杨 静修
基础神经研究团队
姓名 杨 静修
电子邮件 cchyang@ym.edu.tw
联络电话 (02)2826-7058
POSITION TITLE/AFFILIATIONS 2006/08- 教授 国立阳明交通大学 脑科学研究所
2007/06- 主任 国立阳明交通大学 睡眠研究中心
2005/08-2006/07 教授兼所长 慈济大学 整合生理暨临床科学研究所
2000/08-2005/07 副教授兼科主任 慈济大学 生理学科
2001/06-2006-07 教授 慈济大学 生理学科 (教字第11422号)
1997/08-2001/05 副教授 慈济医学暨人文社会学院 生理学科
1996/08-1997/07 助理教授 慈济医学暨人文社会学院 生理学科 (副字第23740号)
EDUCATION/TRAINING 1991/09-1995/06 博士 阳明大学 生理学研究所
毕业论文: Neurobiologic Role of Hypoglossal Nucleus in Central AngiotensinIII-Induced Drinking Response in Rats
1989/09-1991/06 硕士 阳明医学院 药理学研究所
毕业论文:Differential Drinking Responses to Chronic Central Infusion of Angiotensin III in Spontaneously Hypertensive and Normotensive Rats
1984/09-1988/06 学士 私立台北医学院 药学系
研究专长 Neural Physiology, Pharmacology
研究概况 一、动脉压变异性分析与应用 (呼吸影响波动,BHF;血管运动影响波动,BLF)

BHF:动脉压呼吸波动与自律神经功能之关系,长久以来一直为学者所忽视。本研究室1999年论文1 首次证明动脉压呼吸相关律动可做为评估大鼠之心脏交感神经活性。另两篇论文更详细探讨此频率成份来源及其机转2, 3。另外,动物失血时会引发此波动功率之上升具专一性,研究结果发现失血所引发之现象与自律神经之β-交感神经活性具极密切之相关4;由于动脉压讯号于医院中容易取得,故于人类研究亦证明此波动与β-交感神经活性有关5,将来更有非侵体性测量技术发展之可能。故此部分论文可提供一项发展潜力极高之心脏交感神经功能或失血现象评估方法。

BLF:本研究室曾参与动脉压低频律动之临床应用及其来源之探讨,已知其与交感神经对血管调控有关。高血压疾病一直威胁人类健康且名列十大死因之一,然至今对它的了解仍然不多。事实上血压的调节乃一动态之平衡,综观多数研究皆以静态方式探讨,恐失去许多重要讯息。吾人尝试以动态角度观察SHR与正常血压对照鼠 (WKY) 之差异并研究其延脑动态控压能力 (或谓血管对神经之反应性) 之差异,吾人首度证明SHR的延脑动态控压能力强于WKY鼠,并有较快之反应速率,更详细洞悉高血压形成原因6。并进一步探讨交感神经于其间扮演之角色。另本研究室成功开发自由活动大鼠之动脉压变异性分析研究模式7,于此动物模式亦得到类似之研究结果与结论。但此现象仅独特出现于睡眠时期,更指出睡眠研究之重要性,详见第三部份的叙述。

二、心率变异性 (HRV) 之分析与应用

由于讯号取得较易,心率变异性之研究开发较早。本研究室以自制之心电放大器 (郭教授设计) 及配合撰写分析程式 (郭教授撰写),与公卫专家合作将记录到的台湾南投县渔池乡中老年等数千人之资料作分析,完整评估健康人心脏自律神经之功能参数,发现五十岁前男性在休息状态下之基础交感神经活性比女性高;相反的,女性之基础副交感神经活性则比男性高。但此现象于五十岁后男女差别即消失8,推论此现象与女性五十岁左右时停经现象有关;其后与地区卫生所合作,更针对此问题探索同年龄层五十岁左右之男、女自律神经活性差异之谜。确认女性内生性性激素于停经前扮演重要之角色。女性停经后若补充雌激素则可回复至停经前之自律神经功能表现9;之后以自由活动大鼠之研究模式,探讨内生性雌激素之角色,也确认雌激素其促进副交感基础活性之作用10;此方面研究也与传统医学医师合作,发现针灸对停经妇女之自律神经失调具改善效果。有趣的是,针灸亦能一并改善停经后之睡眠问题11;应用到妇产科子颠前症怀孕病人,发现病人有交感活性过度兴奋而副交感活性异常降低现象,提供临床治疗一重要讯息12;针炙应用之研究也发现,由于人面临压力或各种病征时,往往增强交感而抑制副交感神经活性;而针刺四神囱穴可有效加强副交感且抑制交感神经活性,可提供临床治疗上方便且少伤害之重要方法13。与肠胃科合作开发评估人类及大鼠,胃之自律神经功能的新方法14-16;与神经内科确认中风对自律神经功能的影响17 与神经外科探索癫痫病人的自律神经功能变化 18-20;与泌尿科探索心脏自律神经系统于男性性功能障碍之角色21;与精神科及药师探索人类及大鼠之精神疾病、用药情况及治疗对心脏自律神经功能之影响22-31;与精神科探索实习医师之压力问题32-34。另也了解美沙冬对毒物成瘾的替代疗法对心脏自律神经功能之影响26, 28。另人格特质与自律神经功能也有一定关系35,36。另外,利用控制呼吸频率与吸气及呼气时间比例,来探究各项HRV参数及感压反射灵敏度的变化及影响,详细了解HRV及感压反射灵敏度设计实验时,呼吸影响的重要性37-40。

三、人与大鼠之睡醒与自律神经相关研究

吾人现担任阳明大学睡眠研究中心主任,积极与基础与临床研究者合作,利用过去已确立的人及自由活动大鼠之研究模式41, 42,而成为本研究室近年的研究主轴。过去本研究室可量测到人及大鼠之心电讯号,并详细观察睡眠中自律神经之变化43, 44,也详细探讨其中自律神经功能与睡醒之因果关系45,并进一步解答自律神经功能于睡及醒调控之正常生理及可能病理机转。研究发现有 (1) 跟传统医学合作发现停经妇女的睡眠问题与自律神经调控实具高度关连,并可透过针灸适度缓解自律神经之异常,亦能有效改变睡眠品质11。(2) 护理人员值班 (长期值夜或轮班) 的睡眠自律神经功能变化46-48,提醒值班设计的重要性。(3) 探讨SHR之睡眠与自律神经功能变化,SHR睡眠结构与WKY具明显差异性,并具明显睡眠片断现像49-51,另特别于睡眠时才出现循环自律神经调控缺陷51。Circulation期刊还特别为我们的研究设计及重要发现写评论 52。也找出SHR之睡眠异常可能与交感神经1-adrenergic system过度兴奋有关53。近年我们更建立完全的无线大鼠模式,除在测量时动物能更自由、更无压力外,亦使记录时间可以延长并有机会 (4) 了解超过24小时之正常生理律动54及改变光照造成之影响 (结果整理中),可以详细在控制环境下探讨所谓时差等因素对人的可能影响;(5) 本实验室更自制遥控电刺激模式,电兴奋血管运动中枢 (rostro ventral lateral medulla, RVLM),证明正常血压鼠可因RVLM之刺激使睡眠模式转变为类似SHR之片断式睡眠。上述之研究结果可间接解答SHR可能是因为RVLM 过度兴奋造成睡眠片断现像55,电刺激RVLM造成醒觉的发现,期刊也特别为我们的研究及发现写评论 56 (6) 利用大鼠模式,仔细了解人类一日于夜间睡眠时血压下降 (blood pressure dipping, BP dipping) 在正常生理之角色,其可能之机转。确认其中醒睡于BP dipping之比重佔超过90%,而日夜节律则仅佔不到10% 的影响,进一步探讨BP nondipping之可能病理原因57;另,已知睡眠后期是全天中最高好发心循环疾病的时间,我们也确立了与人类相似之大鼠研究模式,了解此期间可能与睡眠后期之睡眠结构不稳定及自律神经系统偏向交感神经活性有关53;(7) 另,利用人类及大鼠之动物模式分别进行研究冬季好发心循环疾病的可能机转,实验设计特别为台湾冬季低温模式,且已确认许多可能机转58;(8) 除探索好发心循环疾病的问题,我们也试着了解运动降血压之机转,希望提出更好的预防及治疗高血压模式 (大鼠及人都已有结果,一篇投稿中,一篇撰写中)。目前正积极探讨上述各因子于高血压之特异表现。(9) 小鼠的研究模式已完成研究技术之建立,目前论文正投稿中。此方面更开启与分子生物领域研究合作之可能。(10) 另我们也发现自觉入睡困难者其白天副交感神经活性较弱及交感神经活性偏高,入睡过程中脑波高频波活性也偏高于睡眠品质良好者,显示入睡困难问题与皮质过度兴奋有关;而慢速 (0.1 Hz) 定量呼吸训练,可有效降心率及调升整体自律神经功能,同时并能有效改善客观睡眠品质,特别是缩短入睡时间以及提升睡眠效度59,本论文也提出入睡困难失眠者有效的非药物治疗方法,此议题也将是本实验室未来探索睡眠问题的主轴。(11) 我们与床枕公司合作探讨以躺床之肌力测试来选床,发现短期间睡在选出较适的床上,可有效改善循环神经调控及感压反射灵敏度60,突显睡眠时床垫选择的重要性。

除了睡眠研究,我们也将视野跨到人非睡眠时期之白天自律神经功能变化,并看午睡对自律神经功能的影响及其可能生理意义 (论文投稿中)。近年更将研究技术方向拓展到云端人性化之睡眠 (以研究室自行开发之活动计量测) 及心循环系统等功能测量,使睡眠及各式生理参数的记录更生活化更普及化。不用等到研究成果出来,受试者只要参与监测生理讯号即对自己的身体保健就能多一层了解及关心,软硬件架构几乎完成,目前正积极进行各式人体试验。

四、正在运动中大鼠之脑波与自律神经研究

