林 庆波
生医技术平台
姓名 林 庆波
电子邮件 cplin@ym.edu.tw
联络电话 +886-2-2826-7338
研究专长 Application of diffusion MRI and functional imaging techniques to interdisciplinary research
简介

研究简介

磁振造影技术(MRI),因其非侵入性的优点,使其得以在各相关领域蓬勃发展,本实验室则是利用更新颖的扩散磁振造影(diffusion MRI)技术,不但将其应用在心理、生理、医学方面,并着重于技术的发展,以期将传统MRI及dMRI技术,更广泛地应用在更多领域。

在心理学领域的研究中,我们将MRI与TMS、MEG、EEG等技术整合,探索不同情境下的人体反应与行为,所对应的大脑功能区为何。MRI不仅可以非侵入性的方式,得取高分辨率的解剖影像,并可利用dMRI技术,显示组织中的微小结构。借由TMS,不同的大脑功能区因此可加以定位,而透过MEG及EEG对大脑信号传递的纪录,我们更可了解大脑在活化后,如何将讯号传递到相对应的反应区。结合以上技术,将更有助我们对大脑功能及其结构的深刻了解。
在生理结构的研究上,我们采用dMRI技术,来突显组织的微细结构,如大脑中的神经纤维网络。利用dMRI中的FA及ADC参数,将其与病人的病症作统计分析,这有助于病症的判断。
在医学的研究上,dMRI可用于肿瘤病人的术前诊断,并预测术后的回复状况。同时,透过正常受试者及ADHD病人间的差异比较,不需借由测定或医师经验的诊断,就能轻易发现病人的变化。此外,由dMRI发展出的神经纤维追踪(Tractography / Fiber Tracking)技术,则有助观察神经纤维的复原,及干细胞在大脑中的作用。其他如中风、大脑的创伤与此技术的结合,也在进行中。
在工程研究上,我们发展了神经纤维追踪(Tractography / Fiber Tracking)技术、扩散谱磁振造影(DSI)技术。DSI,相对于传统的dMRI技术,又提供了更多组织结构上的资讯。其他如大脑影像的自动化分割(Automatic Segmentation)技术、建立蒙地卡罗模型(Monte-Carlo Simulation Model)在扩散现象的应用、DSI在神经纤维密度的研究、以及dMRI与反应时间的相关研究结合、虚拟实境及其他工具软件的发展也如火如荼的进行中。相信未来能够对医学以及生物领域有更大的帮助。
年度 论文名称
2010 Chun-Yi Lo, Pei-Ning Wang, Kun-Hsien Chou, Jinhui Wang, Yong He*, Ching-Po Lin*. 2010 “Diffusion tensor tractography reveals abnormal topological organization in structural cortical networks in Alzheimer’s disease” Journal of Neuroscience (In press).
2010 Kun-Hsien Chou, Yawei Cheng, I-Yun Chen, Ching-Po Lin*, Woei-Chyn Chu *. 2010 “Sex-Linked White Matter Microstructure of the Social and the Analytic Brain” NeuroImage (In press).
2010 Kuen-Jer Tsai, Chun-Hung Yang, Yen-Hsin Fang, Kuan-Hung Cho, Wei-Lin Chien, Wei-Ting Wang, Tzu-Wei Wu, Ching-Po Lin, Wen-Mei Fu, Che-Kun James Shen. 2010 “Elevated expression of TDP-43 in the forebrain of mice is sufficient to cause neurological and pathological phenotypes mimicking FTLD-U” Journal of Experimental Medicine (In press).
2010 Wei-Ta Chen, Shuu-Jiun Wang, Jong-Ling Fuh, Ching-Po Lin, Yu-Chieh Ko, Yung-Yang Lin. 2010 “Persistent ictal-like visual cortical excitability in chronic migraine” Pain (In press).
2010 Yawei Cheng, Chen-Yi Chen, Ching-Po Lin, Kun-Hsien Chou, Jean Decety. 2010 “Love hurts: an fMRI study” NeuroImage 51(2): 923-929.
