Pei-Ning Wang
Clinical Neuroscience
Name Pei-Ning Wang
POSITION TITLE/AFFILIATIONS Professor/ Department of Neurology, School of Medicine, National Yang-Ming University
Attending Physicision/ Department of Neurology, Taipei Veterans General Hospital
EDUCATION/TRAINING 1983-1990 MedicineMD, National Yang-Ming University, Taipei, Taiwan
1992-1997 Resident in Neurology, Department of Neurology, Taipei Veterans General Hospital, Taipei, Taiwan
Behavior Neurology FellowshipMemory and Aging Center, University of California, San Francisco, USA
Research The biomarkers of dementia, especially Alzheimer disease (AD) in Taiwan
研究概況 My research is focus on investigating the biomarkers of dementia, especially Alzheimer disease (AD) in Taiwan. In the earlier years, we made efforts on establish the validity of the Chinese-version neuropsychological tests to make a accurate early diagnosis of mild AD and mild cognitive impairment (MCI). We published the presentations of verbal memory, executive function, language functions and daily functions in MCI and mild AD. Recently, we cooperated with experts in genetics, pharmacology, biochemistry, and neuroimaging for extending our research to the bio-molecular and neuroimaging aspects of dementia. As PI or co-Investigator on several national and hospital funded grants, I laid the groundwork for the proposed research by investigating biomarkers for early diagnosis of Alzheimer’s disease and prediction the progress from aging to mild cognitive impairment and dementia. We found the rate of hippocampal atrophy was note only higher in progressive MCI, but also in stable MCI. Longitudinally evaluating hippocampal volume may be more sensitive than neuropsychological tests to detect the progression of MCI. Last year, we published the special patterns of axonal degeneration and myelin degradation in different brain regions in MCI and mild AD. In the next few years, our research focus will be placed on inspecting the trajectory of different biomarkers from preclinical AD, MCI due to AD, to dementia due to AD.
Year Paper Title
2021 11, 1311
2020 12, 4, pp3911-3925
2020 12, 39
2019 Sung SH, Lee CW, Wang PN, Lee HY, Chen CH, Chung CP. , Cognitive functions and jugular venous reflux in severe mitral regurgitation: A pilot study., PLoS One
2019 Chuang SY, Cheng HM, Mitchell GF, Sung SH, Chen CH, Pan WH, Hwang AC, Chen LK, Wang PN* , Carotid Flow Velocities and Blood Pressures Are Independently Associated With Cognitive Function. , Am J Hypertens.
2019 Chuang SY, Lo YL, Wu SY, Wang PN, Pan WH , Dietary Patterns and Foods Associated With Cognitive Function in Taiwanese Older Adults: The Cross-sectional and Longitudinal Studies. , J Am Med Dir Assoc
2013 Chen NC, Chang CC, Lin KN, Huang CW, Chang WN, Chang YT, Chen C, Yeh YC, Wang PN*. Patterns of executive dysfunction in amnestic mild cognitive impairment. Int Psychogeriatr. 2013 Apr 11:1-9. [Epub ahead of print]
2013 Halabi C, Halabi A, Dean DL, Wang PN, Boxer AL, Trojanowski JQ, Dearmond SJ, Miller BL, Kramer JH, Seeley WW. Patterns of Striatal Degeneration in Frontotemporal Dementia. Alzheimer Dis Assoc Disord. 2013 Jan-Mar;27(1):74-83.
2012 Wang PN*, Chou KH, Lirng JF, Lin KN, Chen WT, Lin CP. Multiple diffusivities defined white matter degeneration in amnestic mild cognitive impairment and Alzheimer's disease. J Alzheimers Dis. 2012 Jan 1;30(2):423-37.
2012 Lin KN, Wang PN, Liu HC, Teng EL. Cognitive Abilities Screening Instrument, Chinese Version 2.0 (CASI C-2.0): Administration and Clinical Application. Acta Neurol Taiwan. 2012 Dec;21(4):180-9.
2012 Cheng HL, Lin CJ, Soong BW, Wang PN, Lin CP, Tu PC, Lee IH. Impairments in Cognitive Function and Brain Connectivity in Severe Asymptomatic Carotid Stenosis. Stroke. 2012 Oct;43(10):2567-73.