  因本研究室近几年已建立自由活动大鼠模式之脑波、肌电波、血压及心电波等多讯号记录,我们将探索范围延伸至活动状态下,特别探索正在运动中大鼠的脑波、肌电波及心电波。我们已成功记录大鼠进行等速跑步机运动时的脑波及心电讯号,发现在运动过程中大脑枕叶theta频带成份会增加,而已知此频带可能与认知能力有关61, 62。由于这是之前许多运动研究上较少能做到的记录及各式控制,所以在这方面研究上仍拥有许多优势。并记录大鼠海马回之脑波发现,跑步运动可依照theta波成分作分期,并借此探讨感觉运动整合的过程。另,亦记录自由活动之滚轮运动大鼠,探讨速度与theta波之关系63。最后借由两种运动模式探讨自愿运动与被动运动之差异,发现两种运动虽速度及活动力都不同。经过分析比较后,我们认为theta波的高频成分可能与心理压力有关64。此外我们也进一步探讨老化对运动过程中脑波的影响,发现老化会减低运动对脑波的反应,此现象仅于运动中才观察的到65。再者,我们亦观察老化对运动过程中大鼠心率变异性之影响,结果暗示老化为造成心脏调控能力简化之因素之一,是值得注意的,此部份正投稿中。另透过记录在水管内移动之大鼠生理讯号,以厘清视觉及身体活动对theta波产生之贡献66。过去我们确认SHR的运动训练确实可减缓随年龄增加的高血压及睡眠问题 (投稿中),今年拟更进一步了解SHR的运动训练是否也可防止因血压上升引发的学习记忆能力缺陷的问题,其中自律神经系统、睡眠及脑波成份等各生理参数是否亦扮演重要角色。
年度 论文名称
2016 Li, J. Y., Kuo, T. B. J., Yang, C. C. H.* (2016) Aged rats show the dominant modulation on lower frequency of hippocampal theta rhythm during running. Experimental Gerontology 83:63-70
2016 Kuo, T. B. J. †, Lai, C. T. , Chen, C. Y. †, Yang, Y. C., Yang, C. C. H.* (2016) The high-frequency component of heart rate variability during extended wakefulness is closely associated with the depth of the ensuing sleep in C57BL6 mice. Neuroscience 330: 257-66
2016 Lin, Y. C., Lin, Y. H., Lo, M Z., Peng, C. K., Huang, N. E., Yang, C. C. H., Kuo, T. B. J.* (2016) Novel application of multi dynamic trend analysis as a sensitive tool for detecting the effects of aging and congestive heart failure on heart rate variability. Chaos 26:023109
2016 Hong C. H. †, Kuo, T. B. J. †, Huang B. C., Lin Y. C., Kuo K. L., Chern C. M., Yang, C. C. H.* (2016) Cold exposure can induce an exaggerated early-morning blood pressure surge in young prehypertensives. PLoS One.11(2):e0150136
2016 Kuo, T. B. J. †, Chen C. Y. †, Hsu, Y. C., Yang, C. C. H.* (2016) EEG beta power and heart rate variability describe the association between cortical and autonomic arousal across sleep. Autonomic Neuroscience: basic and clinical 194:32-7
2016 Kuo, T. B. J. †, Li, J. Y. †, Kuo, H. K., Chern, C. M., Yang, C. C. H.* (2016) Differential changes and interactions of autonomic functioning and sleep architecture before and after 50 years of age. Age 38:5
2015 Huang W. L., Liao S. C., Kuo, T. B. J., Chang, L .R., Chen, Z. T., Chen, I. M., Yang, C. C. H.* (2015) The effects of antidepressants and quetiapine on heart rate variability. Pharmacopsychiatry [Epub ahead of print]
2015 Tsai, H. J. †, Kuo, T. B. J., Lin, Y. C. †, Yang, C. C. H.* (2015) The association between prolonged sleep onset latency and heart rate dynamics among young sleep-onset insomniacs and good sleepers. Psychiatry Research 230:892-898
2015 Lai, C. T., Chen, C. Y., Kuo, T. B. J., Chern, C. H., Yang, C. C. H.* (2015) Sympathetichyperactivity, sleep fragmentation and wake-related blood pressure surge during late-light sleep in spontaneously hypertensive rats. American Journal of Hypertension 29:590-7
2015 Wang, Y. B., Kuo, T. B. J., Lai C.T., Yang, C. C. H.* (2015) Effects of breathing frequency on the heart rate deceleration capacity and heart rate acceleration capacity. European Journal of Applied Physiology 115:2415-2420
2015 Huang W. L., Hwang B. T., Lai C. T., Li J. Y., Kuo, T. B. J., Yang, C. C. H.* (2015) Is heart rate variability related to season of birth? Clinical Cardiology 38:407-412
2015 Lin Y. H., Lin Y. C., Lee Y. H., Lin P. H., Lin S. H., Chang L. R., Tseng H. W., Yen L. Y., Yang, C. C. H., Kuo, T. B. J.* (2015) Time distortion associated with smartphone addiction: identifying smartphone addiction via a mobile application (App) Journal of Psychiatric Research 65:139-145
2015 Tsai, H. J., Kuo, T. B. J., Lee, G.-S., Yang, C. C. H.* (2015) Efficacy of paced breathing for insomnia: enhances vagal activity and improves sleep quality. Psychophysiology 52:388-396
2014 Wang, Y. B., Kuo, T. B. J., Yang, C. C. H.* (2014) A possible explanation for the effects of respiration on heart rate and blood pressure asymmetry. International Journal of Cardiology 174:805-807
2014 Kuo, T. B. J., Hong, C.-H., Hsieh, I.-T., Lee, G.-S., Yang, C. C. H.* (2014) Effects of cold exposure on autonomic changes during the last REM sleep transition and morning blood pressure surge in humans. Sleep Medicine 15:986-997
