David M. Niddam
Clinical Neuroscience
Name David M. Niddam
Email niddam@ym.edu.tw
Office Tel No. 02-2826-7389
POSITION TITLE/AFFILIATIONS 2013-迄今 國立陽明大學腦科所　兼任副教授
2008-迄今 國立陽明大學腦科學中心　副研究員
2004-迄今 台北榮民總醫院　教學研究部　整合性腦功能研究小組　副研究員
2010-2013 國立陽明大學腦科所　兼任助理教授
2003-2008 國立陽明大學腦科學中心　助理研究員
2002-2003 國立陽明大學神經科學研究中心　博士後研究員
EDUCATION/TRAINING 2002 丹麥奧爾堡大學感覺與運動研究中心　生物醫學科學及神經科學之工程學博士學位
2001 台北榮總整合性腦功能研究小組客座研究人員
1998 丹麥哥本哈根大學生物物理及物理　科學碩士
1996 丹麥哥本哈根大學生物物理及物理　科學學士
Research Brain imaging, Experimental and clinical pain, Pain modulation
研究概況 The main focus of my work is on central processing of acute and chronic pain. Recent research is focused on the mechanisms underlying alleviation of clinical ongoing pain in response to modulatory techniques such as peripheral and central stimulation and pharmacological intervention. A variety of brain imaging techniques, pain modalities, and tissue systems are being explored. Optimized stimulation protocols are being developed for intractable headaches using transcranial DC stimulation. The central manifestations of the pain modulatory effects are being investigated with newly developed techniques such as 2D and 3D glutamatergic MR spectroscopic imaging and functional brain connectivity. All research is performed in close collaboration with clinicians and MR physicists.
Year Paper Title
2014 Niddam DM, Tsai SY, Lin YR. Statistical mapping of metabolites in the medial wall of the brain: A proton echo planar spectroscopic imaging study. Hum Brain Mapp. 2014 Oct 23
2014 Lin CS, Hsieh JC, Yeh TC, Niddam DM. Predictability-mediated pain modulation in context of multiple cues: An event-related fMRI study. Neuropsychologia. 2014 Sep 26;64C:85-91
2013 Lin CS, Hsieh JC, Yeh TC, Lee SY, Niddam DM. Functional dissociation within insular cortex: the effect of pre-stimulus anxiety on pain. Brain Res. 2013; 1493:40-7
2013 Lin CS, Niddam DM, Hsu ML, Hsieh JC. Pain catastrophizing is associated with dental pain in a stressful context. J Dental Res. 2013; 92(2): 130-5. (Equal contribution to first authorship.)
2013 Tu CH, Niddam DM, Yeh TC, Lirng JF, Cheng CM, Chou CC, Chao HT, Hsieh JC. Menstrual pain is associated with rapid structural alterations in the brain. Pain. 2013 May 18
2012 Tsai SY, Lin YR, Wang WC, Niddam DM. Short- and long-term quantitation reproducibility of brain metabolites in the medial wall using proton echo planar spectroscopic imaging. NeuroImage 2012; Nov 15; 63(3): 1020-1029
2011 Niddam DM, Tsai SY, Lu CL, Ko CW, Hsieh JC. Reduced hippocampal glutamate-glutamine levels in irritable bowel syndrome: preliminary findings using magnetic resonance spectroscopy. Am. J. Gastro. 2011, 106(8):1503-11.
2010 Tu CH, Niddam DM, Chao HT, Chen LF, Chen YS, Wu YT, Yeh TC, Lirng JF, Hsieh JC. Brain morphological changes associated with cyclic menstrual pain. Pain. 2010 Sep;150(3):462-468.