Cheryl C.H. Yang
Basic Neuroscience
Name Cheryl C.H. Yang
Email cchyang@ym.edu.tw
Office Tel No. (02)2826-7058
POSITION TITLE/AFFILIATIONS 2006/08- 教授 國立陽明大學 腦科學研究所
2007/06- 主任 國立陽明大學 睡眠研究中心
2005/08-2006/07 教授兼所長 慈濟大學 整合生理暨臨床科學研究所
2000/08-2005/07 副教授兼科主任 慈濟大學 生理學科
2001/06-2006-07 教授 慈濟大學 生理學科 (教字第11422號)
1997/08-2001/05 副教授 慈濟醫學暨人文社會學院 生理學科
1996/08-1997/07 助理教授 慈濟醫學暨人文社會學院 生理學科 (副字第23740號)
EDUCATION/TRAINING 1991/09-1995/06 博士 陽明大學 生理學研究所
畢業論文： Neurobiologic Role of Hypoglossal Nucleus in Central AngiotensinIII-Induced Drinking Response in Rats
1989/09-1991/06 碩士 陽明醫學院 藥理學研究所
畢業論文：Differential Drinking Responses to Chronic Central Infusion of Angiotensin III in Spontaneously Hypertensive and Normotensive Rats
1984/09-1988/06 學士 私立台北醫學院 藥學系
Research Neural Physiology, Pharmacology
研究概況 一、動脈壓變異性分析與應用 (呼吸影響波動，BHF；血管運動影響波動，BLF)

BHF：動脈壓呼吸波動與自律神經功能之關係，長久以來一直為學者所忽視。本研究室1999年論文1 首次證明動脈壓呼吸相關律動可做為評估大鼠之心臟交感神經活性。另兩篇論文更詳細探討此頻率成份來源及其機轉2, 3。另外，動物失血時會引發此波動功率之上升具專一性，研究結果發現失血所引發之現象與自律神經之β-交感神經活性具極密切之相關4；由於動脈壓訊號於醫院中容易取得，故於人類研究亦證明此波動與β-交感神經活性有關5，將來更有非侵體性測量技術發展之可能。故此部分論文可提供一項發展潛力極高之心臟交感神經功能或失血現象評估方法。

BLF：本研究室曾參與動脈壓低頻律動之臨床應用及其來源之探討，已知其與交感神經對血管調控有關。高血壓疾病一直威脅人類健康且名列十大死因之一，然至今對它的瞭解仍然不多。事實上血壓的調節乃一動態之平衡，綜觀多數研究皆以靜態方式探討，恐失去許多重要訊息。吾人嘗試以動態角度觀察SHR與正常血壓對照鼠 (WKY) 之差異並研究其延腦動態控壓能力 (或謂血管對神經之反應性) 之差異，吾人首度證明SHR的延腦動態控壓能力強於WKY鼠，並有較快之反應速率，更詳細洞悉高血壓形成原因6。並進一步探討交感神經於其間扮演之角色。另本研究室成功開發自由活動大鼠之動脈壓變異性分析研究模式7，於此動物模式亦得到類似之研究結果與結論。但此現象僅獨特出現於睡眠時期，更指出睡眠研究之重要性，詳見第三部份的敘述。

二、心率變異性 (HRV) 之分析與應用

由於訊號取得較易，心率變異性之研究開發較早。本研究室以自製之心電放大器 (郭教授設計) 及配合撰寫分析程式 (郭教授撰寫)，與公衛專家合作將記錄到的台灣南投縣漁池鄉中老年等數千人之資料作分析，完整評估健康人心臟自律神經之功能參數，發現五十歲前男性在休息狀態下之基礎交感神經活性比女性高；相反的，女性之基礎副交感神經活性則比男性高。但此現象於五十歲後男女差別即消失8，推論此現象與女性五十歲左右時停經現象有關；其後與地區衛生所合作，更針對此問題探索同年齡層五十歲左右之男、女自律神經活性差異之謎。確認女性內生性性激素於停經前扮演重要之角色。女性停經後若補充雌激素則可回復至停經前之自律神經功能表現9；之後以自由活動大鼠之研究模式，探討內生性雌激素之角色，也確認雌激素其促進副交感基礎活性之作用10；此方面研究也與傳統醫學醫師合作，發現針灸對停經婦女之自律神經失調具改善效果。有趣的是，針灸亦能一併改善停經後之睡眠問題11；應用到婦產科子顛前症懷孕病人，發現病人有交感活性過度興奮而副交感活性異常降低現象，提供臨床治療一重要訊息12；針炙應用之研究也發現，由於人面臨壓力或各種病徵時，往往增強交感而抑制副交感神經活性；而針刺四神囪穴可有效加強副交感且抑制交感神經活性，可提供臨床治療上方便且少傷害之重要方法13。與腸胃科合作開發評估人類及大鼠，胃之自律神經功能的新方法14-16；與神經內科確認中風對自律神經功能的影響17 與神經外科探索癲癇病人的自律神經功能變化 18-20；與泌尿科探索心臟自律神經系統於男性性功能障礙之角色21；與精神科及藥師探索人類及大鼠之精神疾病、用藥情況及治療對心臟自律神經功能之影響22-31；與精神科探索實習醫師之壓力問題32-34。另也瞭解美沙冬對毒物成癮的替代療法對心臟自律神經功能之影響26, 28。另人格特質與自律神經功能也有一定關係35,36。另外，利用控制呼吸頻率與吸氣及呼氣時間比例，來探究各項HRV參數及感壓反射靈敏度的變化及影響，詳細了解HRV及感壓反射靈敏度設計實驗時，呼吸影響的重要性37-40。

三、人與大鼠之睡醒與自律神經相關研究

吾人現擔任陽明大學睡眠研究中心主任，積極與基礎與臨床研究者合作，利用過去已確立的人及自由活動大鼠之研究模式41, 42，而成為本研究室近年的研究主軸。過去本研究室可量測到人及大鼠之心電訊號，並詳細觀察睡眠中自律神經之變化43, 44，也詳細探討其中自律神經功能與睡醒之因果關係45，並進一步解答自律神經功能於睡及醒調控之正常生理及可能病理機轉。研究發現有 (1) 跟傳統醫學合作發現停經婦女的睡眠問題與自律神經調控實具高度關連，並可透過針灸適度緩解自律神經之異常，亦能有效改變睡眠品質11。(2) 護理人員值班 (長期值夜或輪班) 的睡眠自律神經功能變化46-48，提醒值班設計的重要性。(3) 探討SHR之睡眠與自律神經功能變化，SHR睡眠結構與WKY具明顯差異性，並具明顯睡眠片斷現像49-51，另特別於睡眠時才出現循環自律神經調控缺陷51。Circulation期刊還特別為我們的研究設計及重要發現寫評論 52。也找出SHR之睡眠異常可能與交感神經1-adrenergic system過度興奮有關53。近年我們更建立完全的無線大鼠模式，除在測量時動物能更自由、更無壓力外，亦使記錄時間可以延長並有機會 (4) 瞭解超過24小時之正常生理律動54及改變光照造成之影響 (結果整理中)，可以詳細在控制環境下探討所謂時差等因素對人的可能影響；(5) 本實驗室更自製遙控電刺激模式，電興奮血管運動中樞 (rostro ventral lateral medulla, RVLM)，證明正常血壓鼠可因RVLM之刺激使睡眠模式轉變為類似SHR之片斷式睡眠。上述之研究結果可間接解答SHR可能是因為RVLM 過度興奮造成睡眠片斷現像55，電刺激RVLM造成醒覺的發現，期刊也特別為我們的研究及發現寫評論 56 (6) 利用大鼠模式，仔細了解人類一日於夜間睡眠時血壓下降 (blood pressure dipping, BP dipping) 在正常生理之角色，其可能之機轉。確認其中醒睡於BP dipping之比重佔超過90%，而日夜節律則僅佔不到10% 的影響，進一步探討BP nondipping之可能病理原因57；另，已知睡眠後期是全天中最高好發心循環疾病的時間，我們也確立了與人類相似之大鼠研究模式，了解此期間可能與睡眠後期之睡眠結構不穩定及自律神經系統偏向交感神經活性有關53；(7) 另，利用人類及大鼠之動物模式分別進行研究冬季好發心循環疾病的可能機轉，實驗設計特別為台灣冬季低溫模式，且已確認許多可能機轉58；(8) 除探索好發心循環疾病的問題，我們也試著了解運動降血壓之機轉，希望提出更好的預防及治療高血壓模式 (大鼠及人都已有結果，一篇投稿中，一篇撰寫中)。目前正積極探討上述各因子於高血壓之特異表現。(9) 小鼠的研究模式已完成研究技術之建立，目前論文正投稿中。此方面更開啟與分子生物領域研究合作之可能。(10) 另我們也發現自覺入睡困難者其白天副交感神經活性較弱及交感神經活性偏高，入睡過程中腦波高頻波活性也偏高於睡眠品質良好者，顯示入睡困難問題與皮質過度興奮有關；而慢速 (0.1 Hz) 定量呼吸訓練，可有效降心率及調升整體自律神經功能，同時並能有效改善客觀睡眠品質，特別是縮短入睡時間以及提升睡眠效度59，本論文也提出入睡困難失眠者有效的非藥物治療方法，此議題也將是本實驗室未來探索睡眠問題的主軸。(11) 我們與床枕公司合作探討以躺床之肌力測試來選床，發現短期間睡在選出較適的床上，可有效改善循環神經調控及感壓反射靈敏度60，突顯睡眠時床墊選擇的重要性。

除了睡眠研究，我們也將視野跨到人非睡眠時期之白天自律神經功能變化，並看午睡對自律神經功能的影響及其可能生理意義 (論文投稿中)。近年更將研究技術方向拓展到雲端人性化之睡眠 (以研究室自行開發之活動計量測) 及心循環系統等功能測量，使睡眠及各式生理參數的記錄更生活化更普及化。不用等到研究成果出來，受試者只要參與監測生理訊號即對自己的身體保健就能多一層了解及關心，軟硬體架構幾乎完成，目前正積極進行各式人體試驗。

