連 正章
基礎神經研究團隊
姓名 連 正章
聯絡電話 Office: (02) 2826-7325 Lab: (02) 2826-7000 ext. 6090
電子郵件 cclien@ym.edu.tw
POSITION TITLE/AFFILIATIONS 國立陽明交通大學生科院院長(2020/11~)
國立陽明交通大學神經科學研究所 特聘教授&所長(2017/8/1~

德國柏林醫科大學 客座教授 (2015年迄今)

國立陽明大學神經科學研究所 副教授 (2011/2/1~2015/7/31)

國立陽明大學神經科學研究所 助理教授 (2006/7/4~2011/1/31)

加州大學柏克萊分校分子暨細胞生物所 博士後研究員
(2004/1/26~2006/7/31)

德國弗萊堡大學生理學研究所 博士後研究員 (2003/4/1~2004/2/28)
EDUCATION/TRAINING 德國弗來堡大學 醫學博士 (1998~2003)

台大醫院神經部 住院醫師 (1997/7/1~1998/6/30)

中國醫藥大學 醫學系 (1990~1997)
年度 論文名稱
2019 Enhanced Na+-K+-2Cl- cotransporter 1 underlies motor dysfunction in Huntington's disease.
2019 Hsu YT, Chang YG, Liu YC, Wang KY, Chen HM, Lee DJ, Yang SS, Tsai CH, Lien CC, Chern YJ. Enhanced Na+-K+-2Cl- cotransporter 1 underlies motor dysfunction in Huntington's disease. Mov Disord. 2019 Mar 6. [Epub ahead of print]. (Co-corresponding author)
2019 Kuo YL, Cheng JK, Hou WH, Chang YC, Du PH, Jian JJ, Rau RH, Yang JH, Lien CC, Tsaur ML. K+ channel modulatory subunits KChIP and DPP participate in Kv4-mediated mechanical pain control. J Neurosci 2017 April; 37(16): 4391-4404.
2018 Chen CY, Di Lucente J, Lin YC, Lien CC, Rogawski MA, Maezawa I, Jin LW. Defective GABAergic neurotransmission in the nucleus tractus solitarius in Mecp2-null mice, a model of Rett syndrome. Neurobiol Dis 2018 Jan; 109(Pt A): 25-32.
2017 Huang CY, Lien CC, Cheng CF, Yen TY, Chen CJ, Tsaur ML. K+ channel Kv3.4 is essential for axon growth by limiting the influx of Ca2+ into growth cones. J Neurosci 2017 April; 37(17): 4433-4449.
2016 Lee CT, Kao MH, Hou WH, Wei YT, Chen CL, Lien CC. Causal evidence for the role of specific GABAergic interneuron types in entorhinal recruitment of dentate granule cells. Sci Rep 2016 Nov; 6: 36885. (Corresponding author)
2016 Wu CC, Lien CC, Hou WH, Chiang PM, Tsai KJ. Gain of BDNF function in engrafted neural stem cells promotes the therapeutic potential for Alzheimer's disease. Sci Rep 2016 Jun; 6: 27358.
2016 Hsu TT, Lee CT, Tai MH, Lien CC. Differential recruitment of dentate gyrus interneuron types by commissural versus perforant pathways. Cereb Cortex 2016 Jun; 26(6): 2715-27. (Corresponding author)
2016 Hou WH, Kuo N, Fang GW, Huang HS, Wu KP, Zimmer A, Cheng JK, Lien CC. Wiring Specificity and Synaptic Diversity in the Mouse Lateral Central Amygdala. J Neurosci 2016 April; 36(16): 4549-4563. (Corresponding author) (Featured Article) [PDF] [PubMed]; also see Editor's Commentary
2016 Chang CP, Lee CT, Hou WH, Lin MS, Lai HL, Chien CL, Chang C, Cheng PL, Lien CC*, Chern Y. Type VI adenylyl cyclase negatively regulates GluN2B-mediated LTD and spatial reversal learning. Sci Rep 2016 Mar; 6(22529): 1-16. (*co-corresponding author)
2015 Chiang PH, Chien TC, Chen CC, Yanagawa Y, Lien CC. ASIC-dependent LTP at multiple glutamatergic synapses in amygdala network is required for fear memory. Sci Rep 2015 May 19; 5: 10143. (Corresponding author)
2015 Lin SH, Chien YC, Chiang WW, Liu YZ, Lien CC, Chen CC.Genetic mapping of ASIC4 and contrasting phenotype to ASIC1a in modulating innate fear and anxiety. Eur J Neurosci 2015 Jun; 41(12): 1553-68.
2015 Chen WT, Hsieh YF, Huang YJ, Lin CC, Lin YT, Liu YC, Lien CC, Cheng IH. G206D mutation of Presenilin-1 reduces Pen2 interaction, increases Aβ42/Aβ40 ratio and elevates ER Ca2+ accumulation. Mol Neurobiol 2015 Dec; 52(3): 1835-49.
2014 Cheng CF, Cheng JK, Chen CY, Lien CC, Chu D, Wang SY, Tsaur ML. Mirror-image pain is mediated by NGF produced from TNFactivated satellite glia after peripheral nerve injury. Pain 2014 May; 155(5): 906-20.
2014 Liu YC, Cheng JK, Lien CC. Rapid dynamic changes of dendritic inhibition in the dentate gyrus by presynaptic activity patterns. J Neurosci 2014 Jan 22; 34(4): 1344-1357. (Corresponding author)
2013 Chan CF*, Kuo TW*, Weng JY*, Lin YC*, Chen TY*, Cheng JK, Lien CC. Ba2+- and bupivacaine-sensitive background K+ conductances mediate rapid EPSP attenuation in oligodendrocyte precursor cells. J Physiol (London) 2013 Oct 1; 591(19): 4843-58. *Co-First author (Corresponding author)
