Hui-Ching Lin
Basic Neuroscience
Name Hui-Ching Lin
Email hclin7@ym.edu.tw
Office Tel No. 02-2826-7944
POSITION TITLE/AFFILIATIONS 國立陽明大學生理學科暨生理學研究所助理教授(2011-2016)



國立成功大學藥理所博士後研究員(2008-2011)

法國馬賽國家衛生暨醫學研究院(INSERM)訪問博士後研究員(2011)

美國德州貝勒醫學中心小兒研究部門訪問博士後研究員(2010)

基隆長庚藥劑部(2000-2003)
EDUCATION/TRAINING 國立成功大學基礎醫學所博士(2008)

國立成功大學藥理所碩士(2000)

台北醫學大學藥學系藥學士(1998)
Research Brain function and emotional processes in neurological and psychiatric diseases. Electrophysiology
研究概況 1.自閉症是一種神經發育性的疾病,主要病徵為社交能力障礙與溝通能力的缺乏,且常出現反覆行為與過度焦慮反應。因此運用表現類似自閉症行為之齧齒類動物模型來探討自閉症相關大腦異常是一種具挑戰性但可能成果豐碩的方法。我們研究主要探討自閉症動物其大腦神經細胞突觸興奮性和抑制性間平衡改變的機制,並尋找藥物改善自閉症所導致之神經與行為異常。

2.現今因社經環境壓力導致人類精神疾患人口日益增多。我們研究主題著重於探討精神疾患所引起大腦功能改變的因素,並尋找調控情緒反應的關鍵蛋白。研究策略結合神經藥物、分子生物學、動物行為模式和神經電生理技術,剖析精神創傷或生理性腦血管疾病造成憂鬱,焦慮情緒障礙表現的神經生理機制。