四、正在運動中大鼠之腦波與自律神經研究

　　因本研究室近幾年已建立自由活動大鼠模式之腦波、肌電波、血壓及心電波等多訊號記錄，我們將探索範圍延伸至活動狀態下，特別探索正在運動中大鼠的腦波、肌電波及心電波。我們已成功記錄大鼠進行等速跑步機運動時的腦波及心電訊號，發現在運動過程中大腦枕葉theta頻帶成份會增加，而已知此頻帶可能與認知能力有關61, 62。由於這是之前許多運動研究上較少能做到的記錄及各式控制，所以在這方面研究上仍擁有許多優勢。並記錄大鼠海馬迴之腦波發現，跑步運動可依照theta波成分作分期，並藉此探討感覺運動整合的過程。另，亦記錄自由活動之滾輪運動大鼠，探討速度與theta波之關係63。最後藉由兩種運動模式探討自願運動與被動運動之差異，發現兩種運動雖速度及活動力都不同。經過分析比較後，我們認為theta波的高頻成分可能與心理壓力有關64。此外我們也進一步探討老化對運動過程中腦波的影響，發現老化會減低運動對腦波的反應，此現象僅於運動中才觀察的到65。再者，我們亦觀察老化對運動過程中大鼠心率變異性之影響，結果暗示老化為造成心臟調控能力簡化之因素之一，是值得注意的，此部份正投稿中。另透過記錄在水管內移動之大鼠生理訊號，以釐清視覺及身體活動對theta波產生之貢獻66。過去我們確認SHR的運動訓練確實可減緩隨年齡增加的高血壓及睡眠問題 (投稿中)，今年擬更進一步了解SHR的運動訓練是否也可防止因血壓上升引發的學習記憶能力缺陷的問題，其中自律神經系統、睡眠及腦波成份等各生理參數是否亦扮演重要角色。
Year Paper Title
2016 Li, J. Y., Kuo, T. B. J., Yang, C. C. H.* (2016) Aged rats show the dominant modulation on lower frequency of hippocampal theta rhythm during running. Experimental Gerontology 83:63-70
2016 Kuo, T. B. J. †, Lai, C. T. , Chen, C. Y. †, Yang, Y. C., Yang, C. C. H.* (2016) The high-frequency component of heart rate variability during extended wakefulness is closely associated with the depth of the ensuing sleep in C57BL6 mice. Neuroscience 330: 257-66
2016 Lin, Y. C., Lin, Y. H., Lo, M Z., Peng, C. K., Huang, N. E., Yang, C. C. H., Kuo, T. B. J.* (2016) Novel application of multi dynamic trend analysis as a sensitive tool for detecting the effects of aging and congestive heart failure on heart rate variability. Chaos 26:023109
2016 Hong C. H. †, Kuo, T. B. J. †, Huang B. C., Lin Y. C., Kuo K. L., Chern C. M., Yang, C. C. H.* (2016) Cold exposure can induce an exaggerated early-morning blood pressure surge in young prehypertensives. PLoS One.11(2):e0150136
2016 Kuo, T. B. J. †, Chen C. Y. †, Hsu, Y. C., Yang, C. C. H.* (2016) EEG beta power and heart rate variability describe the association between cortical and autonomic arousal across sleep. Autonomic Neuroscience: basic and clinical 194:32-7
2016 Kuo, T. B. J. †, Li, J. Y. †, Kuo, H. K., Chern, C. M., Yang, C. C. H.* (2016) Differential changes and interactions of autonomic functioning and sleep architecture before and after 50 years of age. Age 38:5
2015 Huang W. L., Liao S. C., Kuo, T. B. J., Chang, L .R., Chen, Z. T., Chen, I. M., Yang, C. C. H.* (2015) The effects of antidepressants and quetiapine on heart rate variability. Pharmacopsychiatry [Epub ahead of print]
2015 Tsai, H. J. †, Kuo, T. B. J., Lin, Y. C. †, Yang, C. C. H.* (2015) The association between prolonged sleep onset latency and heart rate dynamics among young sleep-onset insomniacs and good sleepers. Psychiatry Research 230:892-898
2015 Lai, C. T., Chen, C. Y., Kuo, T. B. J., Chern, C. H., Yang, C. C. H.* (2015) Sympathetichyperactivity, sleep fragmentation and wake-related blood pressure surge during late-light sleep in spontaneously hypertensive rats. American Journal of Hypertension 29:590-7
2015 Wang, Y. B., Kuo, T. B. J., Lai C.T., Yang, C. C. H.* (2015) Effects of breathing frequency on the heart rate deceleration capacity and heart rate acceleration capacity. European Journal of Applied Physiology 115:2415-2420
2015 Huang W. L., Hwang B. T., Lai C. T., Li J. Y., Kuo, T. B. J., Yang, C. C. H.* (2015) Is heart rate variability related to season of birth? Clinical Cardiology 38:407-412
2015 Lin Y. H., Lin Y. C., Lee Y. H., Lin P. H., Lin S. H., Chang L. R., Tseng H. W., Yen L. Y., Yang, C. C. H., Kuo, T. B. J.* (2015) Time distortion associated with smartphone addiction: identifying smartphone addiction via a mobile application (App) Journal of Psychiatric Research 65:139-145
2015 Tsai, H. J., Kuo, T. B. J., Lee, G.-S., Yang, C. C. H.* (2015) Efficacy of paced breathing for insomnia: enhances vagal activity and improves sleep quality. Psychophysiology 52:388-396
2014 Wang, Y. B., Kuo, T. B. J., Yang, C. C. H.* (2014) A possible explanation for the effects of respiration on heart rate and blood pressure asymmetry. International Journal of Cardiology 174:805-807
