Fu-Jung Hsiao
Biomedical Technologies
Name Fu-Jung Hsiao
Email fujunghsiao@gmail.com
Office Tel No. 28267000-6158
POSITION TITLE/AFFILIATIONS Associate Researcher/Brain Research Center
EDUCATION/TRAINING 2005 Ph.D, degree in Biomedical Engineering. National Yang-Ming University, Taiwan
2000 MS degree in Biomedical Engineering. Chung-Yuan University, Taiwan
Research Electrophysiological signatures of neurological diseases

My current research aims at exploring the electrophysiological signatures of neurological diseases, including epilepsy, Alzheimer’s disease, migraine, fibromyalgia, Paroxysmal kinesigenic dyskinesia, and patients with carotid stenosis, by using MEG and EEG recordings. To extract the important features, advanced multi-domain (time, frequency, phase, and space) data analysis is utilized with current source technique (Minimum norm estimates). It provides the neurophysiological mechanism with fine temporal and spatial information. For example, we discovered the neural correlates of somatosensory paired-pulse suppression (Hsiao et al. NeuroImage, 2013) and theta activities characterizing the auditory change detection processing in/between the temporal and frontal cortex (Hsiao et al. Biol. Psychol. 2009, 2010). Alzheimer’s disease is known as disconnection syndrome. By auditory oddball and resting-state task, in AD, we found the deterioration of temporo-frontal connection for deviant stimuli (Hsiao et al. Hum. Brain Map.  2014) and the disruption of the default mode network (Hsiao et al. PLoS ONE, 2013) and enhancement of the sensorimotor network (Hsiao et al. Neurosci. Lett., 2014). Epilepsy is characterized by recurrent and unprovoked seizures. In temporal lobe epilepsy, reinforced default mode network reflected the alterations of the resting-state functional connectivity (Hsiao et al. under review). Using resting state EEG recording, the altered cerebral hemodynamics and cognitive impairment for asymptomatic carotid stenosis was characterized by augmented theta and attenuated alpha activities in the cortical regions (Hsiao et al. Clin. EEG and Neurosci., In revision). Now, to further investigate the underlying mechanisms and the biomarkers, resting-state MEG/EEG recording will be carried out on the epilepsy, Alzheimer’s disease, migraine, and fibromyalgia patients. Besides, the measurement of cortical excitability and autonomic system for migraine and fibromyalgia patients using paired-pulse paradigm and heart rate variability analysis is also our future work .
Year Paper Title
2021 11, 2, pp166-
2021 11, 1311
2021 24, 12, pp82-
2020 21, 1, pp133-
2020 9, 2, pp765-781
2020 5, 34, pp450-462
2020 12, 4, pp3911-3925
2020 12, 39
2020 48, 4
2019 Hung-Ming Wu, Fu-Jung Hsiao#, Rou-Shayn Chen, Din-E Shan, Wan-Yu Hsu, Ming-Chang Chiang, Yung-Yang Lin., Attenuated NoGo-related beta desynchronisation and synchronisation in Parkinson’s disease revealed by magnetoencephalographic recording, Sci. Rep., (Accepted)
2018 Yo-Tsen Liu, Yi-Chieh Chen, Shang-Yeong Kwan, Chine-Chen Chou, Hsiang-Yu Yu, Der-Jen Yen, Kwong-Kum Liao, Wei-Ta Chen, Yung-Yang Lin, Rou-Shayn Chen, Kang-Yang Jih, Shu-Fen Lu, Yu-Te Wu, Po-Shan Wang, Fu-Jung Hsiao*, Aberrant sensory gating of the primary somatosensory cortex contributes to the motor circuit dysfunction in paroxysmal kinesigenic dyskinesia., Front Neurol., Oct 15;9, pp831-
2018 Wei-Ta Chen, Fu-Jung Hsiao#, Yu-Chieh Ko, Liu HY, Wang PN, Fuh JL, Lin YY, Wang SJ., Comparison of somatosensory cortex excitability between migraine and "strict-criteria" tension-type headache: a magnetoencephalographic study., Pain., Apr;159(4), pp793-803
2018 Chen WT, Chou KH, Lee PL, Hsiao FJ, Niddam DM, Lai KL, Fuh JL, Lin CP, Wang SJ., Comparison of gray matter volume between migraine and "strict-criteria" tension-type headache., J Headache Pain., Jan 15;19(1), pp4-
2018 Fu-Jung Hsiao*, Wei-Ta Chen, Yung-Yang Lin., Association between stimulus-evoked somatosensory inhibition and movement-related sensorimotor oscillation: A magnetoencephalographic study., Neuroscience letters, 664, pp74-78
2018 Fu-Jung Hsiao, Shuu-Jiun Wang, Yung-Yang Lin, Jong-Ling Fuh, Yu-Chieh Ko, Pei-Ning Wang, Wei-Ta Chen., Somatosensory gating is altered and associated with migraine chronification: A magnetoencephalographic study., Cephalalgia., Apr;38(4), pp744-753
2017 Fu-Jung Hsiao, Shuu-Jiun Wang, Yung-Yang Lin, Jong-Ling Fuh, Yu-Chieh Ko, Pei-Ning Wang, Wei-Ta Chen., Altered insula–default mode network connectivity in fibromyalgia: a resting-state magnetoencephalographic study., Journal of Headache and Pain., 18(1), pp89-
2017 Liu HY, Chou KH, Lee PL, Fuh JL, Niddam DM, Lai KL, Hsiao FJ, Lin YY, Chen WT, Wang SJ, Lin CP., Hippocampus and amygdala volume in relation to migraine frequency and prognosis., Cephalalgia., Dec;37(14), pp1329-1336
2017 Fu-Jung Hsiao*, Wan-Yu Hsu, Wei-Ta Chen, Rou-Shayn, Yung-Yang Lin*, Abnormal Somatosensory Synchronization in Patients With Paroxysmal Kinesigenic Dyskinesia: A Magnetoencephalographic Study., Clinical EEG and Neuroscience, 48(4), pp288-294
2016 Fu-Jung Hsiao*, Fang-Yuh Hsieh, Wei-Ta Chen, Da-Chen Chu, Yung-Yang Lin*, Altered Resting State Cortical EEG Oscillations in Patients with Severe Asymptomatic Carotid Stenosis., Clinical EEG and Neuroscience , 47(2), pp142-149
2015 Fu-Jung Hsiao*, Hsiang-Yu Yu, Wei-Ta Chen, Shang-Yeong Kwan, Chien Chen, Der-Jen Yen, Chun-Hing Yiu, Yang-Hsin Shih, Yung-Yang Lin*, Increased intrinsic connectivity of the default mode network in temporal lobe epilepsy: evidence from resting state MEG recording., PLoS ONE 10(6):e0128787.
