林 惠菁
基础神经研究团队
姓名 林 惠菁
电子邮件 hclin7@ym.edu.tw
联络电话 02-2826-7944
POSITION TITLE/AFFILIATIONS 2019- 国立阳明交通大学 生理学科暨生理学研究所 教授
2016-2019 国立阳明大学 生理学科暨生理学研究所 副教授
国立阳明大学生理学科暨生理学研究所助理教授(2011-2016)


国立成功大学药理所博士后研究员(2008-2011)

法国马赛国家卫生暨医学研究院(INSERM)访问博士后研究员(2011)

美国德州贝勒医学中心小儿研究部门访问博士后研究员(2010)

基隆长庚药剂部(2000-2003)
EDUCATION/TRAINING 国立成功大学基础医学所博士(2008)

国立成功大学药理所硕士(2000)

台北医学大学药学系药学士(1998)
职称 教授
研究专长 Brain function and emotional processes in neurological and psychiatric diseases. Electrophysiology
研究概况 1.自闭症是一种神经发育性的疾病,主要病征为社交能力障碍与沟通能力的缺乏,且常出现反复行为与过度焦虑反应。因此运用表现类似自闭症行为之齧齿类动物模型来探讨自闭症相关大脑异常是一种具挑战性但可能成果丰硕的方法。我们研究主要探讨自闭症动物其大脑神经细胞突触兴奋性和抑制性间平衡改变的机制,并寻找药物改善自闭症所导致之神经与行为异常。

2.现今因社经环境压力导致人类精神疾患人口日益增多。我们研究主题着重于探讨精神疾患所引起大脑功能改变的因素,并寻找调控情绪反应的关键蛋白。研究策略结合神经药物、分子生物学、动物行为模式和神经电生理技术,剖析精神创伤或生理性脑血管疾病造成忧郁,焦虑情绪障碍表现的神经生理机制。