2014 Kuo, T. B. J., Hong, C.-H., Hsieh, I.-T., Lee, G.-S., Yang, C. C. H.* (2014) Effects of cold exposure on autonomic changes during the last REM sleep transition and morning blood pressure surge in humans. Sleep Medicine 15:986-997
2014 Li, J.-Y., Kuo, T. B. J., Yen, J.-C., Tsai, S.-C., Yang, C. C. H.* (2014) Voluntary and involuntary running in the rat show different patterns of theta rhythm, physical activity and heart rate. Journal of Neurophysiology 111:2061-2070
2014 Wang, Y. P., Kuo, T. B. J., Yang, C. C. H.* (2014) Reply to Hejjel. Journal of Applied Physiology 116:710
2014 Kuo, T. B. J., Chen, C. Y., Wang, Y. P., Lane Y. Y., Mak, K. H., Yang, C. C. H.* (2014) The role of autonomic and baroreceptor reflex control in blood pressure dipping and non-dipping in rats. Journal of Hypertension 32:806-816
2013 Kuo, T. B. J., Li, J. Y., Lai, C. T., Huang, Y. C., Hsu, Y. C., Yang, C. C. H.* (2013) Effect of bedding system selected by manual muscle testing on sleep-related cardiovascular functions. Biomed Research International http://dx.doi.org/10.1155/2013/937986
2013 Wang, Y. P., Kuo, T. B. J., Lai, C. T., Chu, J. W., Yang, C. C. H.* (2013) Effects of respiratory time ratio on heart rate variability and spontaneous baroreflex sensitivity. Journal of Applied Physiology 115:1648-1655
2013 Chen, C. Y., Kuo, T. B. J., Hsieh, I. T., Yang, C. C. H.* (2013) Electrical stimulation of the rostral ventrolateral medulla promotes wakefulness in rats. Sleep Medicine 14:1076-1084
2013 Lin, Y. H., Ho, Y. C., Lin, S. H., Yeh, Y. H., Liu, C. Y., Kuo, T. B. J., Yang, C. C. H., Yang, A. C.* (2013) On-call duty effects on sleep-state physiological stability in male medical interns. Plos One 8:e65072
2013 Huang, S. S., Cheng, H., Tang, C. M., Nien, M. Y., Huang, Y. S., Lee, I. H., Yin, J. H., Kuo, T. B. J., Yang, C. C. H., Tsai, S. K.*, Yang, C. C. H.* (2013) Anti-oxidative, anti-apoptotic, and pro-angiogenic effects mediate functional improvement by sonic hedgehog against focal cerebral ischemia in rats. Experimental Neurology 247:680-688
2013 Liu, K. D., Shan, D. I., Kuo, T. B. J., Yang, C. C. H.* (2013) The effects of bilateral stimulation of the subthalamic nucleus on heart rate variability in patients with Parkinson’s disease. Journal of Neurology 260:1714-1723
2013 Huang, W. L., Chang, L. R., Kuo, T. B. J., Lin, Y. H., Chen, Y. Z., Yang, C. C. H.* (2013) Gender differences in personality and heart rate variability. Psychiatry Research 209:652-657
2013 Lin, Y. C., Chen, C. Y., Lin, S. H., Liu, C. H., Weng, W. H., Kuo, T. B. J. and Yang, C. C. H.* (2013) Gender differences in cardiac autonomic modulation during medical internship. Psychophysiology 50:521-527
2012 Wang, T. S.,†, Huang, W. L.†, Kuo, T. B. J., Lee, G. S. and Yang, C. C. H.* (2012) Inattentive and hyperactive preschool-age boys have lower sympathetic and higher parasympathetic activity.. Journal of Physiological Sciences 36:87-94
2012 Kuo, T. B. J., Lai, C. T., Chen, C. Y., Lee, G. S. and Yang, C. C. H.* (2012) Unstable sleep and higher sympathetic activity during late sleep periods of rats: implication for late sleep-related higher cardiovascular events. Journal of Sleep Research 22:108-118
2012 Huang, W. L., Chang, L. R., Kuo, T. B. J., Lin, Y. H., Chen, Y. Z. and Yang, C. C. H.* (2012) Impact of Antipsychotics and Anticholinergics on Autonomic Modulation in Patients with Schizophrenia. Journal of Clinical Psychopharmacology 33:170-177
2012 Hsieh, I. T., Yang, C. C. H., Chen, C. Y., Lee, G. S., Kao, F. J., Kuo K. L. and Kuo, T. B. J.* (2012) Uninterrupted wireless long-term recording of sleep patterns and autonomic function in freely moving rats. Journal of Medical and Biological Engineering 33:79-86
2012 Chen H. C., Yang, C. C. H. , Kuo, T. B. J., Su, T. P. and Chou, P.* (2012) Cardiac vagal control and theoretical models of co-occurring depression and anxiety: A cross-sectional psychophysiological study of community elderly. BMC Psychiatry 12:93
2012 Wang, Y. P., Kuo, T. B. J., Lai, C. T., Lee, G. S. and Yang, C. C. H.* (2012) Effects of breathing frequency on baroreflex effectiveness index and spontaneous bbaroreflex sensitivity derived by sequence analysis. Journal of Hypertension 30:2151-2158
