李 怡萱
基础神经研究团队
姓名 李 怡萱
电子邮件 yhlee3@ym.edu.tw
联络电话 02-2826-7067
POSITION TITLE/AFFILIATIONS 国立阳明大学 特聘教授 (2017-2019)

国立阳明交通大学 教授 (2010-迄今)

台北医学大学医学系生理学科 教授 (2003-2010)

台北医学大学医学系生理学科 副教授 (1995-2003)

长庚纪念医院整形外科 副研究员 (1994-1995)
EDUCATION/TRAINING 美国堪萨斯大学生理暨细胞生物系 博士 (1993)

台湾大学农业化学系 学士 (1988)
研究专长 Molecular and cellular neurobiology in neurotraum and neurodegenerative diseases.
研究概况 1.探讨多重环境压力之交互作用影响大脑发育与神经退化之分子机制。多重环境压力包括压力荷尔蒙糖皮质素及其受体 (glucocorticoid receptor)、环境荷尔蒙及其受体芳香烃受体(aryl hydrocarbon receptor)、及低氧及低氧诱发因子(hypoxia-inducible factors)。
2.探讨神经生长蛋白GAP43在神经系统发育及神经损伤后复原过程中,对突触塑性及神经胶细胞活性之影响。
3.探讨中枢神经白质损伤之神经保护机制。
年度 论文名称
2018 Huang HJ, Wang YT, Lin HC, Lee YH*, Lin AM*. Soluble Epoxide Hydrolase Inhibition Attenuates MPTP-Induced Neurotoxicity in the Nigrostriatal Dopaminergic System: Involvement of α-Synuclein Aggregation and ER Stress. MOLECULAR NEUROBIOLOGY. 2018; 55(1):138-144.
2017 Huang SL, Chang CW, Lee YH, Yang FY*. Protective Effect of Low-Intensity Pulsed Ultrasound on Memory Impairment and Brain Damage in a Rat Model of Vascular Dementia. RADIOLOGY. 2017; 282(1):113-122.
2017 Chou CC, Modi JP, Wang CY, Hsu PC, Lee YH*, Huang KF, Wang AH*, Nan C, Huang X, Prentice H, Wei J, Wu JY*. Activation of Brain L-glutamate Decarboxylase 65 Isoform (GAD65) by Phosphorylation at Threonine 95 (T95). MOLECULAR NEUROBIOLOGY, 2017; 54(2):866-873.
2016 Hung CC, Lin CH, Chang H, Wang CY, Lin SH, Hsu PC, Sun YY, Lin TN, Shie FS, Kao LS, Chou CM, Lee YH*. Astrocytic GAP43 induced by the TLR4/NF-κB/STAT3 axis attenuates astrogliosis-mediated microglial activation and neurotoxicity. JOURNAL OF NEUROSCIENCE, 2016; 36(6):2027-43.
2015 Wang CY, Lin HC, Song YP, Hsu YT, Lin SY, Hsu PC, Lin CH, Hung CC, Hsu MC, Kuo YM, Lee YJ, Hsu CY, Lee YH*. PKC-dependent GAP43 phosphorylation regulates gephyrin aggregation at developing GABAergic synapses. MOLECULAR AND CELLULAR BIOLOGY 2015; 35(10): 1712–1726.
2015 Lee YH*, Lin CH, Hsu PC, Sun YY, Huang YJ, Zhuo JH, Wang CY, Gan YL, Hung CC, Kuan CY, Shie FS*. Aryl hydrocarbon receptor mediates both proinflammatory and antiinflammatory effects in lipopolysaccharide-activated microglia. GLIA 2015; 63(7):1138-1154.
2013 Sun YY, Lin SH, Lin HC, Hung CC, Wang CY, Lin YC, Lien CC, Kuan CY, Lee YH*. Cell type-specific dependency on the PI3K/Akt signaling pathway for the endogenous Epo and VEGF induction by baicalein in neurons versus astrocytes.PLoS One 2013; 8(7):e69019.
2011 Lin MS, Hung KS, Chiu WT, Sun YY, Tsai SH, Lin JW,Lee YH*. Curcumin enhances neuronal survival in N-methyl-D-aspartic acid toxicity by inducing RANTES expression in astrocytes via PI-3K and MAPK signaling pathways. PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATYR 2011;35(4):931-938.
2011 Lin MS, Sun YY, Chiu WT, Chang CY, Hung CC, Shie FS, Tsai SH, Lin JW, Hung KS, Lee YH*. Curcumin attenuates the expression and secretion of RANTES following spinal cord injury in vivo and lipopolysaccharide-induced astrocyte reactivation in vitro. JOURNAL OF NEUROTRAUMA 2011;28:1259-1269.
2010 Sun YY, Wang CY, Hsu MF, Juan SH, Chang CY, Chou CM, Yang LY, Hung KS, Xu J, Lee YH*, Hsu CY*. Glucocorticoid protection of oligodendrocytes against excitotoxin involving hypoxia-inducible factor-1α in a cell type-specific manner. JOURNAL OF NEUROSCIENCE 2010;30(28):9621-9630.
2010 Chang CY, Lee YH, Leu SJ, Wang CY, Wei CP, Hung KS, Pai MH, Tsai MD, Wu CH*. CCL18/PARC expression in the central nervous system with special reference to traumatic brain injuries and neoplastic disorders. NEUROSCIENCE 2010;165:1233-1243.
2009 Lin CH, Chen CC, Chou CM, Wang CY, Hung CC, Chen JY, Chang HW, Chen YC, Yeh GC, Lee YH*. Knockdown of the aryl hydrocarbon receptor attenuates excitotoxicity and enhances NMDA-induced BDNF expression in cortical neurons. JOURNAL OF NEUROCHEMISTRY 2009;111:777-789.
2008 Lin CH, Juan SH, Wang CY, Sun YY, Chou CM, Chang SF, Hu SY, Lee WS, Lee YH*. Neuronal activity enhances aryl hydrocarbon receptor-mediated gene expression and dioxin neurotoxicity in cortical neurons. JOURNAL OF NEUROCHEMISTRY 2008;104:1415-1429.
2008 Liu WL, Lee YH, Tsai SY, Hsu CY, Sun YY, Yang LY, Tsai SH, Yang WCV*. Methylprednisolone inhibits the expression of glial fibrillary acidic protein and chondroitin sulfate proteoglycans in reactivated astrocytes. GLIA 2008;56:1390-1400
2007 Tsai SY, Yang LY, Wu CH, Chang SF, Hsu CY, Wei CP, Leu SJ, Liaw J, Lee YH*, Tsai MD.. Injury Induced JAK/PKC-Dependent Phosphorylation of GAP-43 and STAT3 for Neurite Growth in Dorsal Root Ganglion. JOURNAL OF NEUROSCIENCE RESEARCH 2007;85:321-331.
2005 Chang SF, Sun YY, Yang LY, Tsai SY, Hu SY, Lee WS, Lee YH*. Bcl-2 gene family expression in the brain of rat offspring after gestational and lactational dioxin exposure. ANNALS OF THE NEW YORK ACADEMY OF SCIENCES 2005;1042:471-480.
2003 Lee HH, Yang LL, Wang CC, Hu SY, Chang SF, Lee YH*. Differential effects of natural polyphenols on neuronal survival in primary cultured central neurons against glutamate- and glucose deprivation-induced neuronal death. BRAIN RESEARCH. 2003; 986(1-2):103-13.
2000 Lee YH*, Fang KM, Yang CM, Hwang HM, Chiu CT, Tsai W. Kainic acid-induced neurotrophic activities in developing cortical neurons. JOURNAL OF NEUROCHEMISTRY. 2000; 74(6):2401-11.
发表日期 专利名称 专利编号 专利国别 着作人
2012/07/27 AN ISOLATED TRANSGENIC MAMMALIAN NEURAL CELL FOR DETECTION OF A SAMPLE CONTAINING A CHEMICAL SUBSTANCE DAMAGE TO NEUROLOGICAL SYSTEM OR SELECTION OF DRUGS FOR TREATING NEURODEGENERATIVE DISORDERS. US 8,211,695. US Yi-Hsuan Lee, Chen-Yu Wang, Shu-Hui Juan, Wen-Liang Chen, Kuo-Sheng Hung, Chun-Hua Lin.
2013/07/27 检测损害或影响神经系统之化学物质样品及筛选治疗神经系统疾病之经分离之转殖基因哺乳动物神经细胞 发明第I401434号 中华民国 李怡萱,王震宇,阮淑慧,陈文亮,洪国盛, 林君桦