2010 B. B. Biswal, M. Mennes, X. Zuo, S. Gohel, C. Kelly, S. M. Smith, C. F. Beckmann, J. S. Adelstein, R. L. Buckner, S. Colcombe, A. Dogonowski, M. Ernst, D. Fair, M. Hampson, M. J. Hoptman, J. S. Hyde, V. J. Kiviniemi, R. K尒ter, S. Li, C. P. Lin, M. J. Lowe, C. Mackay, D. J. Madden, K. H. Madsen, D. S. Margulies, H. S. Mayberg, K. McMahon, C. S. Monk, S. H. Mostofsky, B. J. Nagel, J. J. Pekar, S. J. Peltier, S. E. Petersen, V. Riedl, S. A. Rombouts, B. Rypma, B. L. Schlaggar, S. S. Seidler, G. J. Siegle, C. Sorg, G. Teng, J. Veijola, A. Villringer, M. Walter, L. Wang, X. Weng, S. Whitfield-Gabrieli, P. Williamson, C. Windischberger, Y. Zang, H. Zhang, F. X. Castellanos, M. P. Milham, 2010 “Towards discovery science of human brain function” Proceedings of the National Academy of Sciences 107:4734-4739.
2010 Chun-Hung Yeh, J.-Donald Tournier, Kuan-Hung Cho, Ching-Po Lin*, Fernando Calamante, Alan Connelly. 2010 “The Effect of Finite Diffusion Gradient Pulse Duration on Fibre Orientation Estimation in Diffusion MRI” NeuroImage 51: 743-751.
2010 Yawei Cheng, Kun-Hsien Chou, I-Yun Chen, Yang-Teng Fan, Jean Decety, Ching-Po Lin*. 2010 “Atypical Development of Frontal Fractional Anisotropy in Adolescents with Autism Spectrum Disorder” NeuroImage, Apr; 50(3): 873-882.
2010 Erick Jorge Canales-Rodríguez+, Ching-Po Lin+, Yasser Iturria-Medina, Chun-Hung Yeh, Kuan-Hung Cho, Lester Melie-Garcia. 2010 “Diffusion Orientation Transform Revisited” NeuroImage, Jan 15; 49(2): 1326-39.
2010 Cheng-Ta Li, Ching-Po Lin*, Kun-Hsien Chou, I-Yun Chen, Jen-Chuen Hsieh, Chia-Liang Wu, Wei-Chen Lin, Tung-Ping Su*. 2010 “Structural and cognitive deficits in remitted and non-remitted recurrent depression: A voxel based morphometric study” NeuroImage, 50: 347–356.
2010 Ke-Hsin Chen, Hsin-Ya Fan, Su-Ping Tsao, Yi-Ping Chao, Ching-Po Lin*. 2010 “Probabilistic Language Pathways Based HARDI Tractography” Chinese Journal of Magnetic Resonance, 27(3):1-8.
2010 Yu-Ming Chuang, Wanyuo Guo, Ching-Po Lin. 2010 “Appraising the Plasticity of the Circle of Willis: A Model of Hemodynamic Modulation in Cerebral Arteriovenous Malformations” European Neurology, 63: 295–301.
2009 Yi-Ping Chao, Kuan-Hung Cho, Chun-Hung Yeh, Kun-Hsien Chou, Jyh-Horng Chen, Ching-Po Lin*. 2009 “Probabilistic topography of human corpus callosum using cytoarchitectural parcellation and HARDI-tractography” Human Brain Mapping, Oct; 30(10): 3172-87.
2009 Kuan-Hung Cho, Chun-Hung Yeh, Jyh-Horng Chen, Ching-Po Lin*. 2009 “Potential in reducing scan times of HARDI by accurate correction of the cross-term in a hemi-spherical encoding scheme” Journal of Magnetic Resonance Imaging, Jun; 29(6): 1386-94.
2009 Wei-Che Lin, Cheng-Hsien Lu, Yu-Chang Lee, Hung-Chen Wang, Chun-Chung Lui, Yu-Fan Cheng, Yi-Ting Shih, Ching-Po Lin*. 2009 “White matter damage in carbon monoxide intoxication assessed in vivo using diffusion tensor MRI” American Journal of Neuroradiology, Jun; 30(6): 1248-55.
2009 Meng-Rui Lee, Yu-Ming Chuang, Wen-Jone Chen, Ching-Po Lin. 2009 “Meticulous blood pressure control is mandatory for symptomatic primitive trigeminal artery” Am J Emerg Med, 27 (5) pp. 634.e5-7.