3. 利用非藥物治療像腦部深層電刺激方式,改善神經發育性疾病或精神相關疾病,並探討其神經迴路之作用機制,其優點為減少藥物治療的使用劑量以及使用頻率,更可降低藥物所導致的副作用,開發臨床上除藥物使用之外的嶄新治療策略。
Year Paper Title
2018 Wu HF, Chen YJ, Chu MC, Hsu YT, Lu TY, Chen IT, Chen PS, Lin HC *. Deep Brain Stimulation Modified Autism-like Deficits via the Serotonin System in a Valproic Acid-Induced Rat Model. International Journal of Molecular Sciences. 2018 Sep; 19(9) pii: E2840
2018 Kuo CJ, Huang CC, Chou SY, Lo YC, Kao TJ, Huang NK, Lin C, Lin HC, Lin HC*, Lee YC*. Potential therapeutic effect of curcumin, a natural mTOR inhibitor, in tuberous sclerosis complex. Phytomedicine. 2018 Sep. (Accepted) *co-corresponding authors.
2018 Lee YC, Huang WC, Lin JH, Kao TJ, Lin HC, Lee KH, Lin HC, Shen CJ, Chang WC, Huang CC. Znf179 E3 ligase-mediated TDP-43 polyubiquitination is involved in TDP-43- ubiquitinated inclusions (UBI) (+)-related neurodegenerative pathology. Journal of Biomedical Science. 2018 Nov 8;25(1):76.
2018 Lee HT, Lee KI, Lin HC, Lee TS. Genetic Deletion of Soluble Epoxide Hydroxylase Causes Anxiety-Like Behaviors in Mice. 2018 Jul Molecular Neurobiology.
2018 Wu HF, Chen PS, Hsu YT, Lee CW, Wang TF, Chen YJ, Lin HC*. D-Cycloserine ameliorates autism-like deficits by removing GluA2-containing AMPA receptors in a valproic acid-induced rat model. Molecular Neurobiology. 2018 Jun;55(6):4811-4824.
2018 Chang LH, Lin HC, Huang SS, Chen IC, Chu KW, Chih CL, Liang YW, Lee YC, Chen YY, Lee YH, Lee IH. Blockade of soluble epoxide hydrolase attenuates post-ischemic neuronal hyperexcitation and confers resilience against stroke with TrkB activation. Scientific Reports . 2018 Jan 8;8(1):118.
2018 Yeh CH, Hsieh LP, Lin MC, Wei TS, Lin HC, Chang CC, Hsing CH. Dexmedetomidine reduces lipopolysaccharide induced neuroinflammation, sickness behavior, and anhedonia. PLoS One 2018, Jan;13 (1):e0191070.
2017 Wu HF, Chen PS, Chen YJ, Lee CW, Chen IT, Lin HC*. Alleviation of N-methyl-D-aspartate Receptor-Dependent Long-term depression via regulation of the Glycogen Synthase Kinase-3β pathway in the amygdala of a valproic acid-induced animal model of autism. Molecular Neurobiology 2017 Sep; 54(7), 5264-5276.
2017 Wu HF#, Chen YJ#, Wu SZ, Lee CW, Chen IT, Lee YC, Huang CC, Hsing CH, Tang CW, Lin HC*. Soluble epoxide hydrolase inhibitor and 14, 15-epoxyeicosatrienoic acid-facilitated long-term potentiation through cAMP and CaMKII in the hippocampus. Neural Plasticity. 2017Jul. #equal contribution.
2017 Huang HJ, Wang YT, Lin HC, Lee YH, Lin AM. Soluble Epoxide Hydrolase Inhibition Attenuates MPTP-Induced Neurotoxicity in the Nigrostriatal Dopaminergic System: Involvement of α-Synuclein Aggregation and ER Stress. Molecular Neurobiology. 2017Aug. DOI: 10.1007/s12035-017-0726-9.
2017 Wang CF, Yang SH, Lin SH, Chen PC, Lo YC, Pan HC, Lai HY, Liao LD, Lin HC, Chen HY, Huang WC, Huang WJ, Chen YY. A proof-of-principle simulation for closed-loop control based on preexisting experimental thalamic DBS-enhanced instrumental learning. Brain Stimulation 2017 Feb. pii: S1935-861X(17) 30611-3.
2017 Lee KI, Lin HC, Lee HT, Tsai FC, Lee TS. Loss of transient receptor potential ankyrin 1 channel deregulates emotional, social, cognitive, learning and memory development. Molecular Neurobiology 2017 Jul;54(5):3606-3617.
2017 Wang YT, Lin HC, Zhao WZ, Huang HJ, Lo YL, Wang HT, Lin AM. Acrolein acts as a neurotoxin in the nigrostriatal dopaminergic system of rat: involvement of α-synuclein aggregation and programmed cell death. Scientific Reports . 2017 Apr 12;7:45741.
2017 Tsou JH, Yang YC, Pao PC, Lin HC, Huang NK, Lin ST, Hsu KS, Yeh CM, Lee KH, Kuo CJ, Yang DM, Lin JH, Chang WC, Lee YC. Important roles of Ring Finger Protein 112 in embryonic vascular development and brain function. Molecular Neurobiology. 2017 Apr;54(3):2286-2300.
2016 Li CT, Lu CF, Lin HC, Huang YZ, Juan CH, Su TP, Bai YM, Chen MH, Lin WC. Cortical inhibitory and excitatory function in drug-naive generalized anxiety disorder. Brain Stimulation 2016 Dec. pii: S1935-861X(16) 30389-8.
2016 Yang SH, Chen YY, Lin SH, Liao LD, Lu HS, Wang CF, Chen PC, Lo YC, Phan TD, Chao HY, Lin HC, Lai HY, Huang WC. A sliced inverse regression (SIR) decoding the forelimb movement from neuronal spikes in the rat motor cortex. Frontiers in Neuroscience.2016 Nov. doi: 10.3389/fnins.2016.00556
2016 Chang CF, Lee YH, Lee KH, Lin HC, Chen CL, Shen CK, Huang CC. Therapeutic effect of berberine on TDP-43-related pathogenesis in FTLD and ALS. Journal of Biomedical Science 2016 Oct; 23:72.
