Shuu-Jiun Wang
Director,Clinical Neuroscience
Name Shuu-Jiun Wang
Office Tel No. +886-2-28712121 ext. 7578
POSITION TITLE/AFFILIATIONS Professor of Neurology/ National Yang-Ming University School of Medicine Chairman/ Faculty of Medicine, National Yang-Ming University School of Medicine Deputy Head/ Neurological Institute, Taipei Veterans General Hospital
EDUCATION/TRAINING National Yang-Ming University School of Medicine, Taipei, TAIWAN. Taipei Veterans General Hospital, Taipei, TAIWAN (Resident in Neurology ) Comprehensive Headache Center at Germantown Hospital and Medical Center; Temple University Medical School Philadelphia, PA, USA ( Fellow)
Research Headache, Pain, Dementia

After completion of my fellowship training in the United States at the affiliated headache center of Temple University in Philadelphia, I established, in collaboration with Professor Jong-Ling Fuh, the Headache Team at Taipei Veterans General Hospital. After nearly 20 years' of continuous operation, the VGH Headache Team has become one of the most renowned and respected medical groups worldwide. In addition to providing state-of-the-art clinical service, the VGH Headache Team has made some remarkable academic achievements in the field of headache medicine.
Year Paper Title
2021 11, 2, pp166-
2021 24, 12, pp82-
2020 40, 5, pp427-428
2020 23, 5, pp529-536
2020 40, 3, pp321-322
2020 21, 1, pp133-
2020 9, 2, pp765-781
2019 Yang MH, Wang PH, Wang SJ, Sun WZ, Oyang YJ, Fuh JL. Women with endometriosis are more likely to suffer from migraines: a population-based study. PLoS ONE 7(3): e33941.
2014 Chen PL, Yang CW, Tseng YK, Sun WZ, Wang JL, Wang SJ, Oyang YJ, Fuh JL. Risk of dementia after anaesthesia and surgery. Br J Psychiatry. 2014, 204:188-193
2014 Lin KH, Chen SP, Fuh JL, Wang YF, Wang SJ*. Efficacy, safety, and predictors of response to botulinum toxin type A in refractory chronic migraine: A retrospective study. J Chin Med Assoc. 2014 Jan;77(1):10-5
2014 Kao CH, Wang SJ, Tsai CF, Chen SP, Wang YF, Fuh JL. Psychiatric comorbidities in allodynic migraineurs. Cephalalgia. 2014;34(3):211–218
2014 Lin KH, Chen YT, Fuh JL, Li SY, Chen TJ, Tang CH, Wang SJ*. Migraine is associated with a higher risk of transient global amnesia: A nationwide cohort study. Eur J Neurol 2014 May;21(5):718-24
2014 Peng KP, Wang SJ*. Epidemiology of headache disorders in Asia. Headache 2014 Apr;54(4):610-8
2014 Stovner LJ, Jumah MA, Birbeck GL, Gururaj G, Jensen R, Katsarava Z, Queiroz LP, Scher AI, Tekle-Haimanot R, Wang SJ, Steiner TJ. The methodology of population surveys of headache prevalence, burden and cost: Principles and recommendations from the Global Campaign against Headache. J Headache Pain 2014,15:5
2014 Fan AP, Buka SL, Kosik RO, Chen YS, Wang SJ, Su TP, Eaton WW. Association between maternal behavior in infancy and adult mental health: A thirty-year prospective study. Comprehensive Psychiatry 2014;55:283-289
2014 Chou KH, Yang FC, Fuh JL, Huang CC, Lirng JF, Lin YY, Lee PL, Kao HW, Lin CP, Wang SJ*. Altered white matter microstructural connectivity in cluster headaches: A longitudinal diffusion tensor imaging study. Cephalalgia 2014 (in press)
2014 Liang JF; Chen YT; Fuh JL, Li SY, Tang CH,Chen TJ, Wang SJ*. Proton pump inhibitor related-headaches: a nationwide population-based case-crossover study in Taiwan. Cephalalgia 2014 (in press)
2014 Liao YC, Lee WJ, Hwang JP, Wang YF, Tsai CF, Wang PN, Wang SJ*, Fuh JL*. ABCA7 gene and the risk of Alzheimer’s disease in Han Chinese in Taiwan. Neurobiol Aging 2014 (in press)
2014 Soong BW, Lin KP, Guo YC, Lin CC, Tsai PC, Liao YC, Lu YC, Wang SJ, Tsai CP, Lee YC. Extensive genetic analysis of a cohort of Taiwanese patients with amyotrophic lateral sclerosis. Neurobiol Aging 2014 (in press)
2014 Liang JF, Wang SJ*. Hypnic headache: A review of clinical features, therapeutic options and outcomes. Cephalalgia 2014 (in press)
2014 Altered hypothalamic functional connectivity in cluster headache: a longitudinal resting-state functional MRI study 55. Yang FC, Chou KH, Fuh JL, Lee PL, Lirng JF, Lin YY, Lin CP*, Wang SJ*. Altered hypothalamic functional connectivity in cluster headache: a longitudinal resting-state functional MRI study. J Neurol Neurosurg Psychiatry 2014 (in press) .