2009 Wei-Ta Chen, Shuu-Jiun Wang, Jong-Ling Fuh, Ching-Po Lin, Yu-Chieh Ko, Yung-Yang Lin. 2009 “Peri-ictal Normalization of Visual Cortex Excitability in Migraine: an MEG Study” Cephalalgia, 29: 1202-1211.
2009 Xiujuan Geng, Thomas J. Ross, Wang Zhan, Hong Gu, Yi-Ping Chao, Ching-Po Lin, Gary E. Christensen, Norbert Schuff, Yihong Yang. 2009 “Diffusion MRI registration using orientation distribution functions” Inf Process Med Imaging 21: 626-37.
2009 Yu-Ming Chuang, Ching-Po Lin, Ho-Fai Wong, Yeu-Jhy Chang, Chien-Hung Chang, Ting-Yu Chang, Tai-Cheng Wu, Hsiu-Chuan Wu, Tsong-Hai Lee. 2009 “Plasticity of Circle of Willis: A longitudinal Observation of Flow Patterns in the circle of Willis One Week After Stenting for Severe Internal Carotid Artery Stenosis” Cerebrovascular Diseases, Apr 24; 27(6): 572-578.
2009 Yu-Ming Chuang, Chien-Chih Chen, Ching-Po Lin. 2009 “Vertebral artery hypoplasia may contribute to abnormal vestibular evoked myogenic potential” Acta Neurol Taiwan, Jun; 18(2): 113-7.
2009 Ya Mei Bai, Kun-Hsien Chou, Ching-Po Lin*, I-Yun Chen, Cheng-Ta Li, Yang Kai Chun, Tung-Ping Su*. 2009 “White Matter Abnormalities in Schizophrenia Patients with Tardive Dyskinsia: A Diffusion Tensor Image Study” Schizophrenia Research, Apr; 109(1-3): 167-181.
2009 Yawei Cheng, Kun-Hsien Chou, Jean Decety, I-Yun Chen, Daisy Hung, Ovid Jyh-Lang Tzeng, Ching-Po Lin*. 2009 “Sex Differences in the Neuroanatomy of Human Mirror-Neuron System: a Voxel-Based Morphometric Investigation” Neuroscience, Jan; 158(2): 713–720.
2008 Kuan-Hung Cho, Chun-Hung Yeh, Jacques-Donald Tournier, Yi Ping Chao, Jyh-Horng Chen*, Ching-Po Lin*. 2008 “Evaluation of the accuracy and angular resolution of Q-ball imaging” NeuroImage, Aug 1; 42(1): 262-271.
2008 J-Donald Tournier, Chun-Hung Yeh, Fernando Calamante, Kuan-Hung Cho, Alan Connelly, Ching-Po Lin*. 2008 “Resolving crossing fibres using constrained spherical deconvolution: validation using diffusion weighted imaging phantom data” NeuroImage, Aug 15; 42(2): 617-625.
2008 Chun-Hung Yeh, Kuan-Hung Cho, Hsuan-Cheng Lin, Jiun-Jie Wang, Ching-Po Lin*. 2008 “Reduced Encoding Diffusion Spectrum Imaging Implemented with a Bi-Gaussian Model” IEEE Transactions on Medical Imaging, Oct; 27(10): 1415-24.
2008 Yi-Ping Chao, Jyh-Horng Chen, Kuan-Hung Cho, Chun-Hung Yeh, Kun-Hsien Chou, Ching-Po Lin*. 2008 “A Multiple Streamline Approach to High Angular Resolution Diffusion Tractography” Medical Engineering & Physics, Oct; 30(8): 989–996.
2008 Yu-Ming Chuang, Chih-Yang Liu, Po-Jung Pan, Ching-Po Lin*. 2008 “Posterior Communicating Artery Hypoplasia might Contribute to Acute Ischemic Stroke in the Absence of Carotid Artery Occlusion” Journal of Clinical Neuroscience, Dec; 15(12): 1376-1381.
2008 Ching-Po Lin, Wan-Yuo Guo, Kun-Hsien Chou, Ming-Teh Chen, Min-Hsiung Chen, Yu-Shu Yen, Yi-Ping Chao, Donald Ming-Tak Ho. 2008 “Peri-tumoral Fractional Anisotropy Mapping as a Prognosticator and Treatment Guidance of Brain Tumors: A Feasibility Study” Journal of Medical and Biological Engineering, Sep; 28 (3): 139-145.