2012 Cheng CH, Wang PN, Hsu WY, Lin YY. Inadequate inhibition of redundant auditory inputs in Alzheimer’s disease: An MEG study. Biol Psychol. 2012 Feb;89(2):365-73
2011 Chen KD, Chang PT, Ping YH, Lee HC, Yeh CW, Wang PN*. Gene expression profiling of peripheral blood leukocytes identifies and validates ABCB1 as a novel biomarker for Alzheimer's disease. Neurobiology of Disease 2011 Sep;43(3):698-705.
2011 Chuang CC, Wang PN, Chen WT, Lan TH, Chen CM, Hsieh YC, Wan CY, Sun CW. Near-Infrared Brain Volumetric Imaging Method: A Monte Carlo Study. IEEE Journal of Selected Topics in Quantum Electronics, Epub 2011 Aug.
2011 Chen NC, Lin YI, Chang CC, Lin KN, Chuang YC, Chen C, Tu MC, Wang PN*. Learning and error patterns in the Chinese verbal learning test in subjects with mild cognitive impairment and normal elderly. Acta Neurol Taiwan. 2011 Jun;20(2):114-24
2011 Yeh YC, Lin KN, Chen WT, Lin CY, Chen TB, Wang PN*. Functional Disability Profiles in Amnestic Mild Cognitive Impairment. Dement Geriatr Cogn Disord. 2011 Apr; 7;31(3): 225-232.
2011 Chung CP, Wang PN, Wu YH, Tsao YC, Sheng WY, Lin KN, Lin SJ, Hu HH. More severe white matter changes in the elderly with jugular venous reflux. Ann Neurol. 2011 Mar;69(3):553-9.
2011 Wang PN*, Hong CJ, Lin KN, Liu HC, Chen WT. , APOE ε4 increases the risk of progression from amnestic mild cognitive impairment to Alzheimer’s disease among ethnic Chinese in Taiwan. Journal of Neurology, Neurosurgery and Psychiatry. 2011 Feb;82(2):165-9 (NSC 95-2314-B-075-002, NSC97-2314-B-010-011, V95ER3-002)
2010 Lo CY, Wang PN, Chou KH, Wang J, He Y, Lin CP. Diffusion tensor tractography reveals abnormal topological organization in structural cortical networks in Alzheimer's disease. J Neurosci. 2010 Dec 15;30(50):16876-85.
2010 Chang CC, Kramer HJ, Lin KN, Chang WN, Wang YL, Huang CW, Lin YT, Wang PN*. Validating the Chinese Version of the Verbal Learning Test for Screening Alzheimer’s Disease. Journal of International Neuropsychological Society 2010 Mar: 16 (2):244-251. (NSC 95 – 2314 - B - 075 - 002, NSC 96 - 2314 - B – 075- 001, V96C1-061)
2009 Wang PN*, Liu HC, Lirng JF, Lin KN, Wu AN. Accelerated hippocampal atrophy rates in stable and progressive amnestic mild cognitive impairment. Psychiatry Research: Neuroimaging 2009 Mar 31: 171(3):221-31 (NSC 94-2314-B-075-021, V95ER3-002)
2009 Wang PN*, Lee HC, Wang CH, Ping YH, Liu TY, Chi CW, Lin KN, Liu HC. Heteroplasmy of mitochondrial D310 mononucleonide repeat region in the blood of patients with Alzheimer’s disease. Journal of Alzheimer’s disease 2009;18(2):345-353. (NSC96-2314-B-010-051, V96ER3-001, V97ER3-002)
2009 Liu CY, Liao KK, Fuh JL, Wang PN, Shan DE, Tsai CP. Unilateral blepharospasm as an early sign of cephalic tetanus. Mov Disord. 2009 May 15;24(7):1094-5
2009 Tang CW, Wang PN, Lin, Huang DF, Wang SJ, Chen WT. Microscopic Polyangiitis Presenting with Capsular Warning Syndrome and Subsequent Stroke. J Neurol Sci. 2009 Feb 15;277(1-2):174-5.
2008 Yang PC, Wang PN, Chiang, KH, Jong YJ, Wu MT. Absence of gender effect on children with attention-deficit/hyperactivity disorder as assessed by optimized voxel-based morphometry. Psychiatry Research: Neuroimaging 2008;164: 245–253 (NSC 92-2314-B-037-099 and NSC93-2314-B-037-090)