2013 Chen PK, Wang SJ*. Ophthalmoplegic migraine: Migraine variant or cranial neuralgia? Cephalalgia 2012;32:515-7 (editorial) Chen PK, Wang SJ*. Response to Dr. Ambrosetto. Cephalalgia 2013;33:284
2013 Yang CA, Shih-Jen Tsai SJ, Yang CH, Shia BC, Fuh JL, Wang SJ, Peng CK, Huang N Suicide and media reporting: a longitudinal and spatial analysis. Social Psychiatry and Psychiatric Epidemiology 2013;48:427-35
2013 Ou SM, Lee YJ, Hu YW, Liu CJ, Chen TJ, JL Fuh, Wang SJ*. Dose Alzheimer's disease protect against cancers? A nationwide population-based study. Neuroepidemiology 2013;40:42-9
2013 Ou SM, Liu CJ, Chang YS, Hu YW, Chao PW, Chen TJ, Tzeng CH, Wang SJ*. Tuberculosis in myasthenia gravis. Int J Tuberc Lung Dis 2013;17:79-84
2013 Chang YS, Liu CJ, Chen WS, Lai CC, Wang SH, Chen TJ, Tzeng CH, Tsai CY, Wang SJ*. Increased risk of subarachnoid hemorrhage in patients with systemic lupus erythematosus: A nationwide population-based study. Arthritis Care & Research 2013;6:601-6
2013 Chu CH, Liu CJ, Fuh JL, Shiao AS, Chen TJ, Wang SJ*. Migraine is a risk factor for sudden sensorineural hearing loss: A nationwide population-based study. Cephalalgia 2013;33:80-86 (Editorial 2013;33:77–79) (Response to the Letter to editor: 2013;33:1208)
2013 Wang SJ*, Wang PJ, Fuh JL, Peng KP, Ng K. Comparisons of disability, quality of life, and resource use between chronic and episodic migraineurs: A clinic-based study in Taiwan. Cephalalgia 2013;33:171-181 (editorial Buse DC, Lipton RB. Cephalalgia 2013;33:885-90)
2013 Stark RJ, Ravishankar K, Siow HC, Lee KS, Pepperle R, Wang SJ*. Chronic migraine and chronic daily headache in the Asia–Pacific region: a systematic review. Cephalalgia 2013;33:266-283
2013 Liang JF, Chen YT, Fuh JL, SY Li, Liu CJ, Chen TJ, Tang CH, Wang SJ*. Cluster headache is associated with an increased risk for depression: A nationwide population-based cohort study. Cephalalgia 2013;33:182-189.
2013 Tang CH, Chen YC, Ng K, Wang SJ*. A retrospective matched case-control study on medical costs of refractory migraine in Taiwan. Headache 2013;53:526-39
2013 Chen WT, Lin YY, Wang SJ. Headache frontiers: using magnetoencephalography to investigate pathophysiology of chronic migraine. Curr Pain Headache Rep 2013;17:309 (review)
2013 Tseng CM , Chen YT, Ou SM, Hsiao YH, Li SY, Wang SJ, Yang AC, Chen TJ, Perng DW. The effect of cold temperature on increased exacerbation of chronic obstructive pulmonary disease: A nationwide study. PloS ONE 2013;8(3):e57066.
