Yi-Hsuan Lee
Basic Neuroscience
Name Yi-Hsuan Lee
Email yhlee3@ym.edu.tw
Office Tel No. 02-2826-7067
POSITION TITLE/AFFILIATIONS 國立陽明大學 特聘教授 (2017-2019)

國立陽明大學 教授 (2010-迄今)

臺北醫學大學醫學系生理學科 教授 (2003-2010)

臺北醫學大學醫學系生理學科 副教授 (1995-2003)

長庚紀念醫院整形外科 副研究員 (1994-1995)
EDUCATION/TRAINING 美國堪薩斯大學生理暨細胞生物系 博士 (1993)

台灣大學農業化學系 學士 (1988)
Research Molecular and cellular neurobiology in neurotraum and neurodegenerative diseases.
研究概況 1.探討多重環境壓力之交互作用影響大腦發育與神經退化之分子機制。多重環境壓力包括壓力荷爾蒙糖皮質素及其受體 (glucocorticoid receptor)、環境荷爾蒙及其受體芳香烴受體(aryl hydrocarbon receptor)、及低氧及低氧誘發因子(hypoxia-inducible factors)。
2.探討神經生長蛋白GAP43在神經系統發育及神經損傷後復原過程中，對突觸塑性及神經膠細胞活性之影響。
3.探討中樞神經白質損傷之神經保護機制。
Year Paper Title
2018 Huang HJ, Wang YT, Lin HC, Lee YH*, Lin AM*. Soluble Epoxide Hydrolase Inhibition Attenuates MPTP-Induced Neurotoxicity in the Nigrostriatal Dopaminergic System: Involvement of α-Synuclein Aggregation and ER Stress. MOLECULAR NEUROBIOLOGY. 2018; 55(1):138-144.
2017 Huang SL, Chang CW, Lee YH, Yang FY*. Protective Effect of Low-Intensity Pulsed Ultrasound on Memory Impairment and Brain Damage in a Rat Model of Vascular Dementia. RADIOLOGY. 2017; 282(1):113-122.
2017 Chou CC, Modi JP, Wang CY, Hsu PC, Lee YH*, Huang KF, Wang AH*, Nan C, Huang X, Prentice H, Wei J, Wu JY*. Activation of Brain L-glutamate Decarboxylase 65 Isoform (GAD65) by Phosphorylation at Threonine 95 (T95). MOLECULAR NEUROBIOLOGY, 2017; 54(2):866-873.
2016 Hung CC, Lin CH, Chang H, Wang CY, Lin SH, Hsu PC, Sun YY, Lin TN, Shie FS, Kao LS, Chou CM, Lee YH*. Astrocytic GAP43 induced by the TLR4/NF-κB/STAT3 axis attenuates astrogliosis-mediated microglial activation and neurotoxicity. JOURNAL OF NEUROSCIENCE, 2016; 36(6):2027-43.
2015 Wang CY, Lin HC, Song YP, Hsu YT, Lin SY, Hsu PC, Lin CH, Hung CC, Hsu MC, Kuo YM, Lee YJ, Hsu CY, Lee YH*. PKC-dependent GAP43 phosphorylation regulates gephyrin aggregation at developing GABAergic synapses. MOLECULAR AND CELLULAR BIOLOGY 2015; 35(10): 1712–1726.
2015 Lee YH*, Lin CH, Hsu PC, Sun YY, Huang YJ, Zhuo JH, Wang CY, Gan YL, Hung CC, Kuan CY, Shie FS*. Aryl hydrocarbon receptor mediates both proinflammatory and antiinflammatory effects in lipopolysaccharide-activated microglia. GLIA 2015; 63(7):1138-1154.
2013 Sun YY, Lin SH, Lin HC, Hung CC, Wang CY, Lin YC, Lien CC, Kuan CY, Lee YH*. Cell type-specific dependency on the PI3K/Akt signaling pathway for the endogenous Epo and VEGF induction by baicalein in neurons versus astrocytes.PLoS One 2013; 8(7):e69019.
2011 Lin MS, Hung KS, Chiu WT, Sun YY, Tsai SH, Lin JW,Lee YH*. Curcumin enhances neuronal survival in N-methyl-D-aspartic acid toxicity by inducing RANTES expression in astrocytes via PI-3K and MAPK signaling pathways. PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATYR 2011;35(4):931-938.