3. 利用非药物治疗像脑部深层电刺激方式,改善神经发育性疾病或精神相关疾病,并探讨其神经回路之作用机制,其优点为减少药物治疗的使用剂量以及使用频率,更可降低药物所导致的副作用,开发临床上除药物使用之外的崭新治疗策略。
年度 论文名称
2018 Wu HF, Chen YJ, Chu MC, Hsu YT, Lu TY, Chen IT, Chen PS, Lin HC *. Deep Brain Stimulation Modified Autism-like Deficits via the Serotonin System in a Valproic Acid-Induced Rat Model. International Journal of Molecular Sciences. 2018 Sep; 19(9) pii: E2840
2018 Kuo CJ, Huang CC, Chou SY, Lo YC, Kao TJ, Huang NK, Lin C, Lin HC, Lin HC*, Lee YC*. Potential therapeutic effect of curcumin, a natural mTOR inhibitor, in tuberous sclerosis complex. Phytomedicine. 2018 Sep. (Accepted) *co-corresponding authors.
2018 Lee YC, Huang WC, Lin JH, Kao TJ, Lin HC, Lee KH, Lin HC, Shen CJ, Chang WC, Huang CC. Znf179 E3 ligase-mediated TDP-43 polyubiquitination is involved in TDP-43- ubiquitinated inclusions (UBI) (+)-related neurodegenerative pathology. Journal of Biomedical Science. 2018 Nov 8;25(1):76.
2018 Lee HT, Lee KI, Lin HC, Lee TS. Genetic Deletion of Soluble Epoxide Hydroxylase Causes Anxiety-Like Behaviors in Mice. 2018 Jul Molecular Neurobiology.
2018 Wu HF, Chen PS, Hsu YT, Lee CW, Wang TF, Chen YJ, Lin HC*. D-Cycloserine ameliorates autism-like deficits by removing GluA2-containing AMPA receptors in a valproic acid-induced rat model. Molecular Neurobiology. 2018 Jun;55(6):4811-4824.
2018 Chang LH, Lin HC, Huang SS, Chen IC, Chu KW, Chih CL, Liang YW, Lee YC, Chen YY, Lee YH, Lee IH. Blockade of soluble epoxide hydrolase attenuates post-ischemic neuronal hyperexcitation and confers resilience against stroke with TrkB activation. Scientific Reports . 2018 Jan 8;8(1):118.
2018 Yeh CH, Hsieh LP, Lin MC, Wei TS, Lin HC, Chang CC, Hsing CH. Dexmedetomidine reduces lipopolysaccharide induced neuroinflammation, sickness behavior, and anhedonia. PLoS One 2018, Jan;13 (1):e0191070.
2017 Wu HF, Chen PS, Chen YJ, Lee CW, Chen IT, Lin HC*. Alleviation of N-methyl-D-aspartate Receptor-Dependent Long-term depression via regulation of the Glycogen Synthase Kinase-3β pathway in the amygdala of a valproic acid-induced animal model of autism. Molecular Neurobiology 2017 Sep; 54(7), 5264-5276.
2017 Wu HF#, Chen YJ#, Wu SZ, Lee CW, Chen IT, Lee YC, Huang CC, Hsing CH, Tang CW, Lin HC*. Soluble epoxide hydrolase inhibitor and 14, 15-epoxyeicosatrienoic acid-facilitated long-term potentiation through cAMP and CaMKII in the hippocampus. Neural Plasticity. 2017Jul. #equal contribution.
2017 Huang HJ, Wang YT, Lin HC, Lee YH, Lin AM. Soluble Epoxide Hydrolase Inhibition Attenuates MPTP-Induced Neurotoxicity in the Nigrostriatal Dopaminergic System: Involvement of α-Synuclein Aggregation and ER Stress. Molecular Neurobiology. 2017Aug. DOI: 10.1007/s12035-017-0726-9.
2017 Wang CF, Yang SH, Lin SH, Chen PC, Lo YC, Pan HC, Lai HY, Liao LD, Lin HC, Chen HY, Huang WC, Huang WJ, Chen YY. A proof-of-principle simulation for closed-loop control based on preexisting experimental thalamic DBS-enhanced instrumental learning. Brain Stimulation 2017 Feb. pii: S1935-861X(17) 30611-3.
2017 Lee KI, Lin HC, Lee HT, Tsai FC, Lee TS. Loss of transient receptor potential ankyrin 1 channel deregulates emotional, social, cognitive, learning and memory development. Molecular Neurobiology 2017 Jul;54(5):3606-3617.
2017 Wang YT, Lin HC, Zhao WZ, Huang HJ, Lo YL, Wang HT, Lin AM. Acrolein acts as a neurotoxin in the nigrostriatal dopaminergic system of rat: involvement of α-synuclein aggregation and programmed cell death. Scientific Reports . 2017 Apr 12;7:45741.
2017 Tsou JH, Yang YC, Pao PC, Lin HC, Huang NK, Lin ST, Hsu KS, Yeh CM, Lee KH, Kuo CJ, Yang DM, Lin JH, Chang WC, Lee YC. Important roles of Ring Finger Protein 112 in embryonic vascular development and brain function. Molecular Neurobiology. 2017 Apr;54(3):2286-2300.
2016 Li CT, Lu CF, Lin HC, Huang YZ, Juan CH, Su TP, Bai YM, Chen MH, Lin WC. Cortical inhibitory and excitatory function in drug-naive generalized anxiety disorder. Brain Stimulation 2016 Dec. pii: S1935-861X(16) 30389-8.
2016 Yang SH, Chen YY, Lin SH, Liao LD, Lu HS, Wang CF, Chen PC, Lo YC, Phan TD, Chao HY, Lin HC, Lai HY, Huang WC. A sliced inverse regression (SIR) decoding the forelimb movement from neuronal spikes in the rat motor cortex. Frontiers in Neuroscience.2016 Nov. doi: 10.3389/fnins.2016.00556
2016 Chang CF, Lee YH, Lee KH, Lin HC, Chen CL, Shen CK, Huang CC. Therapeutic effect of berberine on TDP-43-related pathogenesis in FTLD and ALS. Journal of Biomedical Science 2016 Oct; 23:72.