2013 Yang FC, Chou KH, Fuh JL, Huang CC, Lirng JF, Lin YY, Lin CP*, Wang SJ*. Altered gray matter volume in the frontal pain modulation network in patients with cluster headache. Pain 2013;154:801–807
2013 Chou CH, Doong ML*, Fuh JL, Wu JC, Wang SJ*. Queckenstedt’s test affects more than jugular venous congestion in rat. PloS One 2013;8(3):e59409
2013 Hung CI, Liu CY, Wang SJ*. Migraine predicts physical and pain symptoms among psychiatric outpatients. J Headache Pain. 2013;14:19.
2013 Wang SH, Chang YS, Liu CJ, Lai CC, Chen WS, Chen TJ, Wang SJ*. Systemic lupus erythematosus is associated with a higher risk of cervical but not trochanteric hip fracture: A nationwide population-based study. Arthritis Care & Research 2013;65:1674–1681
2013 Chen SP, Chung YT, Liu TY, Wang YF, Fuh JL*, Wang SJ*.Oxidative stress and increased formation of vasoconstricting F2-Isoprostanes in patients with reversible cerebral vasoconstriction syndrome. Free Rad Biol Med 2013;61:243–248
2013 Chen PK, Chiu PY, Tsai IJ, Tseng HP, Chen JR, Yen SJ, Yeh SJ, Sheu JJ, Chung CP, Wu MH, Hu CJ, Chang CY, Wei CY, Yip PK, Sung SF, Wang SJ*, Hsu CY. Onset headache predicts good outcome in patients with first-ever ischemic stroke. Stroke 2013;44:1852-1858.
2013 Lu, SR, Fuh JL, Wang SJ*, Juang KD, Chen SP, Liao YC, Wang YF. Incidence and risk factors of chronic daily headache in young adolescents: A school cohort study. Pediatrics 2013;132:e9-e16.
2013 Lin KH, Wang SJ, Fuh JL, Chen SP. Effectiveness of botulinum toxin A in treatment of refractory erythromelalgia. J Chin Med Assoc. 2013 May;76(5):296-8. 37. Yang AC, Wang SJ, Lai KL, Tsai CF, Yang CH, Hwang JP, Lo MT, Huang NE, Peng CK, Fuh JL. Cognitive and neuropsychiatric correlates of EEG dynamic complexity in patients with Alzheimer’s disease. Prog Neuropsychopharmacol Biol Psychiatry 2013;47:52-61
2013 Chen SP, Yang AC, Fuh JL, Wang SJ*. Autonomic dysfunction in reversible cerebral vasoconstriction syndromes. J Headache Pain. 2013;14:94.
2013 Tsai CF, Hung CW, Lirng JF, Wang SJ, Fuh JL. Differences in brain metabolism associated with agitation and depression in Alzheimer's disease. East Asian Arch Psychiatry. 2013 Sep;23(3):86-90.
2013 Cheng CY, Tsai CF, Wang SJ, Hsu CY, Fuh JL. Sleep disturbance correlates with white matter hyperintensity in patients with subcortical ischemic vascular dementia. J Geriatr Psychiatry Neurol. 2013 Sep;26(3):158-64.
2013 Lee YJ, Chen YT, Ou SM, Li SY, Yang AC, Tang CH, Wang SJ*. Temperature variation and the incidence of cluster headache periods: A nationwide population study. Cephalalgia 2013 (in press)
2012 Hung CI, Liu CY, Wang SJ, Yao YC, Yang CH. The cut-off points of the Depression and Somatic Symptoms Scale and the Hospital Anxiety and Depression Scale in detecting non-full remission and a current major depressive episode. Int J Psychiatr Clin Pract 2012;16:33-40
2012 Tsai CF, Lee WJ, Wang SJ, Shia BC, Nasreddine Z, Fuh JL. Psychometrics of the Montreal cognitive assessment (MoCA) and its subscales: Validation of the Taiwanese version of the MoCA and an Item response theory analysis. Int Psychogeriatr  2012;24: 651–658
2012 Hung CI, Liu CY, Yang CH, Wang SJ*. The negative impact of migraine on quality of life after four weeks of treatment in patients with major depressive disorder. Psychiatry Clin Neurosci 2012; 66: 8–16
2012 Liu CJ, Chang YS, Teng CJ, Chen TJ, Ou SM, Tzeng CH, Wang SJ*. Risk of extrathymic cancer in patients with myasthenia gravis in Taiwan: a nationwide population-based study. Eur J Neurol 2012;19(5):746-51
2012 Chen SP, Fuh JL, Lirng JF, Wang SJ*. Hyperintense vessels on FLAIR Imaging in reversible cerebral vasoconstriction syndromes. Cephalalgia 2012;32:271-278
2012 Fuh JL, Wang SJ. Dependent behavior in patients with medication-overuse headache Curr Pain Headache Rep 2012;16:73-79 (review)
2012 Chen WT, Wang SJ*, Fuh JL, Ko YC, Lee YC, Hämäläinen MS, Lin YY*. Visual cortex excitability and plasticity associated with remission from chronic to episodic migraine. Cephalalgia 2012;32:537-43.