2014 Li, J.-Y., Kuo, T. B. J., Yen, J.-C., Tsai, S.-C., Yang, C. C. H.* (2014) Voluntary and involuntary running in the rat show different patterns of theta rhythm, physical activity and heart rate. Journal of Neurophysiology 111:2061-2070
2014 Wang, Y. P., Kuo, T. B. J., Yang, C. C. H.* (2014) Reply to Hejjel. Journal of Applied Physiology 116:710
2014 Kuo, T. B. J., Chen, C. Y., Wang, Y. P., Lane Y. Y., Mak, K. H., Yang, C. C. H.* (2014) The role of autonomic and baroreceptor reflex control in blood pressure dipping and non-dipping in rats. Journal of Hypertension 32:806-816
2013 Kuo, T. B. J., Li, J. Y., Lai, C. T., Huang, Y. C., Hsu, Y. C., Yang, C. C. H.* (2013) Effect of bedding system selected by manual muscle testing on sleep-related cardiovascular functions. Biomed Research International http://dx.doi.org/10.1155/2013/937986
2013 Wang, Y. P., Kuo, T. B. J., Lai, C. T., Chu, J. W., Yang, C. C. H.* (2013) Effects of respiratory time ratio on heart rate variability and spontaneous baroreflex sensitivity. Journal of Applied Physiology 115:1648-1655
2013 Chen, C. Y., Kuo, T. B. J., Hsieh, I. T., Yang, C. C. H.* (2013) Electrical stimulation of the rostral ventrolateral medulla promotes wakefulness in rats. Sleep Medicine 14:1076-1084
2013 Lin, Y. H., Ho, Y. C., Lin, S. H., Yeh, Y. H., Liu, C. Y., Kuo, T. B. J., Yang, C. C. H., Yang, A. C.* (2013) On-call duty effects on sleep-state physiological stability in male medical interns. Plos One 8:e65072
2013 Huang, S. S., Cheng, H., Tang, C. M., Nien, M. Y., Huang, Y. S., Lee, I. H., Yin, J. H., Kuo, T. B. J., Yang, C. C. H., Tsai, S. K.*, Yang, C. C. H.* (2013) Anti-oxidative, anti-apoptotic, and pro-angiogenic effects mediate functional improvement by sonic hedgehog against focal cerebral ischemia in rats. Experimental Neurology 247:680-688
2013 Liu, K. D., Shan, D. I., Kuo, T. B. J., Yang, C. C. H.* (2013) The effects of bilateral stimulation of the subthalamic nucleus on heart rate variability in patients with Parkinson’s disease. Journal of Neurology 260:1714-1723
2013 Huang, W. L., Chang, L. R., Kuo, T. B. J., Lin, Y. H., Chen, Y. Z., Yang, C. C. H.* (2013) Gender differences in personality and heart rate variability. Psychiatry Research 209:652-657
2013 Lin, Y. C., Chen, C. Y., Lin, S. H., Liu, C. H., Weng, W. H., Kuo, T. B. J. and Yang, C. C. H.* (2013) Gender differences in cardiac autonomic modulation during medical internship. Psychophysiology 50:521-527
2012 Wang, T. S.,†, Huang, W. L.†, Kuo, T. B. J., Lee, G. S. and Yang, C. C. H.* (2012) Inattentive and hyperactive preschool-age boys have lower sympathetic and higher parasympathetic activity.. Journal of Physiological Sciences 36:87-94
2012 Kuo, T. B. J., Lai, C. T., Chen, C. Y., Lee, G. S. and Yang, C. C. H.* (2012) Unstable sleep and higher sympathetic activity during late sleep periods of rats: implication for late sleep-related higher cardiovascular events. Journal of Sleep Research 22:108-118
2012 Huang, W. L., Chang, L. R., Kuo, T. B. J., Lin, Y. H., Chen, Y. Z. and Yang, C. C. H.* (2012) Impact of Antipsychotics and Anticholinergics on Autonomic Modulation in Patients with Schizophrenia. Journal of Clinical Psychopharmacology 33:170-177
2012 Hsieh, I. T., Yang, C. C. H., Chen, C. Y., Lee, G. S., Kao, F. J., Kuo K. L. and Kuo, T. B. J.* (2012) Uninterrupted wireless long-term recording of sleep patterns and autonomic function in freely moving rats. Journal of Medical and Biological Engineering 33:79-86
2012 Chen H. C., Yang, C. C. H. , Kuo, T. B. J., Su, T. P. and Chou, P.* (2012) Cardiac vagal control and theoretical models of co-occurring depression and anxiety: A cross-sectional psychophysiological study of community elderly. BMC Psychiatry 12:93
2012 Wang, Y. P., Kuo, T. B. J., Lai, C. T., Lee, G. S. and Yang, C. C. H.* (2012) Effects of breathing frequency on baroreflex effectiveness index and spontaneous bbaroreflex sensitivity derived by sequence analysis. Journal of Hypertension 30:2151-2158
