mejia R, Newman J, Toh S , Yu GQ , Zhou Y , Scearce-Levie K, Cheng IH, Gan L , Palop JJ, Bonventre J, Mucke L (2008) Phospholipase A2 reduction ameliorates cognitive deficits in mouse model of Alzheimer's disease. Nat. Neuroscience 11, 1311 - 1318
2007 Cheng IH, Scearce-Levie K, Palop J, Legleiterl J, Puoivali J, Lesne S, Ashe K, Muchowski P, & Mucke L. (2007) Accelerating Plaque Formation Reduces the Pathogenic Non-Fibrillar Amyloid-β Assembly in Arctic Mutant Alzheimer’s Disease Mouse Models. J. Biol. Chem. 282, 23818-23828
2007 Roberson ED, Scearce-Levie K, Palop JJ, Yan F, Cheng IH, Wu T, Gerstein H, Yu GQ, Mucke L (2007) Reducing endogenous tau ameliorates amyloid-b induced deficits in an Alzheimer’s disease mouse model. Science. 316, 750-754.
2006 Ji Z-S, Mullendorff K, Cheng IH, Miranda RD, Huang Y, & Mahley RW (2006) Reactivity of Apolipoprotein E4 and Amyloid -βPeptide: Lysosomal Stability and Neurodegeneration. J. Biol. Chem. 281:2683-2692
2004 Cheng IH, Palop J, Esposito L, Bien-Ly N, Yan F, & Mucke L. Aggressive Amyloidosis in Mice Expressing Human Amyloid Peptides with the Arctic Mutation. Nature Medicine. 2004 10, 1190-1192.
2004 Sawyer SL, Cheng IH, Chai W,& Tye BK. (2004) Mcm10 and Cdc45 Cooperate in Origin Activation in Saccharomyces cerevisiae. J. Mol. Biol. 2004 340, 195-202.
2002 Cheng IH, Roberts LA, & Tye BK. Mcm3 Is Polyubiquitinated during Mitosis before Establishment of the Pre-replication Complex. J. Biol. Chem. 2002 277: 41706-41714.
2002 Lei M, Cheng, IH, Roberts, LA, McAlear, MA, & Tye BK. Two mcm3 Mutants Affect Different Steps in the Initiation of DNA Replication. J. Biol. Chem. 2002 277: 30824-30831.