2015 Chia-Hsiung Cheng, Sylvain Baillet, Fu-Jung Hsiao, Yung-Yang Lin. , Effects of aging on the neuromagnetic mismatch detection to speech sounds., Biol Psychol., 104, pp48-55
2014 Connectivity features for identifying cognitive impairment in presymptomatic carotid stenosis. PLoS ONE 15;9(1):e85441.
2014 Altered Source-based EEG Coherence of Resting-State Sensorimotor Network in Early-Stage Alzheimer’s Disease Compared to Mild Cognitive Impairment. Neurosci Lett. 13;558:47-52.
2014 Fu-Jung Hsiao*, Wei-Ta Chen, Pei-Ning Wang, Chia-Hsiung Cheng, Yung-Yang Lin*, Temporo-frontal functional connectivity during auditory change detection is altered in Alzheimer’s disease, Hum Brain Map., 35(11), pp5565-5577
2014 Reduced Motor Cortex Deactivation in Individuals Who Suffer from Writer's Cramp, PLoS ONE 9(5):e97561.
2013 Neural correlates of somatosensory paired-pulse suppression: A MEG study using distributed source modeling and dynamic spectral power analysis. Neuroimage 15;72:133-42. (IF: 6.252, 3/120 = 2.5%)
2013 Altered Oscillation and Synchronization of Default-Mode Network Activity in Mild Alzheimer’s Disease Compared to Mild Cognitive Impairment: An Electrophysiological Study. PLoS ONE 8(7): e68792.
2013 Effects of aging on neuromagnetic mismatch responses to pitch changes. Neurosci Lett. 7;544:20-4.
2010 Fu-Jung Hsiao, Chen-Chuan Hung, Noninvasive blood pressure analysis using empirical mode decomposition - based Oscillometric method, 2010 3rd International Conference on Biomedical Engineering and Informatics (BMEI), Volume 3, Page(s): 973 – 977. (EI)
2010 Measurements of Functional Connectivity Between Cerebral Regions During Auditory Sensory Memory Processing, 2010 3rd International Conference on Biomedical Engineering and Informatics (BMEI), Volume 3, Page(s): 939 – 942. (EI)
2010 Fu-Jung Hsiao, Chia-Hsiung Cheng, Kwong-Kum Liao, Yung-Yang Lin*, Fu-Jung Hsiao, Chia-Hsiung Cheng, Kwong-Kum Liao, Yung-Yang Lin*, 2010. Cortico-cortical phase synchrony in auditory mismatch processing. Biol. Psychol. 84(2), 336-345. 
2009 Fu-Jung Hsiao, Zin-An Wu, Low-Tone Ho, Yung-Yang Lin*, 2009. Theta oscillation during auditory change detection: An MEG study. Biol. Psychol., 81(1), 58-66.
2008 Fu-Jung Hsiao, Wei-Ta Chen, Kwong-Kum Liao, Zin-An Wu, Low-Tone Ho, Yung-Yang Lin*, 2008. Oscillations in the theta (4-8 Hz) and alpha (8-13 Hz) band increase in the human secondary somatosensory cortex during nociceptive information processing. Can. J. Neurol. Sci., 35(5), 630-637.
2007 Fu-Jung Hsiao, Wei-Ta Chen, Yung-Yang Lin, Oscillatory characteristics in the secondary somatosensory (SII) cortex in response to nociceptive stimuli, Electronic and Ubiquitous Technology for Excellent Healthcare, Tzu Chi Univ., Taiwan, 1, 346-356, 2007
2007 Altered neuromagnetic responses to pattern reversal visual stimulation in patients with migraine, International Congress Series, Volume 1300, June 2007, Pages 531-534.
2007 Plastic phase-locking of brain responses to deviants in temporal lobe epilepsy. Cerebral Cortex 17, 2516-2525.
2006 Bilateral oscillations for lateralized spikes in benign rolandic epilepsy. Epilepsy Res. 69, 45-52.
2006 Oscillatory characteristics of face-evoked neuromagnetic responses. Int. J. Psychophysiol. 61, 113-120.
2005 The effects of face spatial frequencies on cortical processing revealed by magnetoencephalography. Neurosci. Lett. 380, 54-59.