2012 Kuo, T. B. J., Chen, C. Y., Lai, C. T., Chuan, T. Y., Wu, W. Y., Tsai, S. C. and Yang, C. C. H.* (2012) Sleep Disturbance among Spontaneously Hypertensive Rats is Mediated by an α1-Adrenergic Mechanism. American Journal of Hypertension 25:1110-1117
2012 Li, J. Y., Kuo, T. B. J., Hsieh, I. T. and Yang, C. C. H.* (2012). Changes in hippocampal theta rhythm and their correlations with speed during different phases of voluntary wheel running in rats. Neuroscience 213: 54-61
2012 Ya-Chun Chua†*, Cheryl C. H. Yang †, Ho-Tien Lin, Pin-Tarng Chen, Kuang-Yi Chang, Shun-Chin Yang and Kuo, T. B. J. (2012) Neonatal nociception elevated baseline blood pressure and attenuated cardiovascular responsiveness to noxious stress in adult rats. International Journal of Developmental Neuroscience 30:421-426
2012 Huang, S. S., Su, H. H., Kuo, T. B. J., Chen, C. Y., Lan, Y. Y., Liu, B. Y., Young, D. I., Tsai, S. C. and Yang, C. C. H.* (2012) Suppressing cardiac vagal modulation and changing sleep patterns in rats after chronic ischemic stroke injury. Autonomic Neuroscience-Basic and Clinical 169:116-123
2012 Kuo, T. B. J., Chen, C. Y., Hsu, Y. C. and Yang, C. C. H.* (2012) Performance of the frequency domain indices with respect to sleep staging. Clinical Neurophysiology 123:1338-1345
2012 Huang, W. L., Lin, Y. H., Kuo, T. B. J., Chang, L. R., Chen, Y. Z. and Yang, C. C. H.* (2012) Methadone-mediated autonomic functioning of male patients with heroin dependence: the influence of borderline personality pattern. PLoS ONE 7:e37464
2012 Wang, Y. C., Chen, C. Y., Kuo, T. B. J., Lai, C. J. and Yang, C. C. H.,* (2012) The influences of antipsychotic agents on the heart rate variability in male WKY rats: implications for cardiovascular safety. Neuropsychobiology 65:216-226
2012 Chung, M. H., Kuo, T. B. J., Hsu, N., Chu, H., Chou, K. R. and Yang, C. C. H.* (2012) Recovery after three-shift work: relation to sleep-related cardiac neuronal regulation in nurses. Industrial Health 50:24-30
2012 Chang, L. R., Lin, Y. H., Kuo, T. B. J., Ho, Y. C., Chen, S. H., Wu Chang, H. C., Liu, C. M. and Yang, C. C. H.* (2012) Cardiac autonomic modulation during methadone therapy among heroin users: a pilot study. Progress in Neuro-Psychopharmacology & Biological Psychiatry 37:188-193
2012 Chen, P. L., Kuo, T. B. J., and Yang, C. C. H.* (2012) Parasympathetic activity correlates with early outcome in patients with large artery atherosclerotic stroke. Journal of the Neurological Sciences 314:57-61
2012 Lin, Y. H., Kuo, T. B. J., Ho, Y. C., Lin, S. H., Liu, C. Y. and Yang, C. C. H.* (2012) Physiological and psychological impacts on male medical interns of on-call duty. Stress 15:21-30
2011 Chang, L. R., Lin, Y. H., Kuo, T. B. J., Wu Chang, H. C., Liu, C. M., Liu, C. C., Hwu, H. G., and Yang, C. C. H.* (2011) Autonomic Modulation and Health-related Quality of Life among Schizophrenic Patients Treated with Non-intensive Case Management. PLoS ONE 6:e26378
2011 Chung, M. H., Kuo, T. B. J., Hsu, N., Chuo, K. R., Chu, H. and Yang, C. C. H.* (2011) Comparison of sleep-related cardiac autonomic function between rotating-shift and permanent night-shift workers. Industrial Health 49:589-596
2011 Kuo, T. B. J., Li, J. Y.†, Chen, C. Y., and Yang, C. C. H.* (2011) Changes in hippocampal theta activity during initiation and maintenance of running in the rat. Neuroscience 194:27-35
2011 Chen, S. Y., Yang, C. C. H., Kuo, T. B. J. and Harnod T.* (2011) Association of heart rate variability with clinical outcome in parkinsonian patients after subthalamic deep brain stimulation: A retrospective cohort study. Journal of the Formosan Medical Association 110:593-599
2011 Huang, Y. M., Yang, C. C. H., Lai, C. J. and Kuo, T. B. J.* (2011) The influence of autonomic interventions on the sleep-wake related changes in gastric myoelectrical activity in rats. Neurogastroenterology & Motility 23: 560-e208