2012 Kuo, T. B. J., Chen, C. Y., Lai, C. T., Chuan, T. Y., Wu, W. Y., Tsai, S. C. and Yang, C. C. H.* (2012) Sleep Disturbance among Spontaneously Hypertensive Rats is Mediated by an α1-Adrenergic Mechanism. American Journal of Hypertension 25:1110-1117
2012 Li, J. Y., Kuo, T. B. J., Hsieh, I. T. and Yang, C. C. H.* (2012). Changes in hippocampal theta rhythm and their correlations with speed during different phases of voluntary wheel running in rats. Neuroscience 213: 54-61
2012 Ya-Chun Chua†*, Cheryl C. H. Yang †, Ho-Tien Lin, Pin-Tarng Chen, Kuang-Yi Chang, Shun-Chin Yang and Kuo, T. B. J. (2012) Neonatal nociception elevated baseline blood pressure and attenuated cardiovascular responsiveness to noxious stress in adult rats. International Journal of Developmental Neuroscience 30:421-426
2012 Huang, S. S., Su, H. H., Kuo, T. B. J., Chen, C. Y., Lan, Y. Y., Liu, B. Y., Young, D. I., Tsai, S. C. and Yang, C. C. H.* (2012) Suppressing cardiac vagal modulation and changing sleep patterns in rats after chronic ischemic stroke injury. Autonomic Neuroscience-Basic and Clinical 169:116-123
2012 Kuo, T. B. J., Chen, C. Y., Hsu, Y. C. and Yang, C. C. H.* (2012) Performance of the frequency domain indices with respect to sleep staging. Clinical Neurophysiology 123:1338-1345
2012 Huang, W. L., Lin, Y. H., Kuo, T. B. J., Chang, L. R., Chen, Y. Z. and Yang, C. C. H.* (2012) Methadone-mediated autonomic functioning of male patients with heroin dependence: the influence of borderline personality pattern. PLoS ONE 7:e37464
2012 Wang, Y. C., Chen, C. Y., Kuo, T. B. J., Lai, C. J. and Yang, C. C. H.,* (2012) The influences of antipsychotic agents on the heart rate variability in male WKY rats: implications for cardiovascular safety. Neuropsychobiology 65:216-226
2012 Chung, M. H., Kuo, T. B. J., Hsu, N., Chu, H., Chou, K. R. and Yang, C. C. H.* (2012) Recovery after three-shift work: relation to sleep-related cardiac neuronal regulation in nurses. Industrial Health 50:24-30
2012 Chang, L. R., Lin, Y. H., Kuo, T. B. J., Ho, Y. C., Chen, S. H., Wu Chang, H. C., Liu, C. M. and Yang, C. C. H.* (2012) Cardiac autonomic modulation during methadone therapy among heroin users: a pilot study. Progress in Neuro-Psychopharmacology & Biological Psychiatry 37:188-193
2012 Chen, P. L., Kuo, T. B. J., and Yang, C. C. H.* (2012) Parasympathetic activity correlates with early outcome in patients with large artery atherosclerotic stroke. Journal of the Neurological Sciences 314:57-61
2012 Lin, Y. H., Kuo, T. B. J., Ho, Y. C., Lin, S. H., Liu, C. Y. and Yang, C. C. H.* (2012) Physiological and psychological impacts on male medical interns of on-call duty. Stress 15:21-30
2011 Chang, L. R., Lin, Y. H., Kuo, T. B. J., Wu Chang, H. C., Liu, C. M., Liu, C. C., Hwu, H. G., and Yang, C. C. H.* (2011) Autonomic Modulation and Health-related Quality of Life among Schizophrenic Patients Treated with Non-intensive Case Management. PLoS ONE 6:e26378
2011 Chung, M. H., Kuo, T. B. J., Hsu, N., Chuo, K. R., Chu, H. and Yang, C. C. H.* (2011) Comparison of sleep-related cardiac autonomic function between rotating-shift and permanent night-shift workers. Industrial Health 49:589-596
2011 Kuo, T. B. J., Li, J. Y.†, Chen, C. Y., and Yang, C. C. H.* (2011) Changes in hippocampal theta activity during initiation and maintenance of running in the rat. Neuroscience 194:27-35
2011 Chen, S. Y., Yang, C. C. H., Kuo, T. B. J. and Harnod T.* (2011) Association of heart rate variability with clinical outcome in parkinsonian patients after subthalamic deep brain stimulation: A retrospective cohort study. Journal of the Formosan Medical Association 110:593-599
2011 Huang, Y. M., Yang, C. C. H., Lai, C. J. and Kuo, T. B. J.* (2011) The influence of autonomic interventions on the sleep-wake related changes in gastric myoelectrical activity in rats. Neurogastroenterology & Motility 23: 560-e208