2016 Lee KI, Lee HT, Lin HC, Tasy HJ, Tsai FC, Shyue SK, Lee TS. Role of transient receptor potential Ankyrin 1 channels in Alzheimer’s disease. Journal of Neuroinflammation 2016 Apr; 13(1): 92. doi: 10.1186/s12974-016-0557-z.
2016 Lee KI, Chiang CW, Lin HC, Zhao JF, Li CT, Shyue SK, Lee TS. Maternal exposure to di-(2-ethylhexyl) phthalate exposure deregulates blood pressure, adiposity, cholesterol metabolism and social interaction in mouse offspring. Archives of Toxicology 2016 May; 90(5): 1211-1224.
2015 Lin HC#, Pan HC#, Lin SH, Lo YC, Shen Elise TH, Liao LD, Liao PH, Chien YW, Liao KD, Jaw FS, Chu KW, Lai HY, Chen YY. Central thalamic deep-brain stimulation alters striatal–thalamic connectivity in cognitive neural behavior. #equal contribution. Frontiers in Neural Circuits 2016 Jan 13; 9:87. doi: 10.3389/fncir.2015.00087. #equal contribution.
2015 Wu HF, Yen HJ, Huang CC, Lee YC,Wu SZ , Lee TS, Lin HC*, Soluble epoxide hydrolase inhibitor enhances synaptic neurotransmission and plasticity in mouse prefrontal cortex. Journal of Biomedical Science 2015 Oct; 22:94. doi: 10.1186/s12929-015-0202-7. SCI.
2015 Lin HC#, Li CT#, David Tan TW, Cheng CW, Chou TK, Kong FL, Yu TH, Huang WS, Su DP, Liu RS, Skye Yeh HH. Non-linear alteration of serotonin transport availability in posttraumatic stress disorder measured with 4- [18F]ADAM positron emission tomography. Current Molecular Imaging 2015; 4: 57-64. #equal contribution
2015 Wang CY, Lin HC#, Song YP#, Hsu YT#, Lin SY, Hsu PC, Lin CH, Hung CC, Hsu MC, Kuo YM, Lee YJ, Hsu CY, Lee YH. 2015. Protein kinase C dependent growth-associated protein 43 phosphorylation regulates gephyrin aggregation at developing GABAergic synapses. Molecular and Cellular Biology 2015 May; 35(10):1712-1726. #equal contribution.
2014 Chen YW, Lin HC,Ng MC, Hsiao YH, Wang CC, Gean PW, Chen PS. Activation of mGluR2/3 underlies the effects of N-acetylcystein on amygdala associated autism-like phenotypes in a valproate-induced rat model of autism. Frontiers in Behavioral Neuroscience. 2014 Jun; 8: 219
2013 Wang CC#, Lin HC#, Chan YH, Gean PW, Yang YK, Chen PS. (2013). 5-HT1A-receptor agonist modified amygdala activity and amygdala-associated social behavior in a valproate-induced rat autism model. International Journal of Neuropsychopharmacology 2013 Oct; 16(9):2027-2039. # equal contribution.
2013 Lin HC, Gean PW, Wang CC, Chan YH, Chen PS. The Amygdala Excitatory/Inhibitory Balance in a Valproate-induced Rat Autism Model. PLoS One 2013, Jan; 8(1):e55248.
2011 Lin HC, Tseng YC, Mao S, Gean PW. GABAA receptor endocytosis in the basolateral amygdala is critical to the reinstatement of fear memory measured with fear-potentiated startle. The Journal of Neuroscience 2011 Tun; 31(24):8851-8861.
2010 Lin HC, Mao SC, Su CL, Gean PW. Alterations of excitatory transmission in the lateral amygdala during expression and extinction of fear memory. International Journal of Neuropsychopharmacology 2010 Apr; 13(3):335-345.
2009 Lin HC, Mao SC, Su CL, Gean PW. The role of prefrontal cortex CB1 receptors in the modulation of fear memory. Cereb Cortex 2009 Jan;19(1):165-175.
2009 Lin HC, Mao SC, Gean PW. Block of GABAA receptor insertion in the amygdala impairs extinction of conditioned fear. Biological Psychiatry 2009 Oct; 66(7) 665-673.
2009 Mao SC, Lin HC, Gean PW. Augmentation of fear extinction by infusion of glycine transporter blockers into the amygdala. Molecular Pharmacology 2009 Aug; 76(2):369-378.
2008 Lin HC, Mao SC, Chen PS, Gean PW. Chronic cannabinoid administration in vivo compromises extinction of fear memory. Learning & Memory 2008 Dec; 15(12):876-884.
2008 Mao SC, Lin HC, Gean PW. Augmentation of Fear Extinction by D-Cycloserine is Blocked by Proteasome Inhibitors. Neuropsychopharmacology 2008 Dec; 33(13):3085-3095.
2006 Lin HC, Mao SC, and Gean PW. Effects of intra-amygdala infusion of CB1 receptor agonists on the reconsolidation of fear-potentiated startle. Learning & Memory 2006 May; 13(3): 316-321.
2006 Yeh SH, Mao SC,Lin HC, Gean PW. Synaptic expression of glutamate receptor after encoding of fear memory in the rat amygdala. Molecular Pharmacology 2006 Jan; 69(1): 299-308.
2000 Lin HC, Wang SJ, Luo MZ, Gean PW. Activation of group II metabotropic glutamate receptors induces long-term depression of synaptic transmission in the rat amygdala. The Journal of Neuroscience. 2000 Dec; 20(24): 9017–9024.