2016 Lee KI, Lee HT, Lin HC, Tasy HJ, Tsai FC, Shyue SK, Lee TS. Role of transient receptor potential Ankyrin 1 channels in Alzheimer’s disease. Journal of Neuroinflammation 2016 Apr; 13(1): 92. doi: 10.1186/s12974-016-0557-z.
2016 Lee KI, Chiang CW, Lin HC, Zhao JF, Li CT, Shyue SK, Lee TS. Maternal exposure to di-(2-ethylhexyl) phthalate exposure deregulates blood pressure, adiposity, cholesterol metabolism and social interaction in mouse offspring. Archives of Toxicology 2016 May; 90(5): 1211-1224.
2015 Lin HC#, Pan HC#, Lin SH, Lo YC, Shen Elise TH, Liao LD, Liao PH, Chien YW, Liao KD, Jaw FS, Chu KW, Lai HY, Chen YY. Central thalamic deep-brain stimulation alters striatal–thalamic connectivity in cognitive neural behavior. #equal contribution. Frontiers in Neural Circuits 2016 Jan 13; 9:87. doi: 10.3389/fncir.2015.00087. #equal contribution.
2015 Wu HF, Yen HJ, Huang CC, Lee YC,Wu SZ , Lee TS, Lin HC*, Soluble epoxide hydrolase inhibitor enhances synaptic neurotransmission and plasticity in mouse prefrontal cortex. Journal of Biomedical Science 2015 Oct; 22:94. doi: 10.1186/s12929-015-0202-7. SCI.
2015 Lin HC#, Li CT#, David Tan TW, Cheng CW, Chou TK, Kong FL, Yu TH, Huang WS, Su DP, Liu RS, Skye Yeh HH. Non-linear alteration of serotonin transport availability in posttraumatic stress disorder measured with 4- [18F]ADAM positron emission tomography. Current Molecular Imaging 2015; 4: 57-64. #equal contribution
2015 Wang CY, Lin HC#, Song YP#, Hsu YT#, Lin SY, Hsu PC, Lin CH, Hung CC, Hsu MC, Kuo YM, Lee YJ, Hsu CY, Lee YH. 2015. Protein kinase C dependent growth-associated protein 43 phosphorylation regulates gephyrin aggregation at developing GABAergic synapses. Molecular and Cellular Biology 2015 May; 35(10):1712-1726. #equal contribution.
2014 Chen YW, Lin HC,Ng MC, Hsiao YH, Wang CC, Gean PW, Chen PS. Activation of mGluR2/3 underlies the effects of N-acetylcystein on amygdala associated autism-like phenotypes in a valproate-induced rat model of autism. Frontiers in Behavioral Neuroscience. 2014 Jun; 8: 219
2013 Wang CC#, Lin HC#, Chan YH, Gean PW, Yang YK, Chen PS. (2013). 5-HT1A-receptor agonist modified amygdala activity and amygdala-associated social behavior in a valproate-induced rat autism model. International Journal of Neuropsychopharmacology 2013 Oct; 16(9):2027-2039. # equal contribution.
2013 Lin HC, Gean PW, Wang CC, Chan YH, Chen PS. The Amygdala Excitatory/Inhibitory Balance in a Valproate-induced Rat Autism Model. PLoS One 2013, Jan; 8(1):e55248.
2011 Lin HC, Tseng YC, Mao S, Gean PW. GABAA receptor endocytosis in the basolateral amygdala is critical to the reinstatement of fear memory measured with fear-potentiated startle. The Journal of Neuroscience 2011 Tun; 31(24):8851-8861.
2010 Lin HC, Mao SC, Su CL, Gean PW. Alterations of excitatory transmission in the lateral amygdala during expression and extinction of fear memory. International Journal of Neuropsychopharmacology 2010 Apr; 13(3):335-345.
2009 Lin HC, Mao SC, Su CL, Gean PW. The role of prefrontal cortex CB1 receptors in the modulation of fear memory. Cereb Cortex 2009 Jan;19(1):165-175.
2009 Lin HC, Mao SC, Gean PW. Block of GABAA receptor insertion in the amygdala impairs extinction of conditioned fear. Biological Psychiatry 2009 Oct; 66(7) 665-673.
2009 Mao SC, Lin HC, Gean PW. Augmentation of fear extinction by infusion of glycine transporter blockers into the amygdala. Molecular Pharmacology 2009 Aug; 76(2):369-378.
2008 Lin HC, Mao SC, Chen PS, Gean PW. Chronic cannabinoid administration in vivo compromises extinction of fear memory. Learning & Memory 2008 Dec; 15(12):876-884.
2008 Mao SC, Lin HC, Gean PW. Augmentation of Fear Extinction by D-Cycloserine is Blocked by Proteasome Inhibitors. Neuropsychopharmacology 2008 Dec; 33(13):3085-3095.
2006 Lin HC, Mao SC, and Gean PW. Effects of intra-amygdala infusion of CB1 receptor agonists on the reconsolidation of fear-potentiated startle. Learning & Memory 2006 May; 13(3): 316-321.
2006 Yeh SH, Mao SC,Lin HC, Gean PW. Synaptic expression of glutamate receptor after encoding of fear memory in the rat amygdala. Molecular Pharmacology 2006 Jan; 69(1): 299-308.
2000 Lin HC, Wang SJ, Luo MZ, Gean PW. Activation of group II metabotropic glutamate receptors induces long-term depression of synaptic transmission in the rat amygdala. The Journal of Neuroscience. 2000 Dec; 20(24): 9017–9024.