2013 Sun YY, Lin SH, Lin HC, Hung CC, Wang CY, Lin YC, Hung KS, Lien CC, Kuan CY, Lee YH. Cell type-specific denpendency on the PI3K/Akt signaling pathway for the endogenous Epo and VEGF induction by baicalein in neurons versus astrocytes. PLoS ONE 2013 Jul 9; 8(7): e69019.
2013 Wu PY, Huang YY, Chen CC, Hsu TT, Lin YC, Weng JY, Chien TC, Cheng H, Lien CC. Acid-sensing ion channel-1a is not required for normal hippocampal LTP and spatial memory. J Neurosci 2013 Jan; 33 (5): 1828-32. (Corresponding author)
2012 Lee YC, Alexandra D, Majczenko K, Huang YH,Liu YC, Lien CC, Tsai PC, Ichikawa Y, Goto J, Monin ML, Li JZ, Chung MY, Mundwiller E, Shakkottai V, Liu TT, Tesson C, Lu YC, Brice A, Tsuji S, Burmeister M, Stevanin G, Soong BW. Mutations in KCND3 cause spinocerebellar ataxia type 22. Ann Neurol 2012 Dec; 72 (6): 859-69.
2012 Majumder P, Chen YT, Bose JK, Wu CC, Cheng WC, Cheng SJ, Fang YH, Chen YL, Tsai KJ, Lien CC, Shen CK. TDP-43 regulates the mammalian spinogenesis through translational repression of Rac1. Acta Neuropathol 2012 Aug; 123: 231-45. Epub 2012 Jul 4.
2012 Chiang PH*, Wu PY*, Kuo TW*, Liu YC, Chan CF, Chien TC, Cheng JK, Huang YY, Chiu CD, Lien CC. GABA is depolarizing in hippocampal dentate granule cells of the adolescent and adult rats. J Neurosci 2012 Jan 4;32: 62-67. *Co-First author (Corresponding author)
2010 Lin YC, Liu YC, Huang YY, Lien CC. High-density expression of Ca2+-permeable ASIC1a channels in NG2 glia of rat hippocampus. PLoS ONE 2010 Sep 10; 5 (9): e12665-e12672. (Corresponding author)
2010 Chu KC, Chiu CD, Hsu TT, Hsieh YM, Huang YY, Lien CC. Functional identification of an outwardly rectifying pH- and anesthetic-sensitive leak K+ conductance in hippocampal astrocytes. Eur J Neurosci 2010 Jul 28; 32: 725-35. (Corresponding author)
2010 Weng JY, Lin YC, Lien CC. Cell type-specific expression of acid-sensing ion channels in hippocampal interneurons. J Neurosci 2010 May 12; 30: 6548-58. (Corresponding author)
2010 Chiang PH, Yeh WC, Lee CT, Weng JY, Huang YY, Lien CC. M1-like muscarinic acetylcholine receptors regulate fast-spiking interneuron excitability in rat dentate gyrus. Neuroscience 2010 Aug 11; 169: 39-51. Epub 2010 Apr 28. (Corresponding author)
2009 Liao CW & Lien CC. Estimating intracellular Ca2+ concentrations and buffering in a dendritic inhibitory hippocampal interneuron. Neuroscience 2009 Dec 4; 164: 1701-11. (Corresponding author)
2006 Aponte Y, Lien CC, Jonas P. Hyperpolarization-activated cation channels in fast-spiking hippocampal interneurons. J Physiol (London) 2006 Jul 1; 574: 229-43.
2006 Lien CC, Mu Y, Vargas-Caballero M, Poo MM. Visual stimuli-induced LTD of GABAergic synapses mediated by presynaptic NMDA receptors. Nat Neurosci 2006 Mar; 9: 372-80.
2004 Oliver D*, Lien CC*, Soom M, Baukrowitz T, Jonas P, Fakler B. Functional conversion between A-type and delayed rectifier K+ channels by membrane lipids. Science (Research Article) 2004 Apr 9; 304: 265-70. (*equal contribution)
2003 Lien CC & Jonas P. Kv3 potassium conductance is necessary and kinetically optimized for high-frequency action potential generation in hippocampal interneurons. J Neurosci 2003 Mar 15; 23: 2058-68.
2002 Lien CC, Martina M, Schultz J, Ehmke H, Jonas P. Gating, modulation, and subunit composition of voltage-gated K+ channels in dendritic inhibitory interneurones of rat hippocampus. J Physiol (London) 2002 Jan 15; 538: 405-19.
年度 書名
2018 Martina M, Lien CC. (2018) Physiological Properties of Hippocampal Neurons. In: Cutsuridis V., Graham B., Cobb S., Vida I. (eds) Hippocampal Microcircuits. Springer Series in Computational Neuroscience. Springer, Cham.
獎項名稱 年度
科技部105年度傑出研究獎 2017
國家衛生研究院頒獎表揚執行整合性醫藥衛生科技計畫經 補助3次(含)以上 2016
德國學術交流總署 (DAAD) 海德堡大學訪問學者研獎 2012
德國洪堡基金會資深學者研究獎助
第11屆永信李天德醫藥科技獎－青年醫藥科技獎
柏林醫科大學神經治療(NeuroCure)訪問學者獎
陽明大學教師學術卓越獎勵 (2011-2012; 2013-2014;2015-2016; 2017-2019)
德國學術交流總署 (DAAD) 獎學金獲獎人(1998-2003)
陽明大學學生網路教學評估優良教師 (106年度第一學期，105年度第二學期，104年度第一學期，103年度第一學期，101年度第一學期，100年度第一學期，98年度第二學期，98年度第一學期，96年度第二學期)