2011 Kung, Y. Y., Yang, C. C. H., Chiu, J. H. and Kuo, T. B. J.* (2011) The relationship of subjective sleep quality and cardiac autonomic nervous system in postmenopausal women with insomnia under auricular acupressure. Menopause 18: 638-645
2011 Kuo, T. B. J., Yuan, Z. F., Lin, Y. S., Lin, Y. N., Li, W. S., Yang, C. C. H. and Lai, C. J.* (2011) Reactive oxygen species are the cause of the enhanced cardiorespiratory response induced by intermittent hypoxia in conscious rats. Respiratory Physiology & Neurobiology 175:70-79
2011 Chen, C. Y., Yang, C. C. H., Lin, Y. Y. and Kuo, T. B. J.* (2011) Locomotion-induced hippocampal theta is independent of visual information in rats during movement through a pipe. Behavioural Brain Research 216:699-704
2010 Chen, W. L., Tsai, T. H., Yang, C. C. H. and Kuo, T. B. J.* (2010) Effects of ephedra on autonomic nervous modulation in healthy young adults. Journal of Ethnopharmacology 130:563-568
2010 Chen, W. L., Tsai, T. H., Yang, C. C. H. and Kuo, T. B. J.* (2010) Acute effects of ephedra on autonomic nervous modulation in healthy young adults. Clinical Pharmacology and Therapeutics 88:39-44
2010 Kuo, T. B. J.†, Li, J. Y.†, Hsieh, S. S. Y., Chen, J. J., Tsai, C. Y., and Yang, C. C. H.* (2010) Effect of aging on treadmill exercise induced theta power in the rat. Age 32:297-308
2010 Kuo, T. B. J., Lai, C. T., Hsu, F. C., Tseng, Y. J., Li, J. Y., Shieh, K. R., Tsai, S. C., and Yang, C. C. H.* (2010) Cardiac neural regulation oscillates with the estrous cycle in freely moving female rats: the role of endogenous estrogens. Endocrinology 151:2613-2621
2010 Lai, I. C., Yang, C. C. H., Kuo, T. B. J., and Shieh, K. R.* (2010) Transcranial magnetic stimulation for auditory hallucination in severe schizophrenia: partial efficacy and acute elevation of sympathetic modulation. Psychiatry and Clinical Neurosciences 64:333-335
2010 Hsin, Y., Yang, C. C. H., Kuo, T. B. J., and Harnod, T.* (2010) Effects of chronic epilepsy on heart rate variability. Neural Regeneration Research 5:156-160
2010 Huang, Y. M., Yang, C. C. H., Lai, C. J., and Kuo, T. B. J.* (2010) Involvement of sympathetic function in the sleep-related change of gastric myoelectrical activity in rats. Journal of Sleep Research 19:192-200
2010 Kuo, H. K., Yang, C. C. H., Yu, Y. H., Tsai, K. T., Chen, C. Y.* (2010) Gender-specific association between self-reported sleep duration and falls in high-functioning older adults. Journals of Gerontology Series A: Biological Sciences and Medical Sciences 65:190-196
2010 Chen, H. C., Yang, C. C. H., Kuo, T. B. J., Su, T. P., and Chou, P.* (2010) Gender differences in the relationship between depression and cardiac autonomic function among community elderly. International Journal of Geriatric Psychiatry 25:314-322
2009 Sun, T. B.*, Kuo, T. B. J., and Yang, C. C. H. (2009) Power spectral analysis of perfusion signals on free radial forearm flap transplantation in humans. Microsurgery 29:636-643
2009 Sun, T. B.*, Kuo, T. B. J., and Yang, C. C. H. (2009) Nonparallel cutaneous microcirculatory responses to pharmacologic alterations of systemic arterial pressure in rats. Microsurgery 29:319-325
2009 Chung, M. H., Kuo, T. B. J., Hsu, N., Chu, H., Chou, K. R., and Yang, C. C. H.* (2009) Sleep and autonomic nervous system changes - enhanced cardiac sympathetic modulations during sleep in permanent night shift nurses. Scandinavian Journal of Work Environment & Health 35:180-187
2009 Kuo, T. B. J., and Yang, C. C. H.* (2009) Frequency domain analysis of electrooculogram and its correlation with cardiac sympathetic function. Experimental Neurology 217:38-45
2009 Kuo, T. B. J., Yang, C. C. H.*, and Huang, N. E. (2009) Quantification of Respiratory Sinus Arrhythmia Using Hilbert-Huang Transform. Advances in Adaptive Data Analysis 1:295-307
2009 Chen, C. J.†, Kuo, T. B. J.†, Tseng, Y. J., and Yang, C. C. H.* (2009) Combined cardiac sympathetic excitation and vagal impairment in patients with non-organic erectile dysfunction. Clinical Neurophysiology 120:348-352