2011 Kung, Y. Y., Yang, C. C. H., Chiu, J. H. and Kuo, T. B. J.* (2011) The relationship of subjective sleep quality and cardiac autonomic nervous system in postmenopausal women with insomnia under auricular acupressure. Menopause 18: 638-645
2011 Kuo, T. B. J., Yuan, Z. F., Lin, Y. S., Lin, Y. N., Li, W. S., Yang, C. C. H. and Lai, C. J.* (2011) Reactive oxygen species are the cause of the enhanced cardiorespiratory response induced by intermittent hypoxia in conscious rats. Respiratory Physiology & Neurobiology 175:70-79
2011 Chen, C. Y., Yang, C. C. H., Lin, Y. Y. and Kuo, T. B. J.* (2011) Locomotion-induced hippocampal theta is independent of visual information in rats during movement through a pipe. Behavioural Brain Research 216:699-704
2010 Chen, W. L., Tsai, T. H., Yang, C. C. H. and Kuo, T. B. J.* (2010) Effects of ephedra on autonomic nervous modulation in healthy young adults. Journal of Ethnopharmacology 130:563-568
2010 Chen, W. L., Tsai, T. H., Yang, C. C. H. and Kuo, T. B. J.* (2010) Acute effects of ephedra on autonomic nervous modulation in healthy young adults. Clinical Pharmacology and Therapeutics 88:39-44
2010 Kuo, T. B. J.†, Li, J. Y.†, Hsieh, S. S. Y., Chen, J. J., Tsai, C. Y., and Yang, C. C. H.* (2010) Effect of aging on treadmill exercise induced theta power in the rat. Age 32:297-308
2010 Kuo, T. B. J., Lai, C. T., Hsu, F. C., Tseng, Y. J., Li, J. Y., Shieh, K. R., Tsai, S. C., and Yang, C. C. H.* (2010) Cardiac neural regulation oscillates with the estrous cycle in freely moving female rats: the role of endogenous estrogens. Endocrinology 151:2613-2621
2010 Lai, I. C., Yang, C. C. H., Kuo, T. B. J., and Shieh, K. R.* (2010) Transcranial magnetic stimulation for auditory hallucination in severe schizophrenia: partial efficacy and acute elevation of sympathetic modulation. Psychiatry and Clinical Neurosciences 64:333-335
2010 Hsin, Y., Yang, C. C. H., Kuo, T. B. J., and Harnod, T.* (2010) Effects of chronic epilepsy on heart rate variability. Neural Regeneration Research 5:156-160
2010 Huang, Y. M., Yang, C. C. H., Lai, C. J., and Kuo, T. B. J.* (2010) Involvement of sympathetic function in the sleep-related change of gastric myoelectrical activity in rats. Journal of Sleep Research 19:192-200
2010 Kuo, H. K., Yang, C. C. H., Yu, Y. H., Tsai, K. T., Chen, C. Y.* (2010) Gender-specific association between self-reported sleep duration and falls in high-functioning older adults. Journals of Gerontology Series A: Biological Sciences and Medical Sciences 65:190-196
2010 Chen, H. C., Yang, C. C. H., Kuo, T. B. J., Su, T. P., and Chou, P.* (2010) Gender differences in the relationship between depression and cardiac autonomic function among community elderly. International Journal of Geriatric Psychiatry 25:314-322
2009 Sun, T. B.*, Kuo, T. B. J., and Yang, C. C. H. (2009) Power spectral analysis of perfusion signals on free radial forearm flap transplantation in humans. Microsurgery 29:636-643
2009 Sun, T. B.*, Kuo, T. B. J., and Yang, C. C. H. (2009) Nonparallel cutaneous microcirculatory responses to pharmacologic alterations of systemic arterial pressure in rats. Microsurgery 29:319-325
2009 Chung, M. H., Kuo, T. B. J., Hsu, N., Chu, H., Chou, K. R., and Yang, C. C. H.* (2009) Sleep and autonomic nervous system changes - enhanced cardiac sympathetic modulations during sleep in permanent night shift nurses. Scandinavian Journal of Work Environment & Health 35:180-187
2009 Kuo, T. B. J., and Yang, C. C. H.* (2009) Frequency domain analysis of electrooculogram and its correlation with cardiac sympathetic function. Experimental Neurology 217:38-45
2009 Kuo, T. B. J., Yang, C. C. H.*, and Huang, N. E. (2009) Quantification of Respiratory Sinus Arrhythmia Using Hilbert-Huang Transform. Advances in Adaptive Data Analysis 1:295-307
2009 Chen, C. J.†, Kuo, T. B. J.†, Tseng, Y. J., and Yang, C. C. H.* (2009) Combined cardiac sympathetic excitation and vagal impairment in patients with non-organic erectile dysfunction. Clinical Neurophysiology 120:348-352