2011 Lin MS, Sun YY, Chiu WT, Chang CY, Hung CC, Shie FS, Tsai SH, Lin JW, Hung KS, Lee YH*. Curcumin attenuates the expression and secretion of RANTES following spinal cord injury in vivo and lipopolysaccharide-induced astrocyte reactivation in vitro. JOURNAL OF NEUROTRAUMA 2011;28:1259-1269.
2010 Sun YY, Wang CY, Hsu MF, Juan SH, Chang CY, Chou CM, Yang LY, Hung KS, Xu J, Lee YH*, Hsu CY*. Glucocorticoid protection of oligodendrocytes against excitotoxin involving hypoxia-inducible factor-1α in a cell type-specific manner. JOURNAL OF NEUROSCIENCE 2010;30(28):9621-9630.
2010 Chang CY, Lee YH, Leu SJ, Wang CY, Wei CP, Hung KS, Pai MH, Tsai MD, Wu CH*. CCL18/PARC expression in the central nervous system with special reference to traumatic brain injuries and neoplastic disorders. NEUROSCIENCE 2010;165:1233-1243.
2009 Lin CH, Chen CC, Chou CM, Wang CY, Hung CC, Chen JY, Chang HW, Chen YC, Yeh GC, Lee YH*. Knockdown of the aryl hydrocarbon receptor attenuates excitotoxicity and enhances NMDA-induced BDNF expression in cortical neurons. JOURNAL OF NEUROCHEMISTRY 2009;111:777-789.
2008 Lin CH, Juan SH, Wang CY, Sun YY, Chou CM, Chang SF, Hu SY, Lee WS, Lee YH*. Neuronal activity enhances aryl hydrocarbon receptor-mediated gene expression and dioxin neurotoxicity in cortical neurons. JOURNAL OF NEUROCHEMISTRY 2008;104:1415-1429.
2008 Liu WL, Lee YH, Tsai SY, Hsu CY, Sun YY, Yang LY, Tsai SH, Yang WCV*. Methylprednisolone inhibits the expression of glial fibrillary acidic protein and chondroitin sulfate proteoglycans in reactivated astrocytes. GLIA 2008;56:1390-1400
2007 Tsai SY, Yang LY, Wu CH, Chang SF, Hsu CY, Wei CP, Leu SJ, Liaw J, Lee YH*, Tsai MD.. Injury Induced JAK/PKC-Dependent Phosphorylation of GAP-43 and STAT3 for Neurite Growth in Dorsal Root Ganglion. JOURNAL OF NEUROSCIENCE RESEARCH 2007;85:321-331.
2005 Chang SF, Sun YY, Yang LY, Tsai SY, Hu SY, Lee WS, Lee YH*. Bcl-2 gene family expression in the brain of rat offspring after gestational and lactational dioxin exposure. ANNALS OF THE NEW YORK ACADEMY OF SCIENCES 2005;1042:471-480.
2003 Lee HH, Yang LL, Wang CC, Hu SY, Chang SF, Lee YH*. Differential effects of natural polyphenols on neuronal survival in primary cultured central neurons against glutamate- and glucose deprivation-induced neuronal death. BRAIN RESEARCH. 2003; 986(1-2):103-13.
2000 Lee YH*, Fang KM, Yang CM, Hwang HM, Chiu CT, Tsai W. Kainic acid-induced neurotrophic activities in developing cortical neurons. JOURNAL OF NEUROCHEMISTRY. 2000; 74(6):2401-11.
Year Project Title Participator Job Title Period Unit
2018
2018
2018
2018
Publish Date Patent Title Patent Number Patent Country Authors
2012/07/27 US 8,211,695.
2013/07/27 發明第I401434號