2012 Chen YC, Tang CH, Ng K, Wang SJ*. Comorbidity profiles of chronic migraine sufferers in a national database in Taiwan. J Headache Pain 2012;13:311–319
2012 Peng KP, Wang SJ*. Migraine diagnosis: Screening items, instruments, and scales. Acta Anaesthesiologica Taiwanica 2012;50:69-73.
2012 Lee WJ, Tsai CF, Gauthier S, Wang SJ, Fuh JL. The association between cognitive impairment and neuropsychiatric symptoms in patients with Parkinson’s disease dementia. Int Psychogeriatrics 2012;24:1980-7
2012 Lin WC, Tsai CF, Wang SJ, Hwang JP, Fuh JL. Comparison of the burdens of family caregivers and foreign paid caregivers of the individuals with dementia. Int Psychogeriatrics 2012;24:1953-61
2012 Liu HY, Fuh JL, Lu SR, Chen SP, Chou CH, Wang YF, Wang SJ*. Transient visual disturbances in adolescents: Migrainous feature or headache accompanied phenomenon? Cephalalgia 2012;32:1109 -15.
2012 Wang YF, Fuh JL, Chen SP, Wu JC, Wang SJ*., Clinical correlates and diagnostic utility of osmophobia in migraine. Cephalalgia 2012;32:1180–1188
2012 Peng KP, Fuh JL, Wang SJ*. High-pressure headaches: idiopathic intracranial hypertension and its mimics. Nature Rev Neurol 2012;8:700-710 (review)..
2012 Lai TH, Fuh JL, Lirng JF, Lin CP, Wang SJ*. Brainstem 1H-MR spectroscopy in episodic and chronic migraine. J Headache Pain 2012;13:645–651
Year Research Title
2019 Reversible cerebral vasoconstriction syndromes (RCVS) RCVS is a syndrome characterized by recurrent thunderclap headaches associated with spasms of intracranial arteries. We have made some important contributions to characterization of the clinical and neuroradiological presentations, and to development of standard treatment protocols. Recently, we have found associations with BDNF polymorphism and urine levels of 8-Iso-PGF2α. Future works will focus on identifying key molecules in the pathophysiology of RCVS.
2019 Spontaneous intracranial hypotension (SIH): This is a headache syndrome resulting from spinal CSF leaks, and the cardinal features include an orthostatic headache associated with neck stiffness, nausea, vomiting, hearing changes, etc. We have developed an imaging technique, i.e. heavily T2-weighted magnetic resonance myelography (HT2W MRM). HT2W MRM was proved comparable to the gold standard, computed tomographic myelography, in the localization of spinal CSF leaks. Our recent findings challenged the widely held belief that CSF leaks result from dural defects at the nerve root sleeves. Subsequent efforts will be made to identify the real location of dural defects.
2019 Pathophysiology of chronic migraine (CM): CM is characterized by frequent debilitating migraine attacks, and presents a great challenge to headache clinicians. By using magnetic resonance imaging (MRI) and magnetoencephalography (MEG), we were able to identify important functional, structural, and electrophysiological changes in the brain in patients with CM. Our recent works focus on resting-state functional MRI, voxel-based morphometry, diffusion tensor imaging, and electroencephalography (EEG).
2019 Pathophysiology of chronic migraine (CM): CM is characterized by frequent debilitating migraine attacks, and presents a great challenge to headache clinicians. By using magnetic resonance imaging (MRI) and magnetoencephalography (MEG), we were able to identify important functional, structural, and electrophysiological changes in the brain in patients with CM. Our recent works focus on resting-state functional MRI, voxel-based morphometry, diffusion tensor imaging, and electroencephalography (EEG).