2009 Harnod, T., Yang, C. C. H., Hsin, Y. L., Wang, P. J., Shieh, K. R., and Kuo, T. B. J.* (2009) Heart rate variability in patients with frontal lobe epilepsy. Seizure: European Journal of Epilepsy 18:21-25
2009 Chung, M. H., Chang, F. M., Yang, C. C. H., Kuo, T. B. J., and Hsu, N.* (2009) Sleep quality and morning ness-eveningness of shift nurses. Journal of Clinical Nursing 18:279-284
2008 Wang, Y. C., Yang, C. C. H., Bai, Y. M., and Kuo, T. B. J.* (2008) Heart rate variability in schizophrenic patients switched from typical antipsychotic agents to amisulpride and olanzapine: 3-month follow-up. Neuropsychobiology 57:200-205
2008 Yang, C. C. H., Yeh, I. T., Lai, H. Y., Chen, H. I., and Kuo, T. B. J.* (2008) Dynamic effects of respiration on aortic blood flow and its autonomic control in rats. Clinical and Experimental Pharmacology and Physiology 35:1294-1300
2008 Li, J. Y.†, Kuo, T. B. J.†, Hsieh, S. S., and Yang, C. C. H.* (2008) Changes in electroencephalogram and heart rate during treadmill exercise in the rat. Neuroscience Letters 434:175-178
2008 Kuo, T. B. J., Shaw, F. Z., Lai, C. J., and Yang, C. C. H.* (2008) Asymmetry in sympathetic and vagal activities during sleep-wake transitions. Sleep 31:311-320
2008 Lai, I. C.*, Yang, C. C. H., Kuo, T. B. J., Wang, Y. C., and Shieh, K. R. (2008) Immediate impact of electroconvulsive therapy on cardiac autonomic function in schizophrenia: A preliminary study. Schizophrenia Research 100:353-355
2008 Harnod, T., Yang, C. C. H., Hsin, Y. L., Wang, P. J., Shieh, K. R. and Kuo, T. B. J.* (2008) Heart rate variability in children with refractory generalized epilepsy. Seizure: European Journal of Epilepsy 17:297-301
2008 Yi, C. H., Chen, C. L.*, Kuo, T. B. J. and Yang, C. C. H. (2008) The effect of acid suppression on sleep and cardiac autonomic regulation in GERD. Hepatogastroenterology 55:1649-1652
2008 Chen, C. L.*, Yi, C. H., Kuo, T. B. J. and Yang, C. C. H. (2008) Effect of acid suppression on gastric myoelectrical activity in GERD. Hepatogastroenterology 55:1353-1355
2008 Fu, C. H., Yang, C. C. H., Lin, C. L. and Kuo, T. B. J.* (2008) Alteration of cardiovascular autonomic functions by vegetarian diets in postmenopausal women is related to LDL cholesterol levels. Chinese Journal of Physiology 51:100-105
2007 Lee, G. S., Hsiao, T. Y., Yang, C. C. H. and Kuo, T. B. J.* (2007) Effects of speech noise on ocal fundamental frequency using power spectral analysis. Ear and Hearing 28:343-350
2007 Chen, C. L., Yang, C. C. H. and Kuo, T. B. J.* (2007) Transfer function analysis of heart rate variability correlated with gastric myoelectrical activity using a liquid nutritional meal compared to water: are they different? Chinese Journal of Physiology 50:271-276
2006 Chen, K. Y., Chen, C. L.*, Yang, C. C. H., Kuo, T. B. J. (2006) Cardiac autonomic dysregulation in patients with acute hepatitis. American Journal of the Medical Sciences 332:164-167
2006 Chen, C. L.*, Orr, W. C., Yang, C. C. H. and Kuo, T. B. J. (2006) Cardiac autonomic regulation differentiates reflux disease with and without erosive esophagitis. Scandinavian Journal of Gastroenterology 41:1001-1006
2006 Fu, C. H., Yang, C. C. H. and Kuo, T. B. J.* (2006) Age-Related Changes in Cerebral Hemodynamics and Their Correlations with Cardiac Autonomic Functions. Neurological Research 28:871-876
2006 Lai, C. J., Yang, C. C. H., Hsu, Y. Y., Lin, Y. N. and Kuo, T. B. J.* (2006) Enhanced sympathetic activity and decreased baroreflex sensitivity are associated with intermittent hypoxia-induced systemic hypertension in conscious rats. Journal of Applied Physiology 100:1974-1982
2006 Lee, G. S., Yang, C. C. H. and Kuo, T. B. J.* (2006) Voice low tone to high tone ratio: a potential quantitative index for vowel [a:] and its nasalization. IEEE Transactions on Biomedical Engineering 53:1437-1439
2006 Sun, T. B., Yang, C. C. H. and Kuo, T. B. J.* (2006) Effect of Hyperbaric oxygen on Cardiac Neural Regulation in Diabetic Individuals with Foot Complications. Diabetic Medicine 23:360-366