2009 Harnod, T., Yang, C. C. H., Hsin, Y. L., Wang, P. J., Shieh, K. R., and Kuo, T. B. J.* (2009) Heart rate variability in patients with frontal lobe epilepsy. Seizure: European Journal of Epilepsy 18:21-25
2009 Chung, M. H., Chang, F. M., Yang, C. C. H., Kuo, T. B. J., and Hsu, N.* (2009) Sleep quality and morning ness-eveningness of shift nurses. Journal of Clinical Nursing 18:279-284
2008 Wang, Y. C., Yang, C. C. H., Bai, Y. M., and Kuo, T. B. J.* (2008) Heart rate variability in schizophrenic patients switched from typical antipsychotic agents to amisulpride and olanzapine: 3-month follow-up. Neuropsychobiology 57:200-205
2008 Yang, C. C. H., Yeh, I. T., Lai, H. Y., Chen, H. I., and Kuo, T. B. J.* (2008) Dynamic effects of respiration on aortic blood flow and its autonomic control in rats. Clinical and Experimental Pharmacology and Physiology 35:1294-1300
2008 Li, J. Y.†, Kuo, T. B. J.†, Hsieh, S. S., and Yang, C. C. H.* (2008) Changes in electroencephalogram and heart rate during treadmill exercise in the rat. Neuroscience Letters 434:175-178
2008 Kuo, T. B. J., Shaw, F. Z., Lai, C. J., and Yang, C. C. H.* (2008) Asymmetry in sympathetic and vagal activities during sleep-wake transitions. Sleep 31:311-320
2008 Lai, I. C.*, Yang, C. C. H., Kuo, T. B. J., Wang, Y. C., and Shieh, K. R. (2008) Immediate impact of electroconvulsive therapy on cardiac autonomic function in schizophrenia: A preliminary study. Schizophrenia Research 100:353-355
2008 Harnod, T., Yang, C. C. H., Hsin, Y. L., Wang, P. J., Shieh, K. R. and Kuo, T. B. J.* (2008) Heart rate variability in children with refractory generalized epilepsy. Seizure: European Journal of Epilepsy 17:297-301
2008 Yi, C. H., Chen, C. L.*, Kuo, T. B. J. and Yang, C. C. H. (2008) The effect of acid suppression on sleep and cardiac autonomic regulation in GERD. Hepatogastroenterology 55:1649-1652
2008 Chen, C. L.*, Yi, C. H., Kuo, T. B. J. and Yang, C. C. H. (2008) Effect of acid suppression on gastric myoelectrical activity in GERD. Hepatogastroenterology 55:1353-1355
2008 Fu, C. H., Yang, C. C. H., Lin, C. L. and Kuo, T. B. J.* (2008) Alteration of cardiovascular autonomic functions by vegetarian diets in postmenopausal women is related to LDL cholesterol levels. Chinese Journal of Physiology 51:100-105
2007 Lee, G. S., Hsiao, T. Y., Yang, C. C. H. and Kuo, T. B. J.* (2007) Effects of speech noise on ocal fundamental frequency using power spectral analysis. Ear and Hearing 28:343-350
2007 Chen, C. L., Yang, C. C. H. and Kuo, T. B. J.* (2007) Transfer function analysis of heart rate variability correlated with gastric myoelectrical activity using a liquid nutritional meal compared to water: are they different? Chinese Journal of Physiology 50:271-276
2006 Chen, K. Y., Chen, C. L.*, Yang, C. C. H., Kuo, T. B. J. (2006) Cardiac autonomic dysregulation in patients with acute hepatitis. American Journal of the Medical Sciences 332:164-167
2006 Chen, C. L.*, Orr, W. C., Yang, C. C. H. and Kuo, T. B. J. (2006) Cardiac autonomic regulation differentiates reflux disease with and without erosive esophagitis. Scandinavian Journal of Gastroenterology 41:1001-1006
2006 Fu, C. H., Yang, C. C. H. and Kuo, T. B. J.* (2006) Age-Related Changes in Cerebral Hemodynamics and Their Correlations with Cardiac Autonomic Functions. Neurological Research 28:871-876
2006 Lai, C. J., Yang, C. C. H., Hsu, Y. Y., Lin, Y. N. and Kuo, T. B. J.* (2006) Enhanced sympathetic activity and decreased baroreflex sensitivity are associated with intermittent hypoxia-induced systemic hypertension in conscious rats. Journal of Applied Physiology 100:1974-1982
2006 Lee, G. S., Yang, C. C. H. and Kuo, T. B. J.* (2006) Voice low tone to high tone ratio: a potential quantitative index for vowel [a:] and its nasalization. IEEE Transactions on Biomedical Engineering 53:1437-1439
2006 Sun, T. B., Yang, C. C. H. and Kuo, T. B. J.* (2006) Effect of Hyperbaric oxygen on Cardiac Neural Regulation in Diabetic Individuals with Foot Complications. Diabetic Medicine 23:360-366