2008 Yawei Cheng, Po-Lei Lee, Chia-Yen Yang, Ching-Po Lin, Jean Decety. 2008 “Gender Differences in the Mu Rhythm of the Human Mirror Neuron System” PLoS ONE, May 7; 3(5): e2113, 1-7.
2008 Yawei Cheng, Chia-Yen Yang, Ching-Po Lin, Po-Lei Lee, Jean Decety. 2008 “The Perception of Pain in Others Suppresses Somatosensory Oscillations: A Magnetoencephalography Study” NeuroImage, May 1; 40(4): 1833-1840.
2008 Erick J. Canales-Rodríguez, Yasser Alemán-Gómez, Ching-Po Lin, Yasser Iturria-Medina, Pedro A. Valdés-Hernández, Lester Melie-García. 2008 “A Bayesian framework to identify principal intravoxel diffusion profiles based on Diffusion-Weighted MR Imaging” NeuroImage, Aug 15; 42(2): 750-770.
2008 Erick Jorge Canales-Rodríguez, Lester Melie-García, Yasser Iturria-Medina, Eduardo Martínez-Montes, Yasser Alemán-Gómez, Ching-Po Lin. 2008 “Inferring Multiple Maxima in Intravoxel White Matter Fiber Distribution” Magnetic Resonance in Medicine, Sep; 60(3): 616-630.
2008 Jiun-Jie Wang, Yu-Chun Lin, Yau-Yau Wai, Hao-Li Liu, Ching-Po Lin, Ying-Zu Huang. 2008 “Visualization of the coherence of the principal diffusion orientation: an eigenvector-based approach” Magnetic Resonance in Medicine, 59(4): 764-70.
2008 Yu-Ming Chuang, Yuan-Chung Hwang, Ching-Po Lin*, Chih-Yang Liu. 2008 “Toward A Further Elucidation: Role of Vertebral Artery Hypoplasia in Migraine with Aura” European Neurology, 59(3-4): 148-151.
2008 林庆波,大脑神经网络:凡走过必留下痕迹,2008,科学人四月刊
2008 林庆波、江品仪、赵一平,扩散磁振造影之发展与应用,2008,科仪新知四月刊
2007 Yu-Ming Chuang, Chih-Yang Liu, Po-Jung Pan, Ching-Po Lin*. 2007 “Anterior Cerebral Artery A1 Segment Hypoplasia May Contribute to A1 Hypoplasia Syndrome” European Neurology, Jan 19; 57(4): 208-211.
2007 Yawei Cheng, Ching-Po Lin, Ho-Ling Liu, Yuan-Yu Hsu, Kun-Eng Lim, Daisy Hung, Jean Decety. 2007 “Expertise Modulates Pain Perception in Others” Current Biology, Oct 9; 17(19): 1708-1713.
2007 Yawei Cheng, Jean Decety, Ching-Po Lin, Jen-Chuen Hsieh, Daisy Hung, Ovid J.L. Tzeng. 2007 “Sex differences in spinal excitability during observation of bipedal locomotion” Neuroreport, 18(9): 887-890.
2006 Shih-Hwa Chiou, Chung-Lan Kao, Han-Tso Lin, Wen-Ser Tseng, Ren-Shyan Liu, Chen-Fun Chung, Hung-Hai Ku, Ching-Po Lin, Tai-Tong Wong. 2006 “Monitoring the Growth Effect of Xenotransplanted Human Medulloblastoma in Immunocompromised Mice Model Using In Vitro and Ex Vivo Green Fluorescent Protein Imaging” Childs Nervous System, 22: 485-490.
2003 Ching-Po Lin, Van J. Wedeen, Ching Yao, Jyh-Horng Chen, Wen-Yih I. Tseng. 2003. “Validation of Diffusion Spectrum Magnetic Resonance Imaging with Registered Manganese-enhanced Optic Tracts and Phantom” NeuroImage, Jul; 19(3): 482-495.
2001 Ching-Po Lin, Wen-Yih Isaac Tseng, Hui-Cheng Cheng, Jyh-Horng Chen. 2001. “Validation of Diffusion Tensor Magnetic Resonance Axonal Fiber Imaging with Registered Manganese-enhanced Optic Tracts” NeuroImage, Nov; 14(5): 1035-1047.