2006 Sun, T. B., Yang, C. C. H., Lai, C. J. and Kuo, T. B. J.* (2006) Time course of cardiovascular neural regulation during programmed 20-sec apnea in rats. Critical Care Medicine 34:765-770
2006 Fu, C. H., Yang, C. C. H., Lin, C. L. and Kuo, T. B. J.* (2006) Effects of long-term vegetarian diets on cardiovascular autonomic functions in healthy postmenopausal women. American Journal of Cardiology 97:380-383
2005 Kuo, T. B. J.†, Lai, C. J.†, Huang, Y. T. and Yang, C. C. H.* (2005) Regression analysis between heart rate variability and baroreflex-related vagus nerve activity in rats. Journal of Cardiovascular Electrophysiology 16:864-869
2005 Fu, C. H., Yang, C. C. H. and Kuo, T. B. J.* (2005) Effects of different classes of antihypertensive drugs on cerebral hemodynamics in elderly hypertensive patients. American Journal of Hypertension 18:1621-1625
2005 Lee, G. S., Yang, C. C. H., Wang, C. P. and Kuo, T. B. J.* (2005) Effect of nasal decongestion on voice spectrum of a nasal consonant-vowel. Journal of Voice 19:71-77
2005 Kuo, T. B. J. and Yang, C. C. H.* (2005) Sleep-related changes in cardiovascular neural regulation in spontaneously hypertensive rats. Circulation 112:849-854
2005 Chen, H. Y.†, Kuo, T. B. J.†, Shaw, F. Z., Lai, C. J. and Yang, C. C. H.* (2005) Sleep-related vagotonic effect of zolpidem in rats. Psychopharmacology (Berl) 181:270-279
2004 Kuo, T. B. J. and Yang, C. C. H.* (2004) Scatterplot analysis of EEG slow-wave magnitude and heart rate variability: an integrative exploration of cerebral cortical and autonomic functions. Sleep 27:648-656
2004 Kuo, T. B. J., Shaw, F. Z., Lai, C. J., Lai, C. W. and Yang, C. C. H.* (2004) Changes in sleep patterns in spontaneously hypertensive rats. Sleep 27:406-412
2004 Chen, C. L., Lin, H. H., Orr, W. C., Yang, C. C. H. and Kuo, T. B. J.* (2004) Transfer function analysis of heart rate variability in response to water intake: correlation with gastric myoelectrical activity. Journal of Applied Physiology 96:2226-2230
2004 Lai, H. Y., Yang, C. C. H., Cheng, C. F., Huang, F. Y., Lee, Y., Shyr, M. H. and Kuo, T. B. J.* (2004) Effect of esmolol on positive-pressure ventilation-induced variations of arterial pressure in anaesthetized humans. Clinical Science (Lond) 107:303-308
2004 Kuo, T. B. J., Lai, C. J., Shaw, F. Z., Lai, C. W. and Yang, C. C. H.* (2004) Sleep-related sympathovagal imbalance in SHR. American Journal of Physiology-Heart and Circulatory Physiology 286:H1170-H1176
2003 Yang, C. C. H.* and Kuo, T. B. J. (2003) Dynamic regulation of arterial blood pressure from the brainstem. Tzu Chi Medical Journal 15:1-12
2003 Kuo, T. B. J., Chern, C. M., Yang, C. C. H., Hsu, H. Y., Wong, W. J., Sheng, W. Y. and Hu, H. H.* (2003) Mechanisms underlying phase lag between systemic arterial blood pressure and cerebral blood flow velocity. Cerebrovascular Diseases 16:402-409
2003 Fu, C. H., Yang, C. C. H. and Kuo, T. B. J.* (2003) Effect of angiotensin II eceptor antagonism on cerebral vasomotor reserve in humans. Journal of Cardiovascular Pharmacology 42:714-718
2003 Lee, G. S., Yang, C. C. H. and Kuo, T. B. J.* (2003) Voice low tone to high tone ratio--a new index for nasal airway assessment. Chinese Journal of Physiology 46:123-127
2003 Lai, H. Y., Yang, C. C. H., Huang, F. Y., Lee, Y., Kuo, Y. L. and Kuo, T. B. J.* (2003) Respiratory-related arterial pressure variability as an indicator of graded blood loss: involvement of the autonomic nervous system. Clinical Science (Lond) 105:491-497
2003 Liu, C. C.†, Kuo, T. B. J.† and Yang, C. C. H.* (2003) Effects of estrogen on gender-related autonomic differences in humans. American Journal of Physiology-Heart and Circulatory Physiology 285:H2188-H2193
2003 Yang, C. C. H., Shaw, F. Z., Lai, C. J., Lai, C. W. and Kuo, T. B. J.* (2003) Relationship between electroencephalogram slow-wave magnitude and heart rate variability during sleep in rats. Neuroscience Letters 336:21-24
2002 Wang, J. D., Kuo, T. B. J. and Yang, C. C. H.* (2002) An alternative method to enhance vagal activities and suppress sympathetic activities in humans.