2006 Sun, T. B., Yang, C. C. H., Lai, C. J. and Kuo, T. B. J.* (2006) Time course of cardiovascular neural regulation during programmed 20-sec apnea in rats. Critical Care Medicine 34:765-770
2006 Fu, C. H., Yang, C. C. H., Lin, C. L. and Kuo, T. B. J.* (2006) Effects of long-term vegetarian diets on cardiovascular autonomic functions in healthy postmenopausal women. American Journal of Cardiology 97:380-383
2005 Kuo, T. B. J.†, Lai, C. J.†, Huang, Y. T. and Yang, C. C. H.* (2005) Regression analysis between heart rate variability and baroreflex-related vagus nerve activity in rats. Journal of Cardiovascular Electrophysiology 16:864-869
2005 Fu, C. H., Yang, C. C. H. and Kuo, T. B. J.* (2005) Effects of different classes of antihypertensive drugs on cerebral hemodynamics in elderly hypertensive patients. American Journal of Hypertension 18:1621-1625
2005 Lee, G. S., Yang, C. C. H., Wang, C. P. and Kuo, T. B. J.* (2005) Effect of nasal decongestion on voice spectrum of a nasal consonant-vowel. Journal of Voice 19:71-77
2005 Kuo, T. B. J. and Yang, C. C. H.* (2005) Sleep-related changes in cardiovascular neural regulation in spontaneously hypertensive rats. Circulation 112:849-854
2005 Chen, H. Y.†, Kuo, T. B. J.†, Shaw, F. Z., Lai, C. J. and Yang, C. C. H.* (2005) Sleep-related vagotonic effect of zolpidem in rats. Psychopharmacology (Berl) 181:270-279
2004 Kuo, T. B. J. and Yang, C. C. H.* (2004) Scatterplot analysis of EEG slow-wave magnitude and heart rate variability: an integrative exploration of cerebral cortical and autonomic functions. Sleep 27:648-656
2004 Kuo, T. B. J., Shaw, F. Z., Lai, C. J., Lai, C. W. and Yang, C. C. H.* (2004) Changes in sleep patterns in spontaneously hypertensive rats. Sleep 27:406-412
2004 Chen, C. L., Lin, H. H., Orr, W. C., Yang, C. C. H. and Kuo, T. B. J.* (2004) Transfer function analysis of heart rate variability in response to water intake: correlation with gastric myoelectrical activity. Journal of Applied Physiology 96:2226-2230
2004 Lai, H. Y., Yang, C. C. H., Cheng, C. F., Huang, F. Y., Lee, Y., Shyr, M. H. and Kuo, T. B. J.* (2004) Effect of esmolol on positive-pressure ventilation-induced variations of arterial pressure in anaesthetized humans. Clinical Science (Lond) 107:303-308
2004 Kuo, T. B. J., Lai, C. J., Shaw, F. Z., Lai, C. W. and Yang, C. C. H.* (2004) Sleep-related sympathovagal imbalance in SHR. American Journal of Physiology-Heart and Circulatory Physiology 286:H1170-H1176
2003 Yang, C. C. H.* and Kuo, T. B. J. (2003) Dynamic regulation of arterial blood pressure from the brainstem. Tzu Chi Medical Journal 15:1-12
2003 Kuo, T. B. J., Chern, C. M., Yang, C. C. H., Hsu, H. Y., Wong, W. J., Sheng, W. Y. and Hu, H. H.* (2003) Mechanisms underlying phase lag between systemic arterial blood pressure and cerebral blood flow velocity. Cerebrovascular Diseases 16:402-409
2003 Fu, C. H., Yang, C. C. H. and Kuo, T. B. J.* (2003) Effect of angiotensin II eceptor antagonism on cerebral vasomotor reserve in humans. Journal of Cardiovascular Pharmacology 42:714-718
2003 Lee, G. S., Yang, C. C. H. and Kuo, T. B. J.* (2003) Voice low tone to high tone ratio--a new index for nasal airway assessment. Chinese Journal of Physiology 46:123-127
2003 Lai, H. Y., Yang, C. C. H., Huang, F. Y., Lee, Y., Kuo, Y. L. and Kuo, T. B. J.* (2003) Respiratory-related arterial pressure variability as an indicator of graded blood loss: involvement of the autonomic nervous system. Clinical Science (Lond) 105:491-497
2003 Liu, C. C.†, Kuo, T. B. J.† and Yang, C. C. H.* (2003) Effects of estrogen on gender-related autonomic differences in humans. American Journal of Physiology-Heart and Circulatory Physiology 285:H2188-H2193
2003 Yang, C. C. H., Shaw, F. Z., Lai, C. J., Lai, C. W. and Kuo, T. B. J.* (2003) Relationship between electroencephalogram slow-wave magnitude and heart rate variability during sleep in rats. Neuroscience Letters 336:21-24
2002 Wang, J. D., Kuo, T. B. J. and Yang, C. C. H.* (2002) An alternative method to enhance vagal activities and suppress sympathetic activities in humans.
2002 Kuo, T. B. J.* and Yang, C. C. H. (2002) Sexual dimorphism in the complexity of cardiac pacemaker activity. American Journal of Physiology-Heart and Circulatory Physiology 283:H1695-H1702
2002 Yang, C. C. H., Lai, C. W., Lai, H. Y. and Kuo, T. B. J.* (2002) Relationship between electroencephalogram slow-wave magnitude and heart rate variability during sleep in humans. Neuroscience Letters 329:213-216
2000 Su, C. F.*, Kuo, T. B. J., Yang, C. C. H. and Chen, H. I. (2000) Alternation of autonomic nervous functions and cardiovascular hemodynamics in severe head injury. Taiwan Critical Care Medicine 2:129-139
2000 Liu, D. D., Yang, C. C. H., Lee, R. P. and Chen, H. I.* (2000) Opposition of rapid baroreceptor resetting by prostanoids in rabbits. Chinese Journal of Physiology 43:15-21
2000 Yang, C. C. H., Chao, T. C., Kuo, T. B. J., Yin, C. S. and Chen, H. I.* (2000) Preeclamptic pregnancy is associated with increased sympathetic and decreased parasympathetic control of HR. American Journal of Physiology-Heart and Circulatory Physiology 278:H1269-H1273
2000 Kuo, T. B. J. and Yang, C. C. H.* (2000) Altered frequency characteristic of central vasomotor control in SHR. American Journal of Physiology-Heart and Circulatory Physiology 278:H201-H207
2000 Yang, C. C. H. and Kuo, T. B. J.* (2000) Impact of pulse pressure on the respiratory-related arterial pressure variability and its autonomic control in the rat. European Journal of Physiology 439:772-780
1999 Kuo, T. B. J.*, Lin, T., Yang, C. C. H., Li, C. L., Chen, C. F. and Chou, P. (1999) Effect of aging on gender differences in neural control of heart rate. American Journal of Physiology-Heart and Circulatory Physiology 277:H2233-H2239
1999 Yang, C. C. H. and Kuo, T. B. J.* (1999) Assessment of cardiac sympathetic regulation by respiratory-related arterial pressure variability in the rat. Journal of Physiology 515:887-896
1997 Yang, C. C. H., Kuo, T. B. J. and Chan, S. H. H.* (1997) Functional characterization of caudal hypoglossal neurons by spectral patterns of neuronal discharges in the rat. Neuroscience 77:813-827
1997 Kuo, T. B. J., Yang, C. C. H. and Chan, S. H. H.* (1997) Selective activation of vasomotor component of SAP spectrum by nucleus reticularis ventrolateralis in rats. American Journal of Physiology-Heart and Circulatory Physiology 272:H485-H492
1997 Kuo, T. B. J., Yien, H. W., Hseu, S. S., Yang, C. C. H., Lin, Y. Y., Lee, L. C. and Chan, S. H. H.* (1997) Diminished vasomotor component of systemic arterial pressure signals and baroreflex in brain death. American Journal of Physiology-Heart and Circulatory Physiology 273:H1291-H1298
1996 Yang, C. C. H., Chan, S. H. H. and Chan, J. Y. H.* (1996) Physiological> Role of Brain Angiotensin III in Drinking Behavior in the Rat. Journal of Biomedical Science 3:203-210
1996 Kuo, T. B. J., Yang, C. C. H., Chan, J. Y. H., Tsai, H. F. and Chan, S. H. H.* (1996) Further Characterization of Nociception-Related and Arterial Pressure-Related Neuronal Responses in the Nucleus Reticularis Gigantocellularis of the Rat. Journal of Biomedical Science 3:338-347
1996 Yang, C. C. H., Kuo, T. B. J. and Chan, S. H. H.* (1996) Auto- and cross-spectral analysis of cardiovascular fluctuations during pentobarbital anesthesia in the rat. American Journal of Physiology-Heart and Circulatory Physiology 270:H575-H582
1996 Kuo, T. B. J., Yang, C. C. H. and Chan, S. H. H.* (1996) Transfer function analysis of ventilatory influence on systemic arterial pressure in the rat. American Journal of Physiology-Heart and Circulatory Physiology 271:H2108-H2115
1995 Yang, C. C. H., Kuo, T. B. J., Chan, S. H. H., and Chan, J. Y. H.* (1995) Neurobiology of central angiotensin III and dipsogenesis. Biological Signals 4:59-71
1995 Yang, C. C. H., Chan, J. Y. H. and Chan, S. H. H.* (1995) Excitatory innervation of caudal hypoglossal nucleus from nucleus reticularis gigantocellularis in the rat. Neuroscience 65:365-374
1995 Yang, C. C. H., Chan, J. Y. H. and Chan, S. H. H.* (1995) Central effect of angiotensin III on caudal hypoglossal neurons in rats. American Journal of Physiology 268:R1242-1248
1994 Yang, C. C. H., Chan, J. Y. H., Pan, J. T. and Chan, S. H. H.* (1994) Differential neuronal responses to angiotensin III from the subfornical organ of normotensive and spontaneously hypertensive rats. Brain Research 638:169-174
1993 Yang, C. C. H., Chan, J. Y. H. and Chan, S. H. H.* (1993) Unsustained dipsogenic response to chronic central infusion of angiotensin-III in spontaneously hypertensive rats. Endocrinology 132:405-409
Publish Date Patent Title Patent Number Patent Country Authors
2014/05/10 I437458
2014/03/10 I432070
2012/12/10 Sleep analysis system and method for analyzing sleep thereof. US Patent 8,292,819 B2 美國
2011/02/10 I337536
2010/08/10 Earphone sensor system for measuring electrocardiogram signals 7,769,435 B2 美國
2010/03/10 I321227
2010/03/10 Miniature wireless apparatus for collecting physiological signals 7,672,714 B2 美國
2009/11/10 I316401
2009/08/10 I313593
2009/07/10 I31190
2007/10/10 Methods and Apparatus for Analyzing Heart Rate Variability 7,277,746 美國
2006/09/10 261415
2006/08/10 ZL03143197.6
2006/07/10 ZL03109155.5
2006/05/10 I254504
2006/01/10 Pulse interval to voltage converter and conversion method thereof 6,989,693 美國
2004/12/10 225394
2004/04/10 198840
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