2002 Kuo, T. B. J.* and Yang, C. C. H. (2002) Sexual dimorphism in the complexity of cardiac pacemaker activity. American Journal of Physiology-Heart and Circulatory Physiology 283:H1695-H1702
2002 Yang, C. C. H., Lai, C. W., Lai, H. Y. and Kuo, T. B. J.* (2002) Relationship between electroencephalogram slow-wave magnitude and heart rate variability during sleep in humans. Neuroscience Letters 329:213-216
2000 Su, C. F.*, Kuo, T. B. J., Yang, C. C. H. and Chen, H. I. (2000) Alternation of autonomic nervous functions and cardiovascular hemodynamics in severe head injury. Taiwan Critical Care Medicine 2:129-139
2000 Liu, D. D., Yang, C. C. H., Lee, R. P. and Chen, H. I.* (2000) Opposition of rapid baroreceptor resetting by prostanoids in rabbits. Chinese Journal of Physiology 43:15-21
2000 Yang, C. C. H., Chao, T. C., Kuo, T. B. J., Yin, C. S. and Chen, H. I.* (2000) Preeclamptic pregnancy is associated with increased sympathetic and decreased parasympathetic control of HR. American Journal of Physiology-Heart and Circulatory Physiology 278:H1269-H1273
2000 Kuo, T. B. J. and Yang, C. C. H.* (2000) Altered frequency characteristic of central vasomotor control in SHR. American Journal of Physiology-Heart and Circulatory Physiology 278:H201-H207
2000 Yang, C. C. H. and Kuo, T. B. J.* (2000) Impact of pulse pressure on the respiratory-related arterial pressure variability and its autonomic control in the rat. European Journal of Physiology 439:772-780
1999 Kuo, T. B. J.*, Lin, T., Yang, C. C. H., Li, C. L., Chen, C. F. and Chou, P. (1999) Effect of aging on gender differences in neural control of heart rate. American Journal of Physiology-Heart and Circulatory Physiology 277:H2233-H2239
1999 Yang, C. C. H. and Kuo, T. B. J.* (1999) Assessment of cardiac sympathetic regulation by respiratory-related arterial pressure variability in the rat. Journal of Physiology 515:887-896
1997 Yang, C. C. H., Kuo, T. B. J. and Chan, S. H. H.* (1997) Functional characterization of caudal hypoglossal neurons by spectral patterns of neuronal discharges in the rat. Neuroscience 77:813-827
1997 Kuo, T. B. J., Yang, C. C. H. and Chan, S. H. H.* (1997) Selective activation of vasomotor component of SAP spectrum by nucleus reticularis ventrolateralis in rats. American Journal of Physiology-Heart and Circulatory Physiology 272:H485-H492
1997 Kuo, T. B. J., Yien, H. W., Hseu, S. S., Yang, C. C. H., Lin, Y. Y., Lee, L. C. and Chan, S. H. H.* (1997) Diminished vasomotor component of systemic arterial pressure signals and baroreflex in brain death. American Journal of Physiology-Heart and Circulatory Physiology 273:H1291-H1298
1996 Yang, C. C. H., Chan, S. H. H. and Chan, J. Y. H.* (1996) Physiological> Role of Brain Angiotensin III in Drinking Behavior in the Rat. Journal of Biomedical Science 3:203-210
1996 Kuo, T. B. J., Yang, C. C. H., Chan, J. Y. H., Tsai, H. F. and Chan, S. H. H.* (1996) Further Characterization of Nociception-Related and Arterial Pressure-Related Neuronal Responses in the Nucleus Reticularis Gigantocellularis of the Rat. Journal of Biomedical Science 3:338-347
1996 Yang, C. C. H., Kuo, T. B. J. and Chan, S. H. H.* (1996) Auto- and cross-spectral analysis of cardiovascular fluctuations during pentobarbital anesthesia in the rat. American Journal of Physiology-Heart and Circulatory Physiology 270:H575-H582
1996 Kuo, T. B. J., Yang, C. C. H. and Chan, S. H. H.* (1996) Transfer function analysis of ventilatory influence on systemic arterial pressure in the rat. American Journal of Physiology-Heart and Circulatory Physiology 271:H2108-H2115
1995 Yang, C. C. H., Kuo, T. B. J., Chan, S. H. H., and Chan, J. Y. H.* (1995) Neurobiology of central angiotensin III and dipsogenesis. Biological Signals 4:59-71
1995 Yang, C. C. H., Chan, J. Y. H. and Chan, S. H. H.* (1995) Excitatory innervation of caudal hypoglossal nucleus from nucleus reticularis gigantocellularis in the rat. Neuroscience 65:365-374
1995 Yang, C. C. H., Chan, J. Y. H. and Chan, S. H. H.* (1995) Central effect of angiotensin III on caudal hypoglossal neurons in rats. American Journal of Physiology 268:R1242-1248
1994 Yang, C. C. H., Chan, J. Y. H., Pan, J. T. and Chan, S. H. H.* (1994) Differential neuronal responses to angiotensin III from the subfornical organ of normotensive and spontaneously hypertensive rats. Brain Research 638:169-174
1993 Yang, C. C. H., Chan, J. Y. H. and Chan, S. H. H.* (1993) Unsustained dipsogenic response to chronic central infusion of angiotensin-III in spontaneously hypertensive rats. Endocrinology 132:405-409
发表日期 专利名称 专利编号 专利国别 着作人
2014/05/10 行为模式分析方法 I437458 中华民国
2014/03/10 具无线传输之资料缓冲装置 I432070 中华民国
2012/12/10 Sleep analysis system and method for analyzing sleep thereof. US Patent 8,292,819 B2 美国
2011/02/10 项鍊型心电及体温讯号侦测器 I337536 中华民国
2010/08/10 Earphone sensor system for measuring electrocardiogram signals 7,769,435 B2 美国
2010/03/10 太阳眼镜型瞌睡防止器 I321227 中华民国
2010/03/10 Miniature wireless apparatus for collecting physiological signals 7,672,714 B2 美国
2009/11/10 耳机传感式心电讯号量测系统 I316401 中华民国
2009/08/10 微型无线心电讯号收集装置 I313593 中华民国
2009/07/10 贴片式无线微生理讯号收集装置 I31190 中华民国
2007/10/10 Methods and Apparatus for Analyzing Heart Rate Variability 7,277,746 美国
2006/09/10 脉冲间距至电压转换器及其转换方法 261415 中华民国
2006/08/10 脉冲间距至电压转换器及其转换方法 ZL03143197.6 中国
2006/07/10 阴阳虚实之侦测方法及其装置 ZL03109155.5 中国
2006/05/10 多频道之脉冲间距至电压转换器及转换方法 I254504 中华民国
2006/01/10 Pulse interval to voltage converter and conversion method thereof 6,989,693 美国
2004/12/10 心率变异性分析方法及装置 225394 中华民国
2004/04/10 阴阳虚实之侦测方法及